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Genes
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Non-Mendelian Inheritance
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Non-Mendelian Inheritance

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Population and Evolutionary Genetics and Genomics".

Deadline for manuscript submissions: closed (15 December 2020) | Viewed by 4367

Special Issue Editor

Dr. Marco Passamonti

E-Mail Website
Guest Editor
Department of Biological, Geological, and Environmental Sciences (BiGeA), University of Bologna, 40126 Bologna, Italy
Interests: mitochondral genetics and genomics; mitochondrial inheritance; doubly uniparental inheritance; genomic conflicts; sex determination; RNA Interference; phylogenetics; Bivalvia; molecular phylogenetics

Special Issue Information

Dear Colleagues,

Despite the fact that the foundations of modern genetics (as well as of modern Theory of Evolution itself) have Mendelian roots, many examples are nowadays known that do not adhere to the basic Mendelian paradigm, and the current view of inheritance has been largely widened. In fact, many genetic determinants do not follow strict Mendelian inheritance patterns, at diverse organization levels, from genes to chromosomes to organelles. Strict Mendelian inheritance is challenged by phenomena such as meiotic drive, sex-linked inheritance, and genomic imprinting. This Special Issue aims to review and assess new and relevant cases of nonMendelian inheritance patterns, as well as their effects on the biology and evolution of studied eukaryote model systems, as well as the utility of such experimental models for eukaryote research.

Prof. Marco Passamonti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-mendelian inheritance
  • organelle genetics and inheritance
  • genomic imprinting
  • meiotic drive
  • sex-linked inheritance
  • eukaryotes

Published Papers (1 paper)

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Research

11 pages, 937 KiB  
Article
Confirmation of Paternity despite Three Genetic Incompatibilities at Chromosome 2
by Andrzej Doniec, Wojciech Łuczak, Maria Wróbel, Miłosz Januła, Andrzej Ossowski, Paweł Grzmil and Tomasz Kupiec
Genes 2021, 12(1), 62; https://doi.org/10.3390/genes12010062 - 4 Jan 2021
Cited by 5 | Viewed by 2780
Abstract
DNA testing in cases of disputed paternity is a routine analysis carried out in genetic laboratories. The purpose of the test is to demonstrate similarities and differences in analyzed genetic markers between the alleged father, mother, and a child. The existence of differences [...] Read more.
DNA testing in cases of disputed paternity is a routine analysis carried out in genetic laboratories. The purpose of the test is to demonstrate similarities and differences in analyzed genetic markers between the alleged father, mother, and a child. The existence of differences in the examined loci between the child and the presumed father may indicate the exclusion of biological parenthood. However, another reason for such differences is genetic mutations, including chromosome aberrations and genome mutations. The presented results relate to genetic analyses carried out on three persons for the purposes of disputed paternity testing. A deviation from inheritance based on Mendel’s Law was found in 7 out of 53 STR-type loci examined. All polymorphic loci that ruled out the paternity of the alleged father were located on chromosome 2. Additional analysis of 32 insertion–deletion markers (DIPplex, Qiagen) and sequencing of 94 polymorphic positions of the single nucleotide polymorphism (SNP) type (Illumina, ForenSeq) did not exclude the defendant’s biological paternity. A sequence analysis of STR alleles and their flanking regions confirmed the hypothesis that the alleles on chromosome 2 of the child may originate only from the mother. The results of the tests did not allow exclusion of the paternity of the alleged father, but are an example of uniparental maternal disomy, which is briefly described in the literature. Full article
(This article belongs to the Special Issue Non-Mendelian Inheritance)
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