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Genes
Special Issues
Targeting of Long Non-Coding RNAs in Cancer
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Targeting of Long Non-Coding RNAs in Cancer

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (30 April 2020)

Special Issue Editors

Dr. Peixin Dong

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Hokkaido University, Sapporo, Japan
Interests: genetic and epigenetic mechanisms contributing to metastasis and cancer therapy resistance; non-coding RNAs as regulators of cancer stemness, EMT and cancer therapy resistance; CRISPR/Cas9 genome editing system in cancer research and treatment; immune checkpoint proteins as new targets for anti-cancer therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Junming Yue

E-Mail Website
Guest Editor
1. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
2. Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Interests: RNA; tumour cells; ovarian cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues

The human transcriptome is composed of several types of non-coding RNAs, which are classified in different groups depending on their length. The major groups are the small ncRNAs (such as microRNAs) and the long ncRNAs (lncRNAs) directly involved in the regulation of many cellular processes.

LncRNAs play an important role in driving cancer initiation and development through their interactions with other cellular macromolecules (including DNA, protein, and RNA). LncRNAs exhibit cell- and/or tumor-specific expression, making lncRNAs emerge as attractive diagnostic biomarkers and therapeutic targets for cancers. However, the function of many lncRNAs are still to be found in various cancer types, to understand the mechanism by which lncRNAs modulate multiple biological pathways in cancer cells.

This Special Issue aims to present novel insights into the diverse functions of lncRNAs in various types of human tumors, the potential impacts of lncRNAs on cancer biology and their diagnostic and prognostic and therapeutic significance. Our objective is to gather a collection of reviews and original research articles that cover the advancements in the field of lncRNAs, focusing on the following topics:

i) Biological roles of lncRNAs in cancer initiation and progression

ii) Genetic and epigenetic mechanisms contributing to dysregulation of lncRNAs

iii) LncRNAs as regulators of cancer stem cells and epithelial to mesenchymal transition

iv) Novel anti-cancer therapies targeting lncRNAs

v) Targeting lncRNAs via CRISPR/Cas9 genome editing system in cancer research and treatment

 

Kind regards,

Prof. Peixin Dong
Prof. Junming Yue
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Non-coding RNAs
  • cancer metastasis
  • cancer stem cell
  • EMT and resistance to therapy

Published Papers (1 paper)

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Research

11 pages, 2511 KiB  
Article
Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma
by Edie-Rosmin Wu, Ying-Erh Chou, Yu-Fan Liu, Kuan-Chun Hsueh, Hsiang-Lin Lee, Shun-Fa Yang and Shih-Chi Su
Genes 2019, 10(7), 506; https://doi.org/10.3390/genes10070506 - 4 Jul 2019
Cited by 30 | Viewed by 2990
Abstract
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding RNA (lncRNA) H19 can have both [...] Read more.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding RNA (lncRNA) H19 can have both promotive and inhibitory effects on cancer development, revealing a dual role in tumorigenesis. In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC (OR, 1.291; 95% CI, 1.003–1.661; p = 0.047, and OR, 1.361; 95% CI, 1.054–1.758; p = 0.018, respectively), whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC (OR, 0.606; 95% CI, 0.410–0.895; p = 0.012). Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors (for stage III/IV; OR, 0.566; 95% CI, 0.342–0.937; p = 0.027). In addition, carriers of a particular haplotype of three H19 SNPs tested were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer. Full article
(This article belongs to the Special Issue Targeting of Long Non-Coding RNAs in Cancer)
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