The Emerging Roles of RNA in Cancer Progression
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 587
Special Issue Editor
Interests: genetic and epigenetic mechanisms contributing to metastasis and cancer therapy resistance; non-coding RNAs as regulators of cancer stemness, EMT and cancer therapy resistance; CRISPR/Cas9 genome editing system in cancer research and treatment; immune checkpoint proteins as new targets for anti-cancer therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The advent of high-throughput sequencing has led to an explosion of data revealing the diversity, processing and expression of RNA sequences. A fundamental surprise is that in addition to the role of RNA in protein coding, there are highly stable long non-coding RNAs (lncRNAs), not associated with protien coding sequences, that bind RNA binding proteins, microRNAs or other RNAs, many with documented biological functions of their own. More recently, in addition to lncRNAs, 3’UTR sequences, which also interact with RNA binding elements, show dynamic, non-random expression in the absence of their cognate coding sequences, resulting in isolated 3’UTR (i3’UTR) expression. These i3’UTRs provide a potenial additional, and not previously envisioned, mode of gene regulation; i3'UTRs appear poised to regulate cell-specific gene expression and state, have shown close but distinct expression to their cognate CDS and are likely to be critically important to the basic fundamentals of biological science. While particular roles for some i3’UTRs have been elucidated, as a community we are just begining to understand the full spectrum of their expression and have only scratched the surface as to the possible impact of their functionality.
In this Special Issue, we will focus on the bioinformatic or cell biological demonstration of the synthesis, localization or function of such i3’UTRS, with an emphasis on, but not restricted to, cells during development or cells in transitonal phases (such as during cancer progression). As much has been published on the role of alternative polyadenlyation of 3’UTR sequences, it will not be a focus here. This study of i3’UTRs (and in turn CDS expression in the absence of 3’UTRs) is a new area of experimental investigation, and these early studies will provide seminal support to this burgeoning field.
Dr. Peixin Dong
Guest Editor
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Keywords
- RNA
- neurons
- development
- transitional state
- cancer progression
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