Microfluidic Technologies for Biological and Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 6675

Special Issue Editor


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Guest Editor
Institutes of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 35053, Taiwan
Interests: microfluidics; lab-on-a-chip; organ-on-a-chip; single cell analysis

Special Issue Information

Dear Colleagues,

In recent decades, the multidisciplinary microfluidics research community has contributed to and witnessed the evolution of microfluidic technologies, from novel research concepts to practical tools, which have convincingly reduced the gap between engineering, life science and medicine. Recently, lab-on-a-chip, point-of-care, miniaturized system, organ-on-a-chip, and micro-biosensors are frequently seen in the keywords of published papers in the biology and medicine fields, highlighting the increasing importance of microfluidics in bio applications. By providing unprecedented functionality, such as single cell manipulation, high sensitivity analysis, precise sample handling, etc., microfluidic technologies have played a pivotal role in advancing life sciences. Microfluidic technologies may also be used to solve global health problems and to develop precision medicine for future health care by reducing diagnostics and treatment costs.

The goal of this Special Issue is to collect the latest advances of microfluidic technologies for biological and biomedical applications. We welcome researchers to submit manuscripts concerning elements of microfluidics, including, but not limited to, microsensors, microactuators, microfabrication, microfluidics simulation, micorpumps, nanomaterials and biomaterials. We also welcome researchers to submit their works of novel microfluidic devices or miniaturized systems targeting bio-applications.

Dr. Chia-Hsien Hsu
Guest Editor

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Keywords

  • microfluidics
  • miniaturized system
  • lab-on-a-chip
  • point-of-care
  • organ-on-a-chip
  • microdevice

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Published Papers (1 paper)

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Review

33 pages, 3531 KiB  
Review
Microfluidics for Peptidomics, Proteomics, and Cell Analysis
by Rui Vitorino, Sofia Guedes, João Pinto da Costa and Václav Kašička
Nanomaterials 2021, 11(5), 1118; https://doi.org/10.3390/nano11051118 - 26 Apr 2021
Cited by 36 | Viewed by 6116
Abstract
Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control chemical, biological, and physical processes relevant [...] Read more.
Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control chemical, biological, and physical processes relevant to separation, analysis, and detection. Currently, microfluidic devices play an important role in many biological, chemical, physical, biotechnological and engineering applications. There are numerous ways to fabricate the necessary microchannels and integrate them into microfluidic platforms. In peptidomics and proteomics, microfluidics is often used in combination with mass spectrometric (MS) analysis. This review provides an overview of using microfluidic systems for peptidomics, proteomics and cell analysis. The application of microfluidics in combination with MS detection and other novel techniques to answer clinical questions is also discussed in the context of disease diagnosis and therapy. Recent developments and applications of capillary and microchip (electro)separation methods in proteomic and peptidomic analysis are summarized. The state of the art of microchip platforms for cell sorting and single-cell analysis is also discussed. Advances in detection methods are reported, and new applications in proteomics and peptidomics, quality control of peptide and protein pharmaceuticals, analysis of proteins and peptides in biomatrices and determination of their physicochemical parameters are highlighted. Full article
(This article belongs to the Special Issue Microfluidic Technologies for Biological and Biomedical Applications)
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