Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.5
4.4
Journals
Nanomaterials
Special Issues
Magnetic Nanoparticle-Based Hyperthermia and Theranostics
share announcement

Magnetic Nanoparticle-Based Hyperthermia and Theranostics

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (12 August 2021) | Viewed by 21603

Special Issue Editors

Prof. Dr. Ren-Jei Chung

E-Mail Website
Guest Editor
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
Interests: biomaterials; electrochemical biosensors; nanobiotechnology; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Hsi-Chin Wu

E-Mail Website
Co-Guest Editor
Department of Mechanical and Materials Engineering, Tatung University, Taipei, Taiwan
Interests: biomaterials; nanomedicine; calcium phosphate
Special Issues, Collections and Topics in MDPI journals
Dr. Udesh Dhawan

E-Mail
Co-Guest Editor
Centre for the Cellular Microenvironment (CeMi), Biomedical Engineering Research Division, James Watt School of Engineering, Rankine Building, University of Glasgow, Scotland, UK
Interests: biomaterials; nano-biotechnology

Special Issue Information

Dear Colleagues,

Nanotechnological advancements in the last decade have revolutionized the fields of therapeutics, and nanoparticle-related applications are at its forefront. The discovery of experimental methodologies to fabricate nanoparticles showing high biocompatibility in vivo has encouraged biomedical engineers to test their applications in multiple domains. Magnetic nanoparticles (MNPs), essentially the ones displaying superparamagnetic properties, such as zero coercivity, display hyperthermia upon alternating magnetic field (AMF) stimulation. The ease of surface functionalization of MNPs allows their conjugation with anticancer drugs to achieve hyperthermia-induced chemodrug dissociation, resulting in controlled drug release. This behavior can be widely exploited by biomedical engineers in cancer theranostics considering the property of enhanced chemodrug sensitivity by the cancer stroma. Another advantageous feature of MNPs is their ability to affect T1 or T2 relaxation rates, thus enabling their applications as contrast agents in magnetic resonance imaging. Thus, multi-functional MNPs are attractive candidates for simultaneous tumor imaging and therapy, and thus, theranostics.

A plethora of research has therefore been conducted to conceptualize the design of MNPs for biological applications. While some studies have focused on the amalgamation of different metals to yield multimodal alloy nanoparticles, others have aimed to develop core–shell MNPs with extraordinary biocompatibility or to elucidate the mechanisms governing the MNPs’ mode-of-action. The latest trend involves the fabrication of biomolecule-tagged MNPs for cancer-cell-specific ingestion, thereby limiting harm to the healthy stroma. Thus, MNP-induced hyperthermia is a new rising field of interest.

This Special Issue invites research articles involving the design, fabrication, and utilization of magnetic nanoparticle-induced hyperthermia for biomedical applications. Review articles summarizing the existing literature on the advent of MNPs for hyperthermia-mediated applications are also welcome.

Prof. Dr. Ren-Jei Chung
Prof. Dr. His-Chin Wu
Dr. Udesh Dhawan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • hyperthermia
  • nanoparticles
  • cancer therapy
  • biomedical engineering
  • nanotechnology
  • theranostics

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 2664 KiB  
Article
Oral Cancer Theranostic Application of FeAu Bimetallic Nanoparticles Conjugated with MMP-1 Antibody
by Meng-Tsan Tsai, Ying-Sui Sun, Murugan Keerthi, Asit Kumar Panda, Udesh Dhawan, Yung-Hsiang Chang, Chih-Fang Lai, Michael Hsiao, Huey-Yuan Wang and Ren-Jei Chung
Nanomaterials 2022, 12(1), 61; https://doi.org/10.3390/nano12010061 - 27 Dec 2021
Cited by 9 | Viewed by 3013
Abstract
Metastatic oral squamous cell carcinoma (SCC) displays a poor disease prognosis with a 5-year survival rate of 39%. Chemotherapy has emerged as the mainstream treatment against small clusters of cancer cells but poses more risks than benefits for metastatic cells due to the [...] Read more.
Metastatic oral squamous cell carcinoma (SCC) displays a poor disease prognosis with a 5-year survival rate of 39%. Chemotherapy has emerged as the mainstream treatment against small clusters of cancer cells but poses more risks than benefits for metastatic cells due to the non-specificity and cytotoxicity. To overcome these obstacles, we conjugated antibodies specific for matrix metalloproteinase-1 (MMP-1), a prognostic biomarker of SCC, to iron–gold bimetallic nanoparticles (FeAu NPs) and explored the capability of this complex to target and limit SSC cell growth via magnetic field-induced hyperthermia. Our results showed that 4.32 ± 0.79 nm sized FeAu NPs were superparamagnetic in nature with a saturation magnetization (Ms) of 5.8 emu/g and elevated the media temperature to 45 °C, confirming the prospect to deliver hyperthermia. Furthermore, conjugation with MMP-1 antibodies resulted in a 3.07-fold higher uptake in HSC-3 (human tongue squamous cell carcinoma) cells as compared to L929 (fibroblast) cells, which translated to a 5-fold decrease in cell viability, confirming SCC targeting. Finally, upon magnetic stimulation, MMP-1-FeAu NPs conjugate triggered 89% HSC-3 cellular death, confirming the efficacy of antibody-conjugated nanoparticles in limiting SCC growth. The synergistic effect of biomarker-specific antibodies and magnetic nanoparticle-induced hyperthermia may open new doors towards SCC targeting for improved disease prognosis. Full article
(This article belongs to the Special Issue Magnetic Nanoparticle-Based Hyperthermia and Theranostics)
►▼ Show Figures

Graphical abstract

19 pages, 3388 KiB  
Article
Assessing Suitability of Co@Au Core/Shell Nanoparticle Geometry for Improved Theranostics in Colon Carcinoma
by Udesh Dhawan, Ching-Li Tseng, Huey-Yuan Wang, Shin-Yun Hsu, Meng-Tsan Tsai and Ren-Jei Chung
Nanomaterials 2021, 11(8), 2048; https://doi.org/10.3390/nano11082048 - 11 Aug 2021
Cited by 8 | Viewed by 2231
Abstract
The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size. However, little is known about the effect of nanomaterial geometry on cell behavior. To elucidate this and [...] Read more.
The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size. However, little is known about the effect of nanomaterial geometry on cell behavior. To elucidate this and to extend the application in cancer theranostics, we have engineered core–shell cobalt–gold nanoparticles with spherical (Co@Au NPs) and elliptical morphology (Co@Au NEs). Our results show that owing to superparamagnetism, Co@Au NPs can generate hyperthermia upon magnetic field stimulation. In contrast, due to the geometric difference, Co@Au NEs can be optically excited to generate hyperthermia upon photostimulation and elevate the medium temperature to 45 °C. Both nanomaterial geometries can be employed as prospective contrast agents; however, at identical concentration, Co@Au NPs exhibited 4-fold higher cytotoxicity to L929 fibroblasts as compared to Co@Au NEs, confirming the effect of nanomaterial geometry on cell fate. Furthermore, photostimulation-generated hyperthermia prompted detachment of anti-cancer drug, Methotrexate (MTX), from Co@Au NEs-MTX complex and which triggered 90% decrease in SW620 colon carcinoma cell viability, confirming their application in cancer theranostics. The geometry-based perturbation of cell fate can have a profound impact on our understanding of interactions at nano-bio interface which can be exploited for engineering materials with optimized geometries for superior theranostic applications. Full article
(This article belongs to the Special Issue Magnetic Nanoparticle-Based Hyperthermia and Theranostics)
►▼ Show Figures

Figure 1

18 pages, 4625 KiB  
Article
Capturing Amyloid-β Oligomers by Stirring with Microscaled Iron Oxide Stir Bars into Magnetic Plaques to Reduce Cytotoxicity toward Neuronal Cells
by Yuan-Chung Tsai, Jing-Chian Luo, Te-I Liu, I-Lin Lu, Ming-Yin Shen, Chun-Yu Chuang, Chorng-Shyan Chern and Hsin-Cheng Chiu
Nanomaterials 2020, 10(7), 1284; https://doi.org/10.3390/nano10071284 - 30 Jun 2020
Cited by 1 | Viewed by 2366
Abstract
Soluble amyloid-β oligomers (oAβ42)-induced neuronal death and inflammation response has been recognized as one of the major causes of Alzheimer’s disease (AD). In this work, a novel strategy adopting silica-coated iron oxide stir bar (MSB)-based AD therapy system via magnetic stirring-induced [...] Read more.
Soluble amyloid-β oligomers (oAβ42)-induced neuronal death and inflammation response has been recognized as one of the major causes of Alzheimer’s disease (AD). In this work, a novel strategy adopting silica-coated iron oxide stir bar (MSB)-based AD therapy system via magnetic stirring-induced capture of oAβ42 into magnetic plaques (mpAβ42) and activation of microglia on cellular plaque clearance was developed. With oAβ42 being effectively converted into mpAβ42, the neurotoxicity toward neuronal cells was thus greatly reduced. In addition to the good preservation of neurite outgrowth through the diminished uptake of oAβ42, neurons treated with oAβ42 under magnetic stirring also exhibited comparable neuron-specific protein expression to those in the absence of oAβ42. The phagocytic uptake of mpAβ42 by microglia was enhanced significantly as compared to the counterpart of oAβ42, and the M1 polarization of microglia often occurring after the uptake of oAβ42 restricted to an appreciable extent. As a result, the inflammation induced by pro-inflammatory cytokines was greatly alleviated. Full article
(This article belongs to the Special Issue Magnetic Nanoparticle-Based Hyperthermia and Theranostics)
►▼ Show Figures

Graphical abstract

16 pages, 13098 KiB  
Article
Engineering Core-Shell Structures of Magnetic Ferrite Nanoparticles for High Hyperthermia Performance
by Mohamed S. A. Darwish, Hohyeon Kim, Hwangjae Lee, Chiseon Ryu, Jae Young Lee and Jungwon Yoon
Nanomaterials 2020, 10(5), 991; https://doi.org/10.3390/nano10050991 - 21 May 2020
Cited by 34 | Viewed by 4231
Abstract
Magnetic ferrite nanoparticles (MFNs) with high heating efficiency are highly desirable for hyperthermia applications. As conventional MFNs usually show low heating efficiency with a lower specific loss power (SLP), extensive efforts to enhance the SLP of MFNs have been made by [...] Read more.
Magnetic ferrite nanoparticles (MFNs) with high heating efficiency are highly desirable for hyperthermia applications. As conventional MFNs usually show low heating efficiency with a lower specific loss power (SLP), extensive efforts to enhance the SLP of MFNs have been made by varying the particle compositions, sizes, and structures. In this study, we attempted to increase the SLP values by creating core-shell structures of MFNs. Accordingly, first we synthesized three different types of core ferrite nanoparticle of magnetite (mag), cobalt ferrite (cf) and zinc cobalt ferrite (zcf). Secondly, we synthesized eight bi-magnetic core-shell structured MFNs; Fe3O4@CoFe2O4 (mag@cf1, mag@cf2), CoFe2O4@Fe3O4 (cf@mag1, cf@mag2), Fe3O4@ZnCoFe2O4 (mag@zcf1, mag@zcf2), and ZnCoFe2O4@Fe3O4 (zcf@mag1, zcf@mag2), using a modified controlled co-precipitation process. SLP values of the prepared core-shell MFNs were investigated with respect to their compositions and core/shell dimensions while varying the applied magnetic field strength. Hyperthermia properties of the prepared core-shell MFNs were further compared to commercial magnetic nanoparticles under the safe limits of magnetic field parameters (<5 × 109 A/(m·s)). As a result, the highest SLP value (379.2 W/gmetal) was obtained for mag@zcf1, with a magnetic field strength of 50 kA/m and frequency of 97 kHz. On the other hand, the lowest SLP value (1.7 W/gmetal) was obtained for cf@mag1, with a magnetic field strength of 40 kA/m and frequency of 97 kHz. We also found that magnetic properties and thickness of the shell play critical roles in heating efficiency and hyperthermia performance. In conclusion, we successfully enhanced the SLP of MFNs by engineering their compositions and dimensions. Full article
(This article belongs to the Special Issue Magnetic Nanoparticle-Based Hyperthermia and Theranostics)
►▼ Show Figures

Figure 1

12 pages, 3913 KiB  
Article
Magnetic Graphene-Based Sheets for Bacteria Capture and Destruction Using a High-Frequency Magnetic Field
by Andri Hardiansyah, Ming-Chien Yang, Hung-Liang Liao, Yu-Wei Cheng, Fredina Destyorini, Yuyun Irmawati, Chi-Ming Liu, Ming-Chi Yung, Chuan-Chih Hsu and Ting-Yu Liu
Nanomaterials 2020, 10(4), 674; https://doi.org/10.3390/nano10040674 - 3 Apr 2020
Cited by 13 | Viewed by 3153
Abstract
Magnetic reduced graphene oxide (MRGO) sheets were prepared by embedding Fe3O4 nanoparticles on polyvinylpyrrolidone (PVP) and poly(diallyldimethylammonium chloride) (PDDA)-modified graphene oxide (GO) sheets for bacteria capture and destruction under a high-frequency magnetic field (HFMF). The characteristics of MRGO sheets were [...] Read more.
Magnetic reduced graphene oxide (MRGO) sheets were prepared by embedding Fe3O4 nanoparticles on polyvinylpyrrolidone (PVP) and poly(diallyldimethylammonium chloride) (PDDA)-modified graphene oxide (GO) sheets for bacteria capture and destruction under a high-frequency magnetic field (HFMF). The characteristics of MRGO sheets were evaluated systematically by transmission electron microscopy (TEM), scanning electron microscopy (SEM), zeta potential measurement, X-ray diffraction (XRD), vibrating sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS). TEM observation revealed that magnetic nanoparticles (8–10 nm) were dispersed on MRGO sheets. VSM measurements confirmed the superparamagnetic characteristics of the MRGO sheets. Under HFMF exposure, the temperature of MRGO sheets increased from 25 to 42 °C. Furthermore, we investigated the capability of MRGO sheets to capture and destroy bacteria (Staphylococcus aureus). The results show that MRGO sheets could capture bacteria and kill them through an HFMF, showing a great potential in magnetic separation and antibacterial application. Full article
(This article belongs to the Special Issue Magnetic Nanoparticle-Based Hyperthermia and Theranostics)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

21 pages, 5964 KiB  
Review
Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection
by Yanyue Wu, Zhiguo Lu, Yan Li, Jun Yang and Xin Zhang
Nanomaterials 2020, 10(8), 1441; https://doi.org/10.3390/nano10081441 - 24 Jul 2020
Cited by 38 | Viewed by 5703
Abstract
Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings [...] Read more.
Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches. Full article
(This article belongs to the Special Issue Magnetic Nanoparticle-Based Hyperthermia and Theranostics)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop