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Nanomaterials
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Biological Effects of Nanoparticles
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Biological Effects of Nanoparticles

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2636

Special Issue Editor

Dr. Wei Fan

E-Mail Website
Guest Editor
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, China
Interests: nanomaterials; biomedicine; tissue engineering; dentistry

Special Issue Information

Dear Colleagues,

Nanomaterials and related technology have become one of the most important research areas in recent decades and will be more important in the future as they are expected to lead to revolutionary change in science, technology, and our world in general. Especially in the biology and medicine areas, nanomaterials have provided new methods, prospects, and possibilities to solve difficult issues, such as tracking cancer cells, assisting in diagnosis and treatment of diseases, and inducing cell differentiation. Therefore, the biological effects of nanomaterials needs to be closely investigated to support their safer and more appropriate applications.

This Special Issue aims to compile a set of papers on the biological effects of nanomaterials and share up-to-date and state-of-the-art research in this interesting and important field.

Research articles, reviews, meta-analyses, and short communications on experiments and theories of biological effects of nanomaterials are welcome in this Special Issue.

All researchers in the field are cordially encouraged to submit their manuscripts for consideration for publication in this Special Issue.

Dr. Wei Fan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biology
  • medicine
  • application
  • effect

Published Papers (2 papers)

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Research

10 pages, 2118 KiB  
Article
Antibacterial Properties In Vitro of Magnesium Oxide Nanoparticles for Dental Applications
by Adriana-Patricia Rodríguez-Hernández, Alejandro L. Vega-Jiménez, América R. Vázquez-Olmos, Miriam Ortega-Maldonado and Laurie-Ann Ximenez-Fyvie
Nanomaterials 2023, 13(3), 502; https://doi.org/10.3390/nano13030502 - 27 Jan 2023
Cited by 11 | Viewed by 2277
Abstract
(1) Dental caries, periodontitis, or peri-implantitis are commensal infections related to oral biofilm former bacteria. Likewise, magnesium oxide nanoparticles (MgO-NPs) were studied to introduce them to the antibacterial properties of a few microorganisms. Considering this, the purpose of the present investigation was to [...] Read more.
(1) Dental caries, periodontitis, or peri-implantitis are commensal infections related to oral biofilm former bacteria. Likewise, magnesium oxide nanoparticles (MgO-NPs) were studied to introduce them to the antibacterial properties of a few microorganisms. Considering this, the purpose of the present investigation was to determine the antibacterial properties of MgO-NPs on representative oral strains. (2) Methods: MgO-NPs with a cubic crystal structure were obtained by magnesium hydroxide mechanical activation. After synthesis, the MgO-NPs product was annealed at 800 °C (2 h). The MgO-NPs obtained were tested against ten oral ATCC strains at ten serial concentrations (1:1 20.0–0.039 mg/mL per triplicate) using the micro-broth dilution method to determine the minimal inhibitory concentration (MIC) or minimal bactericidal concentration (MIB). Measures of OD595 were compared against each positive control with a Student’s t-test. Viability was corroborated by colony-forming units. (3) Results: The polycrystalline structure had an average size of 21 nm as determined by X-ray diffraction and transmission electron microscopy (high resolution). Antimicrobial sensitivity was observed in Capnocytophaga gingivalis (MIB/MIC 10–5 mg/mL), Eikenella corrodens (MIB 10 mg/mL), and Streptococcus sanguinis (MIB 20 mg/mL) at high concentrations of the MgO-NPs and at lower concentrations of the MgO-NPs in Actinomyces israelii (MIB 0.039 mg/mL), Fusobacterium nucleatum subsp. nucleatum (MIB/MIC 5–2.5 mg/mL), Porphyromonas gingivalis (MIB 20 mg/mL/MIC 2.5 mg/mL), Prevotella intermedia (MIB 0.625 mg/mL), Staphylococcus aureus (MIC 2.5 mg/mL), Streptococcus mutans (MIB 20 mg/mL/MIC 0.321 mg/mL), and Streptococcus sobrinus (MIB/MIC 5–2.5 mg/mL). (4) Conclusions: The MgO-NPs’ reported antibacterial properties in all oral biofilm strains were evaluated for potential use in dental applications. Full article
(This article belongs to the Special Issue Biological Effects of Nanoparticles)
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21 pages, 5706 KiB  
Article
Bacterial Magnetosomes Release Iron Ions and Induce Regulation of Iron Homeostasis in Endothelial Cells
by Wenjia Lai, Dan Li, Qingsong Wang, Yan Ma, Jiesheng Tian and Qiaojun Fang
Nanomaterials 2022, 12(22), 3995; https://doi.org/10.3390/nano12223995 - 13 Nov 2022
Cited by 3 | Viewed by 1521
Abstract
Magnetosomes (MAGs) extracted from magnetotactic bacteria are well-defined membrane-enveloped single-domain magnetic nanoparticles. Due to their superior magnetic and structural properties, MAGs constitute potential materials that can be manipulated via genetic and chemical engineering for use in biomedical and biotechnological applications. However, the long-term [...] Read more.
Magnetosomes (MAGs) extracted from magnetotactic bacteria are well-defined membrane-enveloped single-domain magnetic nanoparticles. Due to their superior magnetic and structural properties, MAGs constitute potential materials that can be manipulated via genetic and chemical engineering for use in biomedical and biotechnological applications. However, the long-term effects exerted by MAGs on cells are of concern in the context of in vivo applications. Meanwhile, it remains relatively unclear which mechanisms are employed by cells to process and degrade MAGs. Hence, a better understanding of MAGs’ degradation and fundamental signal modulations occurring throughout this process is essential. In the current study, we investigated the potential actions of MAGs on endothelial cells over a 10-day period. MAGs were retained in cells and found to gradually gather in the lysosome-like vesicles. Meanwhile, iron-ion release was observed. Proteomics further revealed a potential cellular mechanism underlying MAGs degradation, in which a group of proteins associated with vesicle biogenesis, and lysosomal enzymes, which participate in protein hydrolysis and lipid degradation, were rapidly upregulated. Moreover, the released iron triggered the regulation of the iron metabolic profiles. However, given that the levels of cell oxidative damage were relatively stable, the released iron ions were handled by iron metabolic profiles and incorporated into normal metabolic routes. These results provide insights into the cell response to MAGs degradation that may improve their in vivo applications. Full article
(This article belongs to the Special Issue Biological Effects of Nanoparticles)
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