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Nanomaterials
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Nanocellulose for Drug Delivery: From Design to Application
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Nanocellulose for Drug Delivery: From Design to Application

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 9615

Special Issue Editors

Dr. Dana Kralisch

E-Mail Website
Guest Editor
JeNaCell GmbH, Göschwitzer Str. 22, D-07745 Jena, Germany
Prof. Dr. Dagmar Fischer

E-Mail Website
Guest Editor
Friedrich Schiller Universität Jena, Lessingstrasse 8, D-07743 Jena, Germany
Interests: nanobased drug delivery systems using natural and synthetic polymers; drug targeting; aspects of nanosafety including the development of alternative test systems according to the 3R concept; quality-by-design strategies for nanomaterials

Special Issue Information

Dear Colleagues,

Bacterial nanocellulose (BNC, also called bacterial cellulose or microbial cellulose) is a fascinating, naturally derived hydropolymer with many potential fields of innovative application. Among them, drug carrier systems are one of the most promising, since the unique combination properties of BNC (e.g., biocompatibility, no allergenic potential, purity, high surface/volume ratio, 3D network structure, high liquid uptake and retention capacity in combination with its mechanical stability) allows for the design of controlled drug delivery systems (DDS) well suited for oral as well as dermal applications. BNC itself is generated by several strains of acetic acid bacteria and can be produced today under industrial conditions. The material consists of pure cellulose fibers, which are connected in a three-dimensional nanostructured fiber network if cultivated under static conditions. Functionalizing, compositing, loading, pressing, drying, and coating those fibers are some of many methods applied to develop tailor-made DDS based on the native material. Although numerous scientific studies have already been published on this topic, there are still many questions left to be answered, information to be discovered, and ideas to be transferred from the laboratory into advanced products. We invite you to take part on this journey!

This Special Issue of Nanomaterials, “Nanocellulose for Drug Delivery: From Design to Application”, aims at collecting a compilation of articles that addresses both the open challenges and latest achievements in the development of BNC-based DDS. Investigations covering all stages of the development process, ranging from fundamental understanding of drug and matrix interactions and release mechanisms to the transfer of most promising developments into product development and (pre-)clinical studies are kindly invited in order to showcase the current momentum. We are looking forward to receiving your valuable contribution in the form of reviews, communications, and academic articles!


Dr. Dana Kralisch
Prof. Dr. Dagmar Fischer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial nanocellulose
  • bacterial cellulose
  • drug delivery system
  • characterization
  • functionalization
  • drug formulation
  • release profile
  • transdermal
  • oral
  • dosage form
  • in vitro and in vivo testing

Published Papers (3 papers)

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Research

16 pages, 5919 KiB  
Article
Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing
by Jessica Hoff, Berit Karl, Jana Gerstmeier, Uwe Beekmann, Lisa Schmölz, Friedemann Börner, Dana Kralisch, Michael Bauer, Oliver Werz, Dagmar Fischer, Stefan Lorkowski and Adrian T. Press
Nanomaterials 2021, 11(8), 1939; https://doi.org/10.3390/nano11081939 - 28 Jul 2021
Cited by 13 | Viewed by 2586
Abstract
Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological [...] Read more.
Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological conditions. The long-chain metabolites of vitamin E (LCM) are bioactive molecules that mediate cellular effects via oxidative stress signaling as well as anti-inflammatory pathways. However, the effect of LCM on wound healing has not been investigated. We administered the α-tocopherol-derived LCMs α-13′-hydroxychromanol (α-13′-OH) and α-13′-carboxychromanol (α-13′-COOH) as well as the natural product garcinoic acid, a δ-tocotrienol derivative, in different pharmaceutical formulations directly to wounds using a splinted wound mouse model to investigate their effects on the wounds’ proinflammatory microenvironment and wound healing. Garcinoic acid and, in particular, α-13′-COOH accelerated wound healing and quality of the newly formed tissue. We next loaded bacterial nanocellulose (BNC), a valuable nanomaterial used as a wound dressing with high potential for drug delivery, with α-13′-COOH. The controlled release of α-13′-COOH using BNC promoted wound healing and wound closure, mainly when a diabetic condition was induced before the injury. This study highlights the potential of α-13′-COOH combined with BNC as a potential active wound dressing for the advanced therapy of skin injuries. Full article
(This article belongs to the Special Issue Nanocellulose for Drug Delivery: From Design to Application)
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11 pages, 4298 KiB  
Article
A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
by Zhuo Chen, Zhinan Fu, Li Li, Enguang Ma and Xuhong Guo
Nanomaterials 2021, 11(3), 734; https://doi.org/10.3390/nano11030734 - 15 Mar 2021
Cited by 8 | Viewed by 2600
Abstract
Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic [...] Read more.
Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up. Full article
(This article belongs to the Special Issue Nanocellulose for Drug Delivery: From Design to Application)
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20 pages, 6935 KiB  
Article
Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds
by Uwe Beekmann, Paul Zahel, Berit Karl, Lisa Schmölz, Friedemann Börner, Jana Gerstmeier, Oliver Werz, Stefan Lorkowski, Cornelia Wiegand, Dagmar Fischer and Dana Kralisch
Nanomaterials 2020, 10(12), 2508; https://doi.org/10.3390/nano10122508 - 14 Dec 2020
Cited by 17 | Viewed by 3742
Abstract
Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study presents experimental [...] Read more.
Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study presents experimental outcomes for a natural anti-inflammatory product concept of boswellic acids from frankincense formulated in BC. Using esterification respectively (resp.) oxidation and subsequent coupling with phenylalanine and tryptophan, post-modification of BC was tested to facilitate lipophilic active pharmaceutical ingredient (API) incorporation. Diclofenac sodium and indomethacin were used as anti-inflammatory model drugs before the findings were transferred to boswellic acids. By acetylation of BC fibers, the loading efficiency for the more lipophilic API indomethacin and the release was increased by up to 65.6% and 25%, respectively, while no significant differences in loading could be found for the API diclofenac sodium. Post-modifications could be made while preserving biocompatibility, essential wound dressing properties and anti-inflammatory efficacy. Eventually, in vitro wound closure experiments and evaluations of the effect of secondary dressings completed the study. Full article
(This article belongs to the Special Issue Nanocellulose for Drug Delivery: From Design to Application)
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