Mobile Genetic Elements and Microbial Multidrug Resistance
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 2951
Special Issue Editors
Interests: clinical microbiology, antimicrobial resistance; bacterial fitness; virulence; foodborne pathogens; outbreaks; One Health; public health
Special Issues, Collections and Topics in MDPI journals
Interests: antimicrobial resistance; antibiotic resistance genes; bacterial fitness; bacterial adaptations; virulence; foodborne bacterial pathogens; infectious disease; One Health
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antimicrobial resistance (AMR) is one of the top ten public health challenges that face humanity. Microorganisms evolve to become resistant to the antimicrobials that have been used as primary interventions to control associated infectious diseases. The emergence and spread of AMR pose an unprecedented threat to human and veterinary medicine globally. AMR has been associated with high mortality and morbidity and devastating impacts on the economy. Resistance can develop via chromosomal mutations or the acquisition of disparate genetic elements that encode AMR. Resistance can then be transmitted vertically and/or via horizontal gene transfer, driving the evolution of resistant strains and populations. Subsequently, mobile genetic elements (MGEs) can play a paramount role in transmitting resistance genes throughout microbial populations, impacting different hosts and ecological niches, including humans, animals, food, and the environment.
Studies on MGEs are critical to delineate the factors and mechanisms that influence the increasing trends of resistance and provide a valuable resource to devise novel approaches for mitigating the threat of AMR and superbugs. This will also support stakeholders in improving the surveillance of AMR gene flow, identifying genetic reservoirs, and harnessing microbial ecology and evolutionary pathways to control drug-resistant microorganisms.
This Special Issue is focused on 1) addressing the global antimicrobial resistance threat, 2) filling knowledge gaps in the understanding of the transmission dynamics of AMR genes and MGEs, and 3) highlighting new advances and discoveries related to the emergence of problematic MDR organisms, especially those that exhibit resistance to critical and last resort antibiotics. We cordially invite researchers working in these areas to contribute Original Research, Case Reports, and General and Systematic Reviews.
Dr. Marwan Osman
Dr. Issmat Kassem
Guest Editors
Manuscript Submission Information
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Keywords
- antimicrobial resistance
- mobile genetic rlements
- plasmids
- transmission
- molecular epidemiology
- next generation sequencing
- genome analysis
- nucleotide polymorphism sequence
- microbial evolution
- microbial genetics
- evolutionary biology
- multidrug resistance
- outbreaks
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