Functionalization of Scaffolds Qualified for Bone and Cartilage Regeneration
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".
Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 243
Special Issue Editor
Special Issue Information
Dear Colleagues,
Based on its regenerative microenvironment, bone, including its marrow, is the only tissue that possesses the ability to heal without any post-damage fibrous tissue (scarring). However, the occurrence of critical size defects following tumour resection, trauma or infection, as well as defects associated with avascular osteonecrosis or total revision arthroplasty surgery, represents an unsolved challenge for orthopaedic and trauma surgeons. Moreover, demographic changes caused by the increase in life expectancy in the modern world have created a demand for regenerative concepts with the rise of elderly populations. In this context, osteoporotic fractures and delayed bone healing represent not only major individual burdens but also economic burdens on the healthcare system. Although autologous bone grafting remains the gold standard for the treatment of local bone defects, it is affected by the relevant co-morbidities. Moreover, as the resources of autologous bone are limited, there is a pressing need for the provision of alternative treatments. Therefore, bone substitute materials are frequently applied in the field of orthopaedics. In contrast, the development of scaffolds, which enable cartilage regeneration, remains in its infancy. Many promising approaches have failed in their clinical applications, but new technologies offer hope for the future as methods that can be used to create safe joints and prevent total joint replacement. The physicochemical properties of the materials qualified for bone or cartilage regeneration play crucial roles in protein binding, cellular adherence and differentiation and, thus, local bone/cartilage healing. Consequently, these substances can contribute significantly to the maintenance and recovery of mobility and, therefore, the quality of life of the affected patients. This Special Issue explores aspects of the current research on bone and cartilage substitute materials. In light of the translational aspect of this research, the papers present both basic research data and clinical outcomes measures. This Special Issue places particular emphasis on the biofunctionalization of scaffolds by cytokines, growth factors and cells. It is our hope that the research papers contained within it will stimulate and motivate future research in this important field.
Prof. Dr. Marcus Jäger
Guest Editor
Manuscript Submission Information
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Keywords
- bone substitutes
- cartilage regeneration
- bone healing
- scaffolds
- mesenchymal cells
- tissue collectors
- growth factors
- cytokines
- collagens
- biofunctionalization
