Non-coding RNA Markers and Epigenetic Modifications in Tumor Identification
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "RNA".
Deadline for manuscript submissions: closed (25 April 2022) | Viewed by 2732
Special Issue Editor
Interests: gene regulation; epigenetics; non-coding RNAs; cancer; lung diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
During the last decade, the discovery of non-coding RNAs’ deregulation in different cancer cells has been the focus of attention for numerous investigations. The emergence of deep sequencing technologies has generated a high amount of public data available to further explore the role of ncRNAs, as well as epigenetic modifications (i.e., chromatin remodeling) in early diagnostics and stratification of patients. Therefore, there is a large amount of interest in the study of non-coding RNAs and epigenetic regulators to personalize clinical practice and be able to apply more specific and effective treatments to cancer patients.
For instance, miRNAs are negative modulators of gene expression since they bind to mRNAs of different genes. Thus, these ncRNAs are linked to gene regulatory networks. Moreover, miRNAs functionally cooperate with ncRNA molecules, such as circRNAs and lncRNAs, to control their cellular presence. The alterations of this equilibrium have a very important outcome that affects the cellular fate, since important imbalances can propitiate the development of diseases.
Their tissue-specific expression and stable structure make them ideal candidates that may allow identifying tumor subtypes in an accurate manner. Their potential as biomarkers, not only for diagnostic and prognostic purposes but also as therapeutic targets for this disease, makes them valuable molecules for research.
This Special Issue aims to shed some light on the use of novel candidates for tumor identification and strategies involving non-coding RNAs and epigenetic modifications, as well as describe new advances obtained in clinics. Original research manuscripts and comprehensive reviews are welcome to this call.Dr. Elena Lopez-Jimenez
Guest Editor
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Keywords
- miRNAs
- non-coding RNAs
- biomarkers
- gene regulation
- cancer
- therapeutic targets
- personalized medicine
