DNA Repair, Genomic Instability and Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 706
Special Issue Editor
Interests: DNA damage and repair; genomic instability; gene targeting; DNA structure; cancer therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The maintenance of genome integrity is essential for proper cellular function and organismal survival. To protect the genome from endogenous and exogenous sources of DNA damage, cells have evolved a variety of DNA repair mechanisms. Paradoxically, in some cases, DNA repair proteins can promote genetic instability via error-prone processing, thereby contributing to the etiology and progression of diseases such as cancer. A notable example includes the processing of alternative (i.e., non-B) DNA structures, which can form repetitive DNA sequences and are abundant across genomes. In this Special Issue, we will highlight both canonical and aberrant DNA repair mechanisms, providing insights into their roles in genome integrity.
Prof. Dr. Karen M. Vasquez
Guest Editor
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Keywords
- DNA structure
- DNA damage
- DNA repair
- genomic instability
- mutagenesis
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