Nanostructured Metal Oxides for Cancer Detection and Therapy

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 2724

Special Issue Editor


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Guest Editor
Department of Physics and Earth Science, University of Ferrara, 44122 Ferrara, Italy
Interests: physics of matter; modeling of electronic transport; semiconductors; nanostructures; cancer detection

Special Issue Information

Dear Colleagues,

Despite the wide assortment of chemoresistive materials, metal oxides continue to maintain their leading role in gas-sensing, because of their high sensitivity, low cost, and easy implementation. Unfortunately, the system lacks intrinsic selectivity. Therefore, several studies aiming at creating selective sensor arrays have been carried out.

In recent years, a large part of the sensor community has concentrated its research efforts into two separate directions, which, in fact, can rarely be followed by a single research group.

The first line consists of basic understanding of the mechanisms of sensing, trying to develop models for the receptor and transducer functions of these devices. The second one explores the wide range of applications of this technology to people’s health care.

In particular, breath and skin analysis to detect cancer markers, e.g., volatile organic compounds, with metal-oxide-based devices are the most followed routes, specifically to detect melanomas, lung cancer, and derived metastases. Recently, also fecal, urine, blood, and ill-tissue analyses have attracted widespread interest. The aim of this Special Issue is to become a review of the state-of-the-art of applications of metal oxides to the problem of cancer detection. Thus, we will try to provide a broader view of the most promising results presented by the leading laboratories in the field.

Prof. Dr. Cesare Malagù
Guest Editor

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Published Papers (1 paper)

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Research

8 pages, 1324 KiB  
Article
Colorectal Cancer Study with Nanostructured Sensors: Tumor Marker Screening of Patient Biopsies
by Michele Astolfi, Giorgio Rispoli, Gabriele Anania, Veronica Nevoso, Elena Artioli, Nicolò Landini, Mascia Benedusi, Elisabetta Melloni, Paola Secchiero, Veronica Tisato, Giulia Zonta and Cesare Malagù
Nanomaterials 2020, 10(4), 606; https://doi.org/10.3390/nano10040606 - 26 Mar 2020
Cited by 11 | Viewed by 2220
Abstract
Despite the great progress in screening techniques and medical treatments, colorectal cancer remains one of the most widespread cancers in both sexes, with a high death rate. In this work, the volatile compounds released from human colon cancer tissues were detected by a [...] Read more.
Despite the great progress in screening techniques and medical treatments, colorectal cancer remains one of the most widespread cancers in both sexes, with a high death rate. In this work, the volatile compounds released from human colon cancer tissues were detected by a set of four different chemoresistive sensors, made with a nanostructured powder of metal-oxide materials, inserted into an innovative patented device. The sensor responses to the exhalation of a primary cancer sample and of a healthy sample (both of the same weight, collected during colorectal surgery from the intestine of the same patient) were statistically analyzed. The sensors gave reversible, reproducible, and fast responses for at least one year of continuous use, making them quite superior in respect to the existing diagnostic methods. Preliminary results obtained using principal component analysis of the sensor responses to samples removed from 13 patients indicate that the nanostructured sensors employed in this study were able to distinguish between healthy and tumor tissue samples with coherent responses (the discrimination power of the most sensitive sensor was about 17%), highlighting a strong potential for clinical practice. Full article
(This article belongs to the Special Issue Nanostructured Metal Oxides for Cancer Detection and Therapy)
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