Caffeine in the Diet: Health Implications, Safety Issues, and Molecular Mechanisms

Dear Colleagues,

We are pleased to announce a Special Issue on the impact of caffeine from the diet on health, its physiological effects, and metabolic outcomes in the International Journal of Environmental Research and Public Health.

Caffeine is considered the most widely consumed psychoactive agent, since it is a valuable and craved component of coffee and tea. Caffeine has also gained a special place within cultural traditions and social life, mostly associated with work productivity and improved performance. However, the growing consumption of caffeine-containing products has raised concerns about its potential health implications among consumers. How dietary caffeine is metabolized and interacts with other bioactive compounds, its biochemical and molecular effects on different metabolic pathways, and definitively its role in the human organism have not been fully elucidated, and require more research. 

This Special Issue seeks to collect state-of-the-art original research with a focus on the implications of caffeine in the diet, including clinical, epidemiological, in vivo, and in vitro studies underlining the impact of caffeine in health and disease. Since the knowledge about caffeine is continuously progressing, this Special Issue will collect the most updated insights into the effects of dietary caffeine on health. We welcome your contributions in the form of original research articles, reviews, short-communications, systematic reviews, or meta-analyses covering topics such as:

• Trends in the consumption of caffeine;
• Toxicology and safety aspects of caffeine consumption;
• Beneficial and adverse effects of dietary caffeine;
• Caffeine as a nutraceutical for the prevention of disease;
• Molecular mechanisms of the action of caffeine;
• Analysis of caffeine in food and biological samples.

Dr. Miguel Rebollo-Hernanz
Prof. Dr. Yolanda Aguilera
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• caffeine
• diet
• toxicology
• phytochemicals
• functional foods
• nutraceuticals
• antioxidant
• bioavailability
• biotransformation
• inflammation
• metabolism
• noncommunicable diseases
• inflammation
• metabolism
• noncommunicable diseases