New Antibiotics from Natural Sources
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (1 July 2021) | Viewed by 475
Special Issue Editor
Interests: natural products chemistry; chemical biology; metabolomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Natural sources have proven to be attractive sources of antibiotics due to their structural diversity and interesting biological activity. The definition of “antibiotic” was originally “an antibiotic is a chemical substance produced by micro-organisms, which has the capacity to inhibit the growth of and even to destroy bacteria and other micro-organisms”. After that, microbial compounds with various biological actions were discovered; therefore, the definition has extended to microbial compounds not only with antimicrobial action but also with antifungal action, antineoplastic action, immunosuppressive action, and lipid-lowering action, etc. However, the prevalence of the discovery of new antibiotics with novel structures has been declining in recent years, and such antibiotics are urgently needed. Meanwhile, the 2015 Nobel Prize, awarded to scientists that contributed to the discovery of an anti-parasitic drug lead “avermectin”, reminded us of the significance of and necessity of tackling this field. Additionally, the recent discovery of new antibiotics such as “teixobactin” (Nature, 2015) and “corbomycin” (Nature, 2020) has led to re-recognition of their excellent sources in antibiotics screening.
As Guest Editor of this Special Issue, I encourage researchers and scientists involved in this field to submit papers on new findings that may offer significant advances in the area.
Dr. Nobuhiro KoyamaGuest Editor
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Keywords
- Antibiotics
- Anti-microbial compounds
- Anti-infectives
- Mechanism of action
- Target identification.
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