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Gels
Special Issues
Hydrogel-Based Sensors for Biomedical Applications
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Hydrogel-Based Sensors for Biomedical Applications

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 3163

Special Issue Editor

Dr. Ruchi Gupta

E-Mail Website
Guest Editor
School of Chemistry, University of Birmingham, Birmingham B15 2TT, UK
Interests: optical sensors; microfluidics; smart hydrogels; sample preparation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the sensing mechanism and performance of hydrogel-based sensors along with their healthcare and biomedical applications.

There has been widespread interest in portable in vitro, wearable, and implantable sensors where the use of hydrogels is particularly attractive owing to their low toxicity, reduced biofouling, biocomptability, and ability to conform to body contours. Hydrogels have been utilised in these sensors in the form of stimuli-responsive materials or as scaffolds for hosting recognition elements such as antibodies, aptamers, and enzymes. Such hydrogel-based sensors rely on changes in refractive index, colour, geometry, and electrical conductance to measure a wide variety of analytes, including proteins, DNA, hormones, ions, and carbohydrates. Analytes have been measured in biological fluids, such as blood, saliva, tears, sweat, and urine, to enable disease diagnosis and prognosis for personalised medicine and closed-loop therapeutics.

We look forward to receiving your contributions to this Special Issue.

Dr. Ruchi Gupta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • sensors
  • point-of-care
  • wearable
  • implantable
  • biomedical
  • healthcare

Published Papers (1 paper)

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Research

13 pages, 2023 KiB  
Article
Stable DNA Aptamer–Metal–Organic Framework as Horseradish Peroxidase Mimic for Ultra-Sensitive Detection of Carcinoembryonic Antigen in Serum
by Lingjun Sha, Mingcong Zhu, Fuqing Lin, Xiaomeng Yu, Langjian Dong, Licheng Wu, Rong Ding, Shuai Wu and Jingjing Xu
Gels 2021, 7(4), 181; https://doi.org/10.3390/gels7040181 - 25 Oct 2021
Cited by 8 | Viewed by 2366
Abstract
Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. For CEA detection, a novel type of metal–organic framework (MOF) was prepared by grafting CEA aptamer-incorporated DNA tetrahedral (TDN) nanostructures into PCN-222 (Fe)-based MOF (referred as CEAapt-TDN-MOF colloid nanorods). The synthesized CEA [...] Read more.
Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. For CEA detection, a novel type of metal–organic framework (MOF) was prepared by grafting CEA aptamer-incorporated DNA tetrahedral (TDN) nanostructures into PCN-222 (Fe)-based MOF (referred as CEAapt-TDN-MOF colloid nanorods). The synthesized CEAapt-TDN-MOF is a very stable detection system due to the vertex phosphorylated TDN structure at the interface, possessing a one-year shelf-life. Moreover, it exhibits a significant horseradish peroxidase mimicking activity due to the iron porphyrin ring, which leads to a colorimetric reaction upon binding toward antibody-captured CEA. Using this method, we successfully achieved the highly specific and ultra-sensitive detection of CEA with a limit of detection as low as 3.3 pg/mL. In addition, this method can detect and analyze the target proteins in clinical serum samples, effectively identify the difference between normal individuals and patients with colon cancer, and provide a new method for the clinical diagnosis of tumors, demonstrating a great application potential. Full article
(This article belongs to the Special Issue Hydrogel-Based Sensors for Biomedical Applications)
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