Micro/Nanobubbles for Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1537

Special Issue Editor


E-Mail Website
Guest Editor
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China
Interests: fabrication of novel micro/nanobubbles; micro/nanobubbles for multimodality biomedical imaging; ultrasound-imaging-guided drug delivery and therapy; micro/nanobubble-assisted bioeffect; smart acoustic drug delivery systems; micro/nanobubbles for theranostics

Special Issue Information

Dear Colleagues,

Gas-filled micro/nanobubbles encapsulated with a polymer, a lipid, surfactant shells, or various nanoparticles have been well established and applied in the biomedical field over the last decade. Micro/nanobubbles are distinctly distinguished from other carrier materials because of their high compressibility and nonlinear properties under ultrasound exposure. Since they have a strong acoustic impedance, they are able to reflect sound waves far more efficiently than the surrounding fluid and biological tissue. Therefore, the use of bubbles in ultrasound imaging can effectively enhance the reflection of ultrasound to obtain a higher image resolution. Additionally, different types of materials can be chosen to endow bubbles with different functions, such as specific targeting and being carriers for drugs, genes, and other contrast agents for multimodal imaging. Furthermore, the multiple bioeffects induced by oscillating micro/nanobubbles under ultrasound attention has led researchers to consider them as stimuli-responsive drug delivery systems, which could be widely applied in drug delivery, gene therapy, and regenerative medicine.

This Special Issue aims to cover the current state-of-the-art research on micro/nanobubbles and their biomedical applications beyond imaging and drug/gene delivery for anticancer treatment, antibacterial activity, and biosensing. The format of welcomed articles includes regular research papers, communications, and reviews. Potential topics include, but are not limited to:

  • Formation, stability, and structure of micro/nanobubbles;
  • Detection, imaging, and tracking methods for micro/nanobubbles;
  • Imaging and biosensing applications;
  • Drug and gene delivery applications;
  • Modeling of micro/nanobubbles.

Prof. Dr. Fang Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro/nanobubble preparation and modeling
  • multifunctional micro/nanobubbles
  • smart micro/nanobubbles
  • contrast agents
  • biomedical imaging
  • molecularly targeted imaging
  • micro/nanobubble-assisted drug delivery
  • tissue repair and regeneration
  • gene delivery
  • tumor imaging and therapy
  • cardiovascular disease imaging and therapy

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

12 pages, 3655 KiB  
Article
The Effect of Nanobubble Water Containing Cordyceps Extract and Withaferin A on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells
by Hanlin Han, Yixin Sun, Weixu Zhang, Zhenya Zhang and Tian Yuan
Nanomaterials 2023, 13(15), 2265; https://doi.org/10.3390/nano13152265 - 7 Aug 2023
Viewed by 1216
Abstract
Cordyceps extract and withaferin A (Wi-A) are natural compounds that have therapeutic effects on non-alcoholic fatty liver disease (NAFLD). However, their efficacy is limited and a long treatment duration is usually required. To enhance their efficiency, the synergistic effects of nanobubble water (NBW) [...] Read more.
Cordyceps extract and withaferin A (Wi-A) are natural compounds that have therapeutic effects on non-alcoholic fatty liver disease (NAFLD). However, their efficacy is limited and a long treatment duration is usually required. To enhance their efficiency, the synergistic effects of nanobubble water (NBW) derived from nitrogen, hydrogen, and oxygen gases were investigated. Results showed that the physical properties of all three NBWs, including nanobubble density (108 particles/mL) and zeta potential (below −22 mV), were stable during 48 h of storage. Hydrogen and nitrogen NBWs did not reduce, but instead promoted, free fatty acid-induced lipid accumulation in HepG2 cells. In contrast, oxygen NBW synergistically enhanced the effects of cordyceps extract and Wi-A. The lipid content decreased by 29% and 33% in the oxygen NBW + cordyceps extract and oxygen NBW + Wi-A groups, respectively, compared to reductions of 22% and 16% by aqueous extracts without NB. This study found that NBW may enhance the lipid-reducing effects of natural compounds, such as cordyceps extract and withaferin A, in hepatic cells. Further studies in animal experiments are needed to determine whether NBW has a potential application in NAFLD. Full article
(This article belongs to the Special Issue Micro/Nanobubbles for Biomedical Applications)
Show Figures

Figure 1

Back to TopTop