Noninvasive Imaging in Cardiology: From Diagnosis to Treatment

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Imaging".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 143

Special Issue Editor


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Guest Editor
Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore
Interests: multi-modality imaging
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Special Issue Information

Dear Colleagues,

Noninvasive imaging has become a cornerstone of contemporary cardiology, enabling accurate diagnosis, risk stratification, and treatment planning across a wide spectrum of cardiovascular diseases. Advances in modalities such as echocardiography, cardiac magnetic resonance (CMR), computed tomography (CT), and nuclear cardiology have transformed clinical practice by providing precise structural, functional, and molecular information without the need for invasive procedures. As cardiovascular disease remains the leading cause of morbidity and mortality worldwide, innovations in imaging hold the promise of improving patient outcomes through earlier detection, more refined phenotyping, and personalized therapy.

This Special Issue aims to showcase recent advances in noninvasive cardiovascular imaging, covering methodological developments, clinical applications, and translational research. The scope aligns with the journal’s mission to disseminate high-quality research that advances knowledge and practice in cardiovascular medicine. We invite contributions that highlight how noninvasive imaging informs diagnosis, guides therapy, and impacts prognosis in real-world settings. Our goal is to bring together original research and authoritative reviews that will be of interest to cardiologists, radiologists, imaging scientists, and allied healthcare professionals.

In this Special Issue, we welcome original research articles, state-of-the-art reviews, and perspectives. Potential topics include (but are not limited to) the following:

  • Advances in echocardiography, cardiac CT, CMR, and nuclear cardiology;
  • Novel imaging biomarkers for risk prediction and stratification;
  • Imaging-guided therapy and intervention planning;
  • Artificial intelligence and machine learning in cardiovascular imaging;
  • Comparative effectiveness of imaging modalities;
  • Cost-effectiveness, sustainability and health policy implications of noninvasive imaging;
  • Imaging in specific populations (e.g., older adults, women, patients with multimorbidity);
  • Emerging technologies and future directions in cardiovascular imaging.

I look forward to receiving your contributions.

Dr. Ching-Hui Sia
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac imaging
  • echocardiography
  • cardiac magnetic resonance
  • computed tomography
  • nuclear cardiology
  • artificial intelligence
  • risk stratification
  • diagnosis
  • therapy guidance
  • prognosis

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Published Papers (1 paper)

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Research

13 pages, 1654 KB  
Article
Prognostic Value of Cadmium-Zinc-Telluride Dedicated Cardiac SPECT Dynamic Myocardial Perfusion Quantitative Imaging in Patients with Coronary Chronic Total Occlusion: A Pilot Study
by Linlin Li, Zekun Pang, Jianming Li and Wengui Xu
J. Cardiovasc. Dev. Dis. 2026, 13(3), 118; https://doi.org/10.3390/jcdd13030118 - 4 Mar 2026
Abstract
Background: The prevalence of chronic total occlusion (CTO) lesions is as high as 30% in patients undergoing coronary angiography (CAG). Some CTO patients do not undergo revascularization due to procedural complexity and high risks. This study aimed to investigate the value of cadmium-zinc-telluride [...] Read more.
Background: The prevalence of chronic total occlusion (CTO) lesions is as high as 30% in patients undergoing coronary angiography (CAG). Some CTO patients do not undergo revascularization due to procedural complexity and high risks. This study aimed to investigate the value of cadmium-zinc-telluride (CZT) SPECT dynamic myocardial perfusion imaging (MPI) for risk stratification and prognosis assessment in patients with coronary CTO. Methods: This study retrospectively included 62 patients who underwent CZT SPECT dynamic MPI examination and were diagnosed with CTO by angiography. The primary endpoint was major adverse cardiovascular events (MACEs), defined as cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, hospitalization for heart failure, late coronary revascularization, or hospitalization for unstable angina. Results: Over a median follow-up of 17 months (IQR 11–23), 15 MACEs occurred. The stress myocardial blood flow (sMBF) and coronary flow reserve (CFR) in the CTO territory were significantly lower in the MACEs group compared to the non-MACEs group (all p < 0.05). Receiver operating characteristic analysis determined the optimal cut-off values for predicting MACEs as sMBF < 0.75 (sensitivity 78.7%, specificity 73.3%, AUC = 0.74, p < 0.05) and CFR < 1.39 (sensitivity 70.2%, specificity 80.0%, AUC = 0.75, p < 0.01). Kaplan–Meier survival analysis showed that patients with impaired sMBF (p < 0.001) or impaired CFR (p < 0.01), defined by these cut-off values, had significantly worse clinical outcomes. Conclusions: The results of this study indicate that sMBF and CFR obtained from CZT SPECT dynamic MPI provide valuable prognostic prediction for patients with coronary CTO lesions, offering critical evidence for identifying high-risk patients requiring active intervention. Full article
(This article belongs to the Special Issue Noninvasive Imaging in Cardiology: From Diagnosis to Treatment)
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