Breakthroughs in Drug Discovery and Delivery in Oncology
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 587
Special Issue Editors
Interests: cancer therapy; signaling pathways; precision medicine; drug delivery system
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; drug design; ligand–protein binding; molecular interactions; molecular modeling; hit identification; lead optimization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the time of precision medicine, most of the efforts are dedicated to developing new drugs that target specific proteins to precisely kill cancer cells. As recognized by Robert A. Weinberg and Douglas Hanahan in the seminal paper “Hallmarks of Cancer: The Next Generation”, the tumor microenvironment is a key element in the tumorigenesis process. The identification of ligands able to modulate the activity of specific targets in cancer and supporting stroma cells is becoming one of the most studied research fields in drug discovery. In the oncology field, since many potential drug targets were identified and novel technologies were developed in the early drug discovery steps, the detection of target modulators has become a common goal for medicinal chemists and chemical biologists. In addition, bio- and nanomaterials are being applied to improve the pharmacokinetic parameters.
This Special Issue aims to provide a forum for the dissemination of:
a) The latest information on novel approaches for the identification and optimization of target modulators;
b) Research studies reporting the design, synthesis, and biological evaluation of potentially active ligands;
c) Strategies for drug nano-formulations and their therapeutic applications.
Dr. Flavio Rizzolio
Prof. Dr. Tiziano Tuccinardi
Guest Editors
Manuscript Submission Information
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Keywords
- Drug design
- Drug discovery
- Drug delivery
- Molecular modeling
- Nanostructured materials
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