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Genes
Special Issues
Genetics, Genomics and Host Response of Chlamydiae
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Genetics, Genomics and Host Response of Chlamydiae

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".

Deadline for manuscript submissions: closed (30 April 2019) | Viewed by 3622

Special Issue Editors

Prof. Dr. Servaas A. Morré

E-Mail Website
Guest Editor
Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Institute GROW, Faculty of Health, Medicine & Life Sciences, University of Maastricht, 4-6, 6211 LK Maastricht, The Netherlands
Interests: epidemiology; diagnostics; immunogenetics; infectious diseases; valorization and translation; Chlamydia trachomatis
Special Issues, Collections and Topics in MDPI journals
Dr. Sander Ouburg

E-Mail Website
Guest Editor
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Microbiology & Infection Control, Laboratory of Immunogenetics, Amsterdam, The Netherlands
Interests: chlamydia trachomatis infections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue from Genes entitled "Genetics, Genomics, and Host Response of Chlamydiae" will focus on both bacterial and host-based genetics and genomics from a fundamental, translational, epidemiological, diagnostics, and policy perspective. It will take into account mRNA, protein, genetics including SNPs, genome analyses, serological, and other biomarkers on the basis of genetics and genomics in relation to Chlamydiae and Chlamydia-like infections in bacteria, animals, humans, and the environment. Submission is not only linked to people attending the 13th AACM, but those attending will receive special invites. Submissions will be closed 30th of April 2019, and until then all submitted manuscripts are welcome and will be published as soon as they are accepted. Please consider submitting your work to this Special Issue in Genes!

Prof. Servaas A. Morré
Dr. Sander Ouburg
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chlamydiae
  • Chlamydia-like
  • genetics
  • genomics
  • biomarkers
  • bacterial host

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Published Papers (1 paper)

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10 pages, 532 KiB  
Perspective
The Potential Role for Host Genetic Profiling in Screening for Chlamydia-Associated Tubal Factor Infertility (TFI)—New Perspectives
by Jelena Malogajski, Ivan Branković, Jolande A. Land, Pierre P. M. Thomas, Servaas A. Morré and Elena Ambrosino
Genes 2019, 10(6), 410; https://doi.org/10.3390/genes10060410 - 28 May 2019
Cited by 6 | Viewed by 3223
Abstract
Host immunogenetic factors can affect late complications of urogenital infections with Chlamydia trachomatis. These findings are creating new avenues for updating existing risk prediction models for C. trachomatis-associated tubal factor infertility (TFI). Research into host factors and its utilization may therefore [...] Read more.
Host immunogenetic factors can affect late complications of urogenital infections with Chlamydia trachomatis. These findings are creating new avenues for updating existing risk prediction models for C. trachomatis-associated tubal factor infertility (TFI). Research into host factors and its utilization may therefore have future implications for diagnosing C. trachomatis-induced infertility. We outline the epidemiological situation regarding C. trachomatis and TFI in high-income countries. Thereupon, we review the main characteristics of the population undergoing fertility work-up and identify screening and diagnostic strategies for TFI currently in place. The Netherlands is an exemplary model for the state of the art in high-income countries. Within the framework of existing clinical approaches, we propose a scenario for the translation of relevant genome-based information into triage of infertile women, with the objective of implementing genetic profiling in the routine investigation of TFI. Furthermore, we describe the state of the art in relevant gene- and single nucleotide polymorphism (SNP) based clinical prediction models and place our perspectives in the context of these applications. We conclude that the introduction of a genetic test of proven validity into the assessment of TFI should help reduce patient burden from invasive and costly examinations by achieving a more precise risk stratification. Full article
(This article belongs to the Special Issue Genetics, Genomics and Host Response of Chlamydiae)
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