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Nanomaterials
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Theranostic Nanomedicine and Nanomaterials
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Theranostic Nanomedicine and Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 11009

Special Issue Editor

Dr. Teodora Mocan

E-Mail Website
Guest Editor
Physiology Department, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania
Interests: nanomedicine; nanotoxicology; nanomediated immunoprophylaxis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomedicine, describing the numerous applications of nanomaterials towards high-standard diagnosis, treatment, and prophylaxis of disease, has been capturing increased attention during late years. The unique physicochemical properties of nano-objects starting with size, surface charge, variability in shape, numerous binding opportunities create unlimited opportunities for human health applications.

Among all imagined applications, the aspect of simultaneous functional binding opens great avenues for synchronicity of diagnosis and treatment of human disease, enriching the reported results of theranostic domain. Evidences and concepts this Special Issue welcomes are focused on, but not limited to imagistic diagnosis, sensors, photo thermal anticancer therapies, drug targeting, antimicrobial and regenerative therapies. We welcome trans- and interdisciplinary approaches, offering significant new views on the complexity of the domain and mechanisms involved.

Dr. Teodora Mocan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • theranostic applications
  • nanomedicine
  • nanomaterials
  • anticancer
  • antimicrobial
  • pro-regenerative

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Published Papers (3 papers)

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Research

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11 pages, 577 KiB  
Article
Analytical Performance and Validation of a Reliable Method Based on Graphite Furnace Atomic Absorption Spectrometry for the Determination of Gold Nanoparticles in Biological Tissues
by Oana Cadar, Teodora Mocan, Cecilia Roman and Marin Senila
Nanomaterials 2021, 11(12), 3370; https://doi.org/10.3390/nano11123370 - 12 Dec 2021
Cited by 6 | Viewed by 2728
Abstract
Gold nanoparticles (AuNPs) have a wide-ranging application and are widespread in samples with complex matrices; thus, efficient analytical procedures are necessary to identify and characterize this analyte. A sensitive analytical method for determination of AuNPs content in biological tissues, based on microwave-assisted acid [...] Read more.
Gold nanoparticles (AuNPs) have a wide-ranging application and are widespread in samples with complex matrices; thus, efficient analytical procedures are necessary to identify and characterize this analyte. A sensitive analytical method for determination of AuNPs content in biological tissues, based on microwave-assisted acid wet digestion and graphite furnace atomic absorption spectrometry (GFAAS) validated in accordance with the requirements of Eurachem guideline and ISO 17025 standard, is presented in this study. The digestion procedure was optimized, and the figures of merit such as selectivity, limit of detection (0.43 µg L−1), limit of quantification (1.29 µg L−1, corresponding to 12.9 µg kg−1 in tissue sample, considering the digestion), working range, linearity, repeatability ((RSDr 4.15%), intermediate precision (RSDR 8.07%), recovery in accuracy study (97%), were methodically evaluated. The measurement uncertainty was assessed considering the main sources of uncertainties and the calculated relative expanded uncertainty (k = 2) was 12.5%. The method was applied for the determination of AuNPs in six biological tissues (liver, small intestine, heart, lungs, brain and kidneys) and the found concentrations were generally at low levels, close or lower than LOQ. Full article
(This article belongs to the Special Issue Theranostic Nanomedicine and Nanomaterials)
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25 pages, 6765 KiB  
Article
Modelling in Synthesis and Optimization of Active Vaccinal Components
by Oana-Constantina Margin, Eva-Henrietta Dulf, Teodora Mocan and Lucian Mocan
Nanomaterials 2021, 11(11), 3001; https://doi.org/10.3390/nano11113001 - 8 Nov 2021
Cited by 1 | Viewed by 1730
Abstract
Cancer is the second leading cause of mortality worldwide, behind heart diseases, accounting for 10 million deaths each year. This study focusses on adenocarcinoma, which is a target of a number of anticancer therapies presently being tested in medical and pharmaceutical studies. The [...] Read more.
Cancer is the second leading cause of mortality worldwide, behind heart diseases, accounting for 10 million deaths each year. This study focusses on adenocarcinoma, which is a target of a number of anticancer therapies presently being tested in medical and pharmaceutical studies. The innovative study for a therapeutic vaccine comprises the investigation of gold nanoparticles and their influence on the immune response for the annihilation of cancer cells. The model is intended to be realized using Quantitative-Structure Activity Relationship (QSAR) methods, explicitly artificial neural networks combined with fuzzy rules, to enhance automated properties of neural nets with human perception characteristics. Image processing techniques such as morphological transformations and watershed segmentation are used to extract and calculate certain molecular characteristics from hyperspectral images. The quantification of single-cell properties is one of the key resolutions, representing the treatment efficiency in therapy of colon and rectum cancerous conditions. This was accomplished by using manually counted cells as a reference point for comparing segmentation results. The early findings acquired are conclusive for further study; thus, the extracted features will be used in the feature optimization process first, followed by neural network building of the required model. Full article
(This article belongs to the Special Issue Theranostic Nanomedicine and Nanomaterials)
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Review

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17 pages, 1262 KiB  
Review
Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications
by Robert Szabo, Constantin Bodolea and Teodora Mocan
Nanomaterials 2021, 11(11), 2958; https://doi.org/10.3390/nano11112958 - 4 Nov 2021
Cited by 23 | Viewed by 5950
Abstract
Understanding of how the human organism functions has preoccupied researchers in medicine for a very long time. While most of the mechanisms are well understood and detailed thoroughly, medicine has yet much to discover. Iron (Fe), Copper (Cu), and Zinc (Zn) are elements [...] Read more.
Understanding of how the human organism functions has preoccupied researchers in medicine for a very long time. While most of the mechanisms are well understood and detailed thoroughly, medicine has yet much to discover. Iron (Fe), Copper (Cu), and Zinc (Zn) are elements on which organisms, ranging from simple bacteria all the way to complex ones such as mammals, rely on these divalent ions. Compounded by the continuously evolving biotechnologies, these ions are still relevant today. This review article aims at recapping the mechanisms involved in Fe, Cu, and Zn homeostasis. By applying the knowledge and expanding on future research areas, this article aims to shine new light of existing illness. Thanks to the expanding field of nanotechnology, genetic disorders such as hemochromatosis and thalassemia can be managed today. Nanoparticles (NPs) improve delivery of ions and confer targeting capabilities, with the potential for use in treatment and diagnosis. Iron deficiency, cancer, and sepsis are persisting major issues. While targeted delivery using Fe NPs can be used as food fortifiers, chemotherapeutic agents against cancer cells and microbes have been developed using both Fe and Cu NPs. A fast and accurate means of diagnosis is a major impacting factor on outcome of patients, especially when critically ill. Good quality imaging and bed side diagnostic tools are possible using NPs, which may positively impact outcome. Full article
(This article belongs to the Special Issue Theranostic Nanomedicine and Nanomaterials)
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