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Cattle Molecular Immunology
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Cattle Molecular Immunology

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (25 March 2021) | Viewed by 4843

Special Issue Editor

Dr. Bianca Castiglioni

E-Mail Website
Guest Editor
Institute of Agricultural Biology and Biotechnology-Consiglio Nazionale delle Ricerche (IBBA-CNR), Via Einstein, 26900 Lodi, Italy
Interests: animal genomics and transcriptomics; microbiome; immune response; host–pathogen interaction in farm animals; mastitis

Special Issue Information

Dear Colleagues,

The United Nations predicts that the world population will reach 9.6 billion by 2050, with critical consequences for the sustainability of farming systems, for the safety of the food chain, and for human health. Like other agricultural sectors, cattle farming faces the challenge of having to produce more and better-quality food from the same resources (e.g., water, energy) to meet the growing global demand for animal products without increasing the environmental impact. In this context, improving cattle health remains an important issue for ensuring a sustainable livestock sector. To achieve this goal, research is needed to improve our understanding of the bovine immune response. The advent of high-throughput sequencing technologies has facilitated our knowledge of the immune response. As a result, important outcomes are being achieved in the field of -omics research on disease control and immune response in cattle. Therefore, given the recent progress in this area, we believe that this Special Issue will be useful in bringing together those molecular studies that increase our understanding of the immune response to disease in cattle.

We welcome the submission of original research papers and review articles related to advances in molecular studies for monitoring immune response and to better understand host–pathogen interaction in cattle. 

Dr. Bianca Castiglioni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bovine immune response
  • Immunogenetics
  • Host–pathogen interaction
  • Molecular bases of cattle diseases
  • Molecular pathology
  • Mastitis
  • Disease resistance
  • Gene expression
  • Transcriptomics
  • Genetics and genomics selection

Published Papers (2 papers)

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Research

10 pages, 1395 KiB  
Communication
Preliminary Evidence of Endotoxin Tolerance in Dairy Cows during the Transition Period
by Joel Filipe, Alessia Inglesi, Massimo Amadori, Flavia Guarneri, Laura Menchetti, Giulio Curone, Gabriele Brecchia, Daniele Vigo and Federica Riva
Genes 2021, 12(11), 1801; https://doi.org/10.3390/genes12111801 - 16 Nov 2021
Cited by 4 | Viewed by 1856
Abstract
The blastogenic response of bovine peripheral blood mononuclear cells (PBMCs) to lipopolysaccharides (LPS) has been investigated for a long time in our laboratories. In particular, a possible correlation between the blastogenic response to LPS and the disease resistance of dairy cows has been [...] Read more.
The blastogenic response of bovine peripheral blood mononuclear cells (PBMCs) to lipopolysaccharides (LPS) has been investigated for a long time in our laboratories. In particular, a possible correlation between the blastogenic response to LPS and the disease resistance of dairy cows has been suggested in previous studies. Isolated PBMCs from eight cows at three different time points during the transition period (T0 = 15 days before calving; T1 = 7 days post-calving; T2 = 21 days post-calving) were cultured in the presence or absence of LPS, and the blastogenic response was assayed 72 h after in vitro stimulation. Moreover, the gene expression of proinflammatory cytokines and kynurenine pathway molecules was investigated by real-time RT-PCR on both unstimulated and stimulated PBMCs. The cows were retrospectively divided into healthy and diseased, based on the development of peripartum diseases (subclinical ketosis and placenta retention). The comparison between healthy and diseased cows suggested that healthy animals seemed to better control the response to LPS. On the contrary, diseased animals showed a much higher inflammatory response to LPS. Moreover, cows were retrospectively classified as high and low responders based on the in vitro proliferative response of PBMCs to LPS, using the median value as a threshold. Unstimulated PBMCs of low responders showed higher expression of the proinflammatory cytokines Interleukin 1-β (IL-1β), Interleukin 6 (IL-6) and Tumor Necrosis Factor-α (TNF-α), compared to high responders. Our preliminary data suggest that, during the peripartum period, high responders seem to be more tolerant to endotoxins and develop a lower inflammatory response to different stressors. Instead, low responders could be more prone to the development of unwanted inflammatory conditions in response to mild/moderate stressors. Full article
(This article belongs to the Special Issue Cattle Molecular Immunology)
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13 pages, 2753 KiB  
Article
The Molecular Bases Study of the Inherited Diseases for the Health Maintenance of the Beef Cattle
by Elena Konovalova, Olga Romanenkova, Olga Kostyunina and Elena Gladyr
Genes 2021, 12(5), 678; https://doi.org/10.3390/genes12050678 - 30 Apr 2021
Cited by 3 | Viewed by 2469
Abstract
The article highlighted the problem of meat cattle genetic defects. The aim was the development of DNA tests for some genetic defects diagnostics, the determination of the animal carriers and their frequencies tracking in time. The 1490 DNA samples from the Aberdeen Angus [...] Read more.
The article highlighted the problem of meat cattle genetic defects. The aim was the development of DNA tests for some genetic defects diagnostics, the determination of the animal carriers and their frequencies tracking in time. The 1490 DNA samples from the Aberdeen Angus (n = 701), Hereford (n = 385), Simmental (n = 286) and Belgian Blue (n = 118) cattle have been genotyped on the genetic defects by newly created and earlier developed DNA tests based on AS-PCR and PCR-RFLP methods. The Aberdeen Angus cattle genotyping has revealed 2.38 ± 0.31% AMC-cows and 1.67 ± 0.19 % AMC-bulls, 0.65 ± 0.07% DDC-cows and 0.90 ± 0.10% DDC-bulls. The single animals among the Hereford cattle were carriers of MSUD and CWH (on 0.27 ± 0.05%), ICM and HY (on 0.16 ± 0.03%). The Simmental cattle were free from OS. All Belgian Blue livestock were M1- and 0.84%-CMD1-carriers. The different ages Aberdeen Angus cattle genotyping has shown the tendency of the AMC- and DDC frequencies to increase in the later generations. The statistically significant increase of DDC of 1.17% in the cows’ population born in 2019 compared to those born in 2015 allows concluding the further development of the DNA analysis-based measures preventing the manifestation of the genetic anomalies in meat cattle herds is necessary. Full article
(This article belongs to the Special Issue Cattle Molecular Immunology)
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