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Nanomaterials
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Recent Advances of Nanomedicines and Drugs
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Recent Advances of Nanomedicines and Drugs

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 July 2022) | Viewed by 3509

Special Issue Editor

Prof. Dr. Peiwei Gong

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China
Interests: nanomaterials; drug delivery; lubrication; nanomedicine; synergistic therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, with the increasing maturation of nanotechnology, nano-drug delivery systems and nanomedicine have been widely used for disease therapy due to their good biocompatibility, selectivity and drug delivery efficiency. Effectively taking advantage of the outstanding properties of nanomaterials can greatly promote the development of both nanomedicine and vaccines, and finally give more opportunities for patients to treat their diseases.

The present Special Issue of Nanomaterials is aimed at presenting the current state of the art in the use of nanomaterials in nanomedicine and vaccines. In the present Special Issue, we have invited contributions from leading groups in the field with the aim of giving a balanced view of the current state of the art in this discipline.

Prof. Dr. Peiwei Gong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanomedicine
  • drug delivery
  • vaccines
  • targeted therapy

Published Papers (2 papers)

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16 pages, 4156 KiB  
Article
p-Sulfonato-Calix[4]arene Micelles Stabilize a Povidone Iodine Solution: Supramolecular Interactions, Iodine Retention, and Bactericidal Activity
by Rossella Migliore, Loredana Ferreri, Danilo Aleo, Claudia Giovanna Leotta, Giovanni Mario Pitari, Nicola D’Antona, Carmelo Sgarlata and Grazia Maria Letizia Consoli
Nanomaterials 2023, 13(2), 286; https://doi.org/10.3390/nano13020286 - 10 Jan 2023
Cited by 2 | Viewed by 1789
Abstract
Povidone iodine (PVPI) is an antiseptic widely used against a broad spectrum of pathogens. However, undesired side-effects are still associated with PVPI treatment due to the irritant effect of iodine. Reducing the concentration of a PVPI formulation could provide safer and more friendly [...] Read more.
Povidone iodine (PVPI) is an antiseptic widely used against a broad spectrum of pathogens. However, undesired side-effects are still associated with PVPI treatment due to the irritant effect of iodine. Reducing the concentration of a PVPI formulation could provide safer and more friendly formulations, for routine use and applications in very delicate organs such as the eye. However, managing the storage of a low-concentration solution of PVPI is challenging due to the high iodine volatility. In this study, we demonstrated that an amphiphilic p-sulfonato-calix[4]arene derivative forming micelles (SC4OC6) improves the stability of a 0.1% PVPI aqueous buffered solution. UV-vis and NMR spectra as well as dynamic and electrophoretic light scattering measurements showed that SC4OC6 establishes non-covalent supramolecular interactions with PVPI, resulting in the formation of nanoaggregates with a negatively charged surface. Isothermal titration calorimetry provided the aggregation parameters and evidenced that the formation of the supramolecular assembly is an enthalpically favored process. The interaction of SC4OC6 with PVPI enhances the iodine retention and stability of the solution without affecting the rapid and effective bactericidal activity of PVPI, as demonstrated by a time-killing assay with Staphylococcus epidermidis. Full article
(This article belongs to the Special Issue Recent Advances of Nanomedicines and Drugs)
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21 pages, 7570 KiB  
Article
Biomineralized Manganese Oxide Nanoparticles Synergistically Relieve Tumor Hypoxia and Activate Immune Response with Radiotherapy in Non-Small Cell Lung Cancer
by Xinyu Liu, Meron Tsegay Kifle, Hongxin Xie, Liexi Xu, Maoling Luo, Yangyi Li, Zhengrong Huang, Yan Gong, Yuzhou Wu and Conghua Xie
Nanomaterials 2022, 12(18), 3138; https://doi.org/10.3390/nano12183138 - 10 Sep 2022
Cited by 14 | Viewed by 2742
Abstract
Radiotherapy (RT) is currently considered as an essential treatment for non-small cell lung cancer (NSCLC); it can induce cell death directly and indirectly via promoting systemic immune responses. However, there still exist obstacles that affect the efficacy of RT such as tumor hypoxia [...] Read more.
Radiotherapy (RT) is currently considered as an essential treatment for non-small cell lung cancer (NSCLC); it can induce cell death directly and indirectly via promoting systemic immune responses. However, there still exist obstacles that affect the efficacy of RT such as tumor hypoxia and immunosuppressive tumor microenvironment (TME). Herein, we report that the biomineralized manganese oxide nanoparticles (Bio-MnO2 NPs) prepared by mild enzymatic reaction could be a promising candidate to synergistically enhance RT and RT-induced immune responses by relieving tumor hypoxia and activating cGAS-STING pathway. Bio-MnO2 NPs could convert endogenic H2O2 to O2 and catalyze the generation of reactive oxygen species so as to sensitize the radiosensitivity of NSCLC cells. Meanwhile, the release of Mn2+ into the TME significantly enhanced the cGAS-STING activity to activate radio-immune responses, boosting immunogenic cell death and increasing cytotoxic T cell infiltration. Collectively, this work presents the great promise of TME reversal with Bio-MnO2 NPs to collaborate RT-induced antitumor immune responses in NSCLC. Full article
(This article belongs to the Special Issue Recent Advances of Nanomedicines and Drugs)
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