Epigenetic Variation Influences on Livestock Production and Disease Traits

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 1860

Special Issue Editors


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Guest Editor
Department of Animal Veterinary and Food Sciences, College of Agriculture and Life Sciences, University of Idaho, Moscow, ID 83844-2330, USA
Interests: livestock; genomics; epigenetics; recombination; prion disease; cytogenetics

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Guest Editor
Department of Animal and Veterinary Sciences, University of Vermont, Burlington, VT 05405, USA
Interests: animal genomics; epigenetics; epigenomics; DNA methylation

Special Issue Information

Dear Colleagues,

Accumulating evidence shows that epigenetic marks (including DNA methylation, chromatin remodeling, histone modifications, and other molecules that can transmit epigenetic information) can influence livestock species in gene expression and phenotypic outcomes. The data currently available show that epigenetic factors play an important role in the expression of imprinting genes, cellular processes, fat metabolism, and the development of muscle tissue in livestock. Meanwhile, there is already compelling evidence that various additives in the diet have the ability to induce epigenetic modifications of phenotypic variability. There is growing pressure to increase livestock production in light of an expanding human population and environmental challenges, but the related epigenetic data on livestock to complement genomic information and support advances in improvement breeding and health management is limited. In this Special Issue, we will examine the recent discoveries on epigenetic processes due to DNA methylation, histone modification, and chromatin remodeling and their impacts on disease traits and production traits in livestock, and discuss the influence of epigenetic factors on livestock health and productivity, which would be very vital to improve livestock productivity.

Dr. Brenda Murdoch
Dr. Stephanie McKay
Guest Editors

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Keywords

  • epigenetics
  • methylation
  • histone modification
  • livestock

Published Papers (1 paper)

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Research

21 pages, 1290 KiB  
Article
Genome-Wide Analysis of lncRNA and mRNA Expression in the Uterus of Laying Hens during Aging
by Guang Li, Xinyue Yang, Junyou Li and Bingkun Zhang
Genes 2023, 14(3), 639; https://doi.org/10.3390/genes14030639 - 3 Mar 2023
Cited by 2 | Viewed by 1522
Abstract
Eggshell plays an essential role in preventing physical damage and microbial invasions. Therefore, the analysis of genetic regulatory mechanisms of eggshell quality deterioration during aging in laying hens is important for the biosecurity and economic performance of poultry egg production worldwide. This study [...] Read more.
Eggshell plays an essential role in preventing physical damage and microbial invasions. Therefore, the analysis of genetic regulatory mechanisms of eggshell quality deterioration during aging in laying hens is important for the biosecurity and economic performance of poultry egg production worldwide. This study aimed to compare the differences in the expression profiles of long non-coding RNAs (lncRNAs) and mRNAs between old and young laying hens by the method of high-throughput RNA sequencing to identify candidate genes associated with aging in the uterus of laying hens. Overall, we detected 176 and 383 differentially expressed (DE) lncRNAs and mRNAs, respectively. Moreover, functional annotation analysis based on the Gene Ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) databases revealed that DE-lncRNAs and DE-mRNAs were significantly enriched in “phosphate-containing compound metabolic process”, “mitochondrial proton-transporting ATP synthase complex”, “inorganic anion transport”, and other terms related to eggshell calcification and cuticularization. Through integrated analysis, we found that some important genes such as FGF14, COL25A1, GPX8, and GRXCR1 and their corresponding lncRNAs were expressed differentially between two groups, and the results of quantitative real-time polymerase chain reaction (qPCR) among these genes were also in excellent agreement with the sequencing data. In addition, our study found that TCONS_00181492, TCONS_03234147, and TCONS_03123639 in the uterus of laying hens caused deterioration of eggshell quality in the late laying period by up-regulating their corresponding target genes FGF14, COL25A1, and GRXCR1 as well as down-regulating the target gene GPX8 by TCONS_01464392. Our findings will provide a valuable reference for the development of breeding programs aimed at breeding excellent poultry with high eggshell quality or regulating dietary nutrient levels to improve eggshell quality. Full article
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