Drugs Discovery Based on Natural Products
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 298
Special Issue Editors
Interests: biochemistry; molecular and cellular biology; lemon peel polyphenol extract; Annurca apple polyphenols; functional foods; colon cancer; matrix metalloproteinases (MMP)-2/9; Interleukin-6; cell invasiveness; natural anti-metastatic agent; proteomics; endoplasmic reticulum stress; cell imaging
Interests: preclinical and translational pharmacology; antioxidant effect of natural products; autophagy; neurodegeneration; neuroprotection effect of NPs; glaucoma; diabetic retinopathy
Interests: biochemistry; cell cultures; flow cytometry; immunocytochemistry; design, structural and biological characterization of peptide; Matrine quinolizidine alkaloid; cystic fibrosis; oils extracted; lemon-scented herbal plants; human B-lymphoma
Special Issue Information
Dear Colleagues,
Historically, the identification and study of natural products (NPs) derived from natural resources such as microbes and plants from the terrestrial and marine environments, has led to an important contribution to pharmacotherapy in many therapeutic areas, including infectious diseases (antibiotics and antiviral agents) or cardiovascular diseases (statins). Furthermore, in the modern era of drug discovery, NPs play a major role in cancer treatment by modulating the cancer microenvironment and different signaling pathways: cell death pathways (apoptosis and autophagy), cell growth, proliferation and differentiation pathways, remodeling of extracellular matrices pathways (metastasis formation) and inflammatory process. The rapid development of resistance to chemotherapeutic drugs and their undesirable side effects makes it necessary, today again, the discovery and development of novel drugs with greater therapeutic efficiency and with fewer side effects, not just for cancer therapy, but also for several other pathologies such as cystic fibrosis, neurodegenerative diseases, visual pathologies (diabetes-related retinopathy, glaucoma, age-related macular degeneration, etc.).
I invite researchers to contribute with original research articles as well as review articles, which will increase knowledge and new perspective about drug discovery based on NPs including, new strategy of isolation and characterization of new bioactive natural compounds, new biological targets, and pharmacological effects.
Dr. Valentina Pagliara
Dr. Annagrazia Adornetto
Dr. Anna Basile
Guest Editors
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Keywords
- natural products
- drug design and development
- polyphenols
- combination therapy
- proteomics
- metabolomics
- natural anti-metastatic agent
- signaling pathways
- global health
- neuroprotection
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