Bioinformatic Approaches to Understand Skeletal Muscle Adaptation
A special issue of Physiologia (ISSN 2673-9488).
Deadline for manuscript submissions: closed (28 April 2023) | Viewed by 3365
Special Issue Editors
Interests: integrative physiology; skeletal muscle; spaceflight; bed rest; microgravity; exercise; training
Special Issue Information
Dear Colleagues,
Skeletal muscle demonstrates remarkable remodelling, displaying hypertrophy in response to loading (e.g., exercise) and atrophy in response to unloading (e.g., disuse, spaceflight), ageing and/or disease. While reductionist analyses (e.g., PCR) have been invaluable for identifying key molecular regulators of atrophy/hypertrophy, phenotypic adaptations arise from highly coordinated and diverse molecular signals and, thus, cannot be fully explained on the basis of single molecular changes. The application of omics (e.g., transcriptomics, proteomics, metabolomics) offers a judicious approach that overcomes the limitations of reductionist methods by permitting global analysis, in which thousands of molecules are identified. Subsequent application of sophisticated informatic pipelines can identify and quantitively link molecular targets and molecular networks to physiological outcomes, thereby holding great promise to expedite our systems-level understanding of muscle atrophy/hypertrophy.
Thus, the aim of this Special Issue is to highlight the utilisation and application of -omic and/or informatic approaches for revealing the molecular regulation of muscle adaptation. We encourage the submission of original research articles, reviews and -omic meta-analyses on this topic.
Dr. Rodrigo Fernandez-Gonzalo
Dr. Colleen S. Deane
Guest Editors
Manuscript Submission Information
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Keywords
- skeletal muscle
- omics
- informatics
- atrophy
- hypertrophy
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