Advances in Cardiac Physiology and Pathophysiology

A special issue of Physiologia (ISSN 2673-9488).

Deadline for manuscript submissions: 1 April 2025 | Viewed by 624

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School of Health Sciences, Liverpool Hope University, Liverpool L16 9JD, UK
Interests: cardiac physiology; strength and conditioning; anabolic steroids; supplementation
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Special Issue Information

Dear Colleagues,

Cardiac structure and functions have long been shown to adapt in response to a broad range of stimuli. Disease states, acute and chronic exercise training, drugs and supplements for health, and performance-enhancing and recreational drugs can all impact cardiac structure and function.

Similar structural and functional responses can be observed in response to these different stimuli. Therefore, appreciating the scale and type of adaptations that occur and how these responses translate into health and performance outcomes are important aspects for cardiac physiologists to understand.

Thus, the aim of this Special Issue is to highlight the scale and breadth of structural and functional changes that can occur in response to a broad spectrum of stimuli and how they impact health and performance outcomes.

Dr. Peter Angell
Guest Editor

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Keywords

  • cardiac structure and functions
  • disease states
  • acute and chronic exercise training
  • drugs

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Published Papers (1 paper)

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Research

19 pages, 1146 KiB  
Article
Isometric Fatigue Resistance of Lumbar Extensors and Cardiovascular Strain in Lower Back Pain Patients Are Associated with Angiotensin-Converting Enzyme and Tenascin-C Gene Polymorphisms
by Martin Flück, Paola Valdivieso, Marie-Noëlle Giraud and Barry Kim Humphreys
Physiologia 2024, 4(3), 286-304; https://doi.org/10.3390/physiologia4030017 - 31 Aug 2024
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Abstract
Background: We tested whether gene polymorphisms for angiotensin-converting enzyme (ACE, rs1799752) and tenascin-C (TNC, rs2104772) are associated with variability in fatigue resistance and metabolic strain during static lumbar exercise through interactions with chronic nonspecific lower back pain and habitual physical exercise levels (PA). [...] Read more.
Background: We tested whether gene polymorphisms for angiotensin-converting enzyme (ACE, rs1799752) and tenascin-C (TNC, rs2104772) are associated with variability in fatigue resistance and metabolic strain during static lumbar exercise through interactions with chronic nonspecific lower back pain and habitual physical exercise levels (PA). Methods: Forty-eight patients and matched controls performed an isometric endurance test for lumbar extensors. Metabolic strain to longissimus muscle (oxygen saturation, lactate) and cardiovascular system (muscle hemoglobin, blood pressure) and holding time were monitored. Subjects were genotyped for rs1799752 (II, ID, DD) and rs2104772 (AA, AT, TT). Associations of variance with group, genotype, and PA were analyzed under a 5% false discovery rate. Results: The holding time was lower in patients than in controls (150.9 vs. 188.6 s). This difference was associated with both genotypes, as patients with DD-rs1799752-genotype (p = 0.007) and TT-rs2104772-genotype (p = 0.041) showed lower fatigue resistance. Muscle deoxygenation during exercise varied in positive association with the rs2104772-genotype and PA (p = 0.010, η2 = 0.236). Mean arterial blood pressure (p = 0.028, η2 = 0.108) and recovery of hemoglobin concentration (p = 0.003, η2 = 0.907) demonstrated complex group x rs2104772 interactions. Conclusions: Polymorphisms rs1799752 and rs2104772 influence back pain-related variability in lumbar fatigue resistance. rs2104772 was linked to cardiovascular strain during isometric exercise and recovery via muscle perfusion. Full article
(This article belongs to the Special Issue Advances in Cardiac Physiology and Pathophysiology)
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