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Transcatheter and Surgical Approaches to Complications of Transcatheter Procedures: Current...
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Transcatheter and Surgical Approaches to Complications of Transcatheter Procedures: Current Trends and Future Challenges

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiac Surgery".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1046

Special Issue Editors

Dr. Antonio Nenna

E-Mail Website
Guest Editor
Unit of Cardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy
Interests: cardiac surgery; heart valve surgery; critical care
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giuseppe Patti

E-Mail Website
Guest Editor
Department of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy
Interests: cardiology; transcatheter procedures; TAVI
Dr. Giovanni Casali

E-Mail Website
Guest Editor
Unit of Cardiac Surgery, Ospedale Maggiore della Carità di Novara, Corso Mazzini 18, 28100 Novara, Italy
Interests: cardiac surgery; heart valve surgery; critical care

Special Issue Information

Dear Colleagues,

Over the last years, transcatheter procedures [such as transcatheter aortic valve implantation (TAVI), transcatheter mitral and tricuspid valve edge-to-edge repair (M-TEER and T-TEER), transcatheter mitral and tricuspid repair or replacement (TMVR and TTVR), transcatheter left atrial appendage occlusion (LAAO), transcatheter paravalvular leak (PVL) closure, and transcatheter closure of patent foramen ovale (PFO)] have become an important minimally invasive alternative to open-heart cardiac surgery for patients at high surgical risk and suffering from severe valve disease. Modern cardiac imaging, the computational tools for the 3D imaging analysis of cardiac and vascular structures, and the use of fusion technologies during procedures have become important key factors for the success of percutaneous procedures. Similarly, the evolution of devices has helped in improving the hemodynamic results, simplifying the procedural steps and lowering the rate of procedural unsuccess, vascular injury, paravalvular leak, and permanent pacemaker implantation.

However, adverse events still represent a daunting issue of transcatheter procedures, as both short term (e.g., valve mal-positioning) and long term (e.g., device endocarditis) complications damper the benefits of the procedure and might pose patients at extremely high risk for their urgent or emergent treatment. This Special Issue aims to summarize the latest advances in the treatment of transcatheter procedures related complications, focusing on both percutaneous and surgical approaches.

By reading this Special Issue, cardiologists and cardiac surgeons involved in modern heart teams should easily improve their knowledge by learning about the latest trends in transcatheter procedures as presented by experts in the field. Both original research contributions and state-of-the-art reviews are welcome.

Dr. Antonio Nenna
Prof. Dr. Giuseppe Patti
Dr. Giovanni Casali
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transcatheter
  • complications
  • cardiac surgery
  • heart valve surgery
  • complications
  • TAVR

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Published Papers (2 papers)

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Review

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20 pages, 1092 KiB  
Review
Paravalvular Leak in Transcatheter Aortic Valve Implantation: A Review of Current Challenges and Future Directions
by Andreas Synetos, Nikolaos Ktenopoulos, Odysseas Katsaros, Konstantina Vlasopoulou, Maria Drakopoulou, Leonidas Koliastasis, Ioannis Kachrimanidis, Anastasios Apostolos, Sotirios Tsalamandris, George Latsios, Konstantinos Toutouzas, Ioannis Patrikios and Constantinos Tsioufis
J. Cardiovasc. Dev. Dis. 2025, 12(4), 125; https://doi.org/10.3390/jcdd12040125 - 31 Mar 2025
Viewed by 297
Abstract
Transcatheter aortic valve implantation (TAVI) has emerged as a revolutionary therapeutic modality for the management of severe aortic stenosis (AS), particularly in patients who are at high or prohibitive risk for surgical aortic valve replacement (SAVR). Over the past decade, extensive clinical evidence [...] Read more.
Transcatheter aortic valve implantation (TAVI) has emerged as a revolutionary therapeutic modality for the management of severe aortic stenosis (AS), particularly in patients who are at high or prohibitive risk for surgical aortic valve replacement (SAVR). Over the past decade, extensive clinical evidence has expanded the indications for TAVI to include intermediate- and low-risk populations, which usually represent a population of younger age, in which the most common complications of TAVI, including paravalvular leak (PVL) and pacemaker implantation, should be avoided. This review focuses on the incidence and predictors of PVL in various types of TAVI implantation, its clinical implication, and the prevention strategies to tackle this complication. Full article
(This article belongs to the Special Issue Transcatheter and Surgical Approaches to Complications of Transcatheter Procedures: Current Trends and Future Challenges)
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9 pages, 455 KiB  
Protocol
Transfemoral Transcatheter Aortic Valve Implantation at Hospitals Without On-Site Cardiac Surgery (TAVI at Home): A Multicenter Prospective Interventional Study
by Miriam Compagnone, Gianni Dall’Ara, Simone Grotti, Greta Mambelli, Elisabetta Fabbri, Carlo Savini, Marco Balducelli, Andrea Santarelli, Elia Iorio, Beatriz Vaquerizo, Alfredo Marchese, Giuseppe Tarantini, Francesco Saia, Chiara Zingaretti, Carolina Moretti, Caterina Cavazza, Bernadette Vertogen, Filippo Ottani, Andrea Rubboli, Oriana Nanni, Carmine Pizzi, Marcello Galvani and Fabio Felice Tarantinoadd Show full author list remove Hide full author list
J. Cardiovasc. Dev. Dis. 2025, 12(2), 63; https://doi.org/10.3390/jcdd12020063 - 10 Feb 2025
Cited by 1 | Viewed by 606
Abstract
Transcatheter aortic valve implantation (TAVI) has become the standard of care for elderly patients with aortic stenosis. International guidelines recommend that TAVI should be performed only in centers with on-site cardiac surgery (CS). However, rapidly evolving TAVI technology and increasing operator expertise have [...] Read more.
Transcatheter aortic valve implantation (TAVI) has become the standard of care for elderly patients with aortic stenosis. International guidelines recommend that TAVI should be performed only in centers with on-site cardiac surgery (CS). However, rapidly evolving TAVI technology and increasing operator expertise have significantly reduced peri-procedural complications, including those requiring rescue surgery, which occur in less than 0.5% of cases. Furthermore, only a minority of major complications are treated with CS, and the outcomes remain unfavorable. TAVI in centers without CS could represent a solution to reduce waiting times and ensure continuity of care for fragile patients. “TAVI at Home” is a single-arm prospective interventional study. According to sample size calculations based on literature data, the study aims to enroll a total of 200 patients, beginning with a run-in phase of 20 patients to establish safety. The primary endpoint is 30-day all-cause mortality. Secondary endpoints include technical success and the evaluation of single complications 30 days after the procedure. Hospitals without CS that are eligible to perform TAVI must have a high volume of coronary percutaneous interventions, operators with established TAVI experience, collaboration with vascular surgeons, and regular Heart Team meetings to ensure rigorous patient selection. Full article
(This article belongs to the Special Issue Transcatheter and Surgical Approaches to Complications of Transcatheter Procedures: Current Trends and Future Challenges)
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