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Nanomaterials
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Smart Nanomaterials in Tissue Engineering: Preparation, Applications, Challenges and Prospects
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Smart Nanomaterials in Tissue Engineering: Preparation, Applications, Challenges and Prospects

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 15332

Special Issue Editor

Dr. Eva Filova

E-Mail Website
Guest Editor
Department of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic
Interests: tissue engineering; regenerative medicine; nanofibres; composite scaffolds; drug delivery systems

Special Issue Information

Dear Colleagues,

Nanomaterials are fast developing materials that are used in many kinds of applications. Their nanosized structure has unique properties and their dimensions are similar to those of extracellular matrix components. The high surface-to-volume ratio allows high interaction between surrounding tissues and nanomaterials. Nanomaterials for tissue engineering have to be biocompatible, nonimmunogenic, and should support cell growth and differentiation into the desired cell types. This Special Issue will be focused on the development of novel nanomaterials for tissue engineering, different processes of their preparation, modifications, functionalization, cell-surface interactions, in vitro testing using different cell types or in vivo testing of biocompatibility and regeneration of different tissues, and future perspectives. The authors are kindly invited to contribute original research articles or review articles that cover the progressive methodologies and attitudes in the field of tissue engineering. The articles will be peer-reviewed and may be rejected.

Article formats include full articles, reviews and short communications.

Suggested topics include nanomaterials for tissue engineering

  • Novel methods of nanomaterials preparation
  • Functionalization of nanomaterials
  • Surface properties
  • Biomechanical properties
  • Drug delivery systems
  • Cell-surface interactions
  • In vitro or in vivo testing
  • New challenges for nanomaterials development

Dr. Eva Filova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tissue engineering
  • Nanomaterials
  • Cell-nanomaterial interactions
  • Tissue regeneration

Published Papers (4 papers)

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Research

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13 pages, 8731 KiB  
Article
Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications
by Xin Chen, Honghai Li, Weipeng Lu and Yanchuan Guo
Nanomaterials 2021, 11(5), 1316; https://doi.org/10.3390/nano11051316 - 17 May 2021
Cited by 34 | Viewed by 3353
Abstract
The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled [...] Read more.
The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). Besides this, the in vitro drug release profile was investigated; it showed that the release rate of the prepared coaxial porous nanofibers with two different pore sizes was 30.10 ± 3.51% and 35.04 ± 1.98% in the first 30 min, and became 92.66 ± 3.13% and 88.94 ± 1.58% after 14 days. Compared with the coaxial nonporous nanofibers and nanofibers prepared by uniaxial electrospinning with or without pores, the prepared coaxial porous nanofibers revealed that the burst release was mitigated and the dissolution rate of the hydrophobic drugs was increased. The further antimicrobial activity demonstrated that the inhibition zone diameter of the coaxial nanofibers with two different pore sizes was 1.70 ± 0.10 cm and 1.73 ± 0.23 cm, exhibiting a good antibacterial effect against Staphylococcus aureus. Therefore, the prepared nanofibers with the coaxial porous structures could serve as promising drug delivery systems. Full article
(This article belongs to the Special Issue Smart Nanomaterials in Tissue Engineering: Preparation, Applications, Challenges and Prospects)
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20 pages, 5389 KiB  
Article
The Effect of the Controlled Release of Platelet Lysate from PVA Nanomats on Keratinocytes, Endothelial Cells and Fibroblasts
by Elena Filova, Andreu Blanquer, Jarmila Knitlova, Martin Plencner, Vera Jencova, Barbora Koprivova, Maxim Lisnenko, Eva Kuzelova Kostakova, Renata Prochazkova and Lucie Bacakova
Nanomaterials 2021, 11(4), 995; https://doi.org/10.3390/nano11040995 - 13 Apr 2021
Cited by 6 | Viewed by 2270
Abstract
Platelet lysate (PL) provides a natural source of growth factors and other bioactive molecules, and the local controlled release of these bioactive PL components is capable of improving the healing of chronic wounds. Therefore, we prepared composite nanofibrous meshes via the needleless electrospinning [...] Read more.
Platelet lysate (PL) provides a natural source of growth factors and other bioactive molecules, and the local controlled release of these bioactive PL components is capable of improving the healing of chronic wounds. Therefore, we prepared composite nanofibrous meshes via the needleless electrospinning technique using poly(vinyl alcohol) (PVA) with a high molecular weight and with a high degree of hydrolysis with the incorporated PL (10% w/w). The morphology, wettability and protein release from the nanofibers was then assessed from the resulting composite PVA–PL nanomats. The bioactivity of the PVA–PL nanomats was proved in vitro using HaCaT keratinocytes, human saphenous endothelial cells (HSVECs) and 3T3 fibroblasts. The PVA–PL supported cell adhesion, proliferation, and viability. The improved phenotypic maturation of the HaCaT cells due to the PVA–PL was manifested via the formation of intermediate filaments positive for cytokeratin 10. The PVA–PL enhanced both the synthesis of the von Willebrand factor via HSVECs and HSVECs chemotaxis through membranes with 8 µm-sized pores. These results indicated the favorable effects of the PVA–PL nanomats on the three cell types involved in the wound healing process, and established PVA–PL nanomats as a promising candidate for further evaluation with respect to in vivo experiments. Full article
(This article belongs to the Special Issue Smart Nanomaterials in Tissue Engineering: Preparation, Applications, Challenges and Prospects)
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19 pages, 3442 KiB  
Article
A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules, to Improve Melanocyte Stimulation in Vitiligo Treatment
by Karolina Vocetkova, Vera Sovkova, Matej Buzgo, Vera Lukasova, Radek Divin, Michala Rampichova, Pavel Blazek, Tomas Zikmund, Jozef Kaiser, Zdenek Karpisek, Evzen Amler and Eva Filova
Nanomaterials 2020, 10(9), 1801; https://doi.org/10.3390/nano10091801 - 10 Sep 2020
Cited by 9 | Viewed by 3331
Abstract
Vitiligo is the most common depigmentation disorder of the skin. Currently, its therapy focuses on the halting of the immune response and stimulation of the regenerative processes, leading to the restoration of normal melanocyte function. Platelet-rich plasma (PRP) represents a safe and cheap [...] Read more.
Vitiligo is the most common depigmentation disorder of the skin. Currently, its therapy focuses on the halting of the immune response and stimulation of the regenerative processes, leading to the restoration of normal melanocyte function. Platelet-rich plasma (PRP) represents a safe and cheap regenerative therapy option, as it delivers a wide spectrum of native growth factors, cytokines and other bioactive molecules. The aim of this study was to develop a simple delivery system to prolong the effects of the bioactive molecules released from platelets. The surface of electrospun and centrifugally spun poly-ε-caprolactone (PCL) fibrous scaffolds was functionalized with various concentrations of platelets; the influence of the morphology of the scaffolds and the concentration of the released platelet-derived bioactive molecules on melanocytes, was then assessed. An almost two-fold increase in the amount of the released bioactive molecules was detected on the centrifugally spun vs. electrospun scaffolds, and a sustained 14-day release of the bioactive molecules was demonstrated. A strong concentration-dependent response of melanocyte to the bioactive molecules was observed; higher concentrations of bioactive molecules resulted in improved metabolic activity and proliferation of melanocytes. This simple system improves melanocyte viability, offers on-site preparation and is suitable for prolonged topical PRP administration. Full article
(This article belongs to the Special Issue Smart Nanomaterials in Tissue Engineering: Preparation, Applications, Challenges and Prospects)
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Review

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25 pages, 3651 KiB  
Review
Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications
by Mohadeseh Zare, Pooya Davoodi and Seeram Ramakrishna
Nanomaterials 2021, 11(4), 933; https://doi.org/10.3390/nano11040933 - 6 Apr 2021
Cited by 44 | Viewed by 5719
Abstract
Shape memory polymers (SMPs) as a relatively new class of smart materials have gained increasing attention in academic research and industrial developments (e.g., biomedical engineering, aerospace, robotics, automotive industries, and smart textiles). SMPs can switch their shape, stiffness, size, and structure upon being [...] Read more.
Shape memory polymers (SMPs) as a relatively new class of smart materials have gained increasing attention in academic research and industrial developments (e.g., biomedical engineering, aerospace, robotics, automotive industries, and smart textiles). SMPs can switch their shape, stiffness, size, and structure upon being exposed to external stimuli. Electrospinning technique can endow SMPs with micro-/nanocharacteristics for enhanced performance in biomedical applications. Dynamically changing micro-/nanofibrous structures have been widely investigated to emulate the dynamical features of the ECM and regulate cell behaviors. Structures such as core-shell fibers, developed by coaxial electrospinning, have also gained potential applications as drug carriers and artificial blood vessels. The clinical applications of micro-/nanostructured SMP fibers include tissue regeneration, regulating cell behavior, cell growth templates, and wound healing. This review presents the molecular architecture of SMPs, the recent developments in electrospinning techniques for the fabrication of SMP micro-/nanofibers, the biomedical applications of SMPs as well as future perspectives for providing dynamic biomaterials structures. Full article
(This article belongs to the Special Issue Smart Nanomaterials in Tissue Engineering: Preparation, Applications, Challenges and Prospects)
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