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Design and Application of Nanosensor Arrays

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Nanosensors".

Deadline for manuscript submissions: 10 August 2026 | Viewed by 2636

Special Issue Editors


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Guest Editor
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Interests: nanotechnology; sensor arrays; cell phenotyping; high-throughput screening; cancer diagnosis; anti-cancer therapy; adoptive cell therapy; cancer immunology

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Guest Editor
Laboratoire Interfaces Traitements Organisation et DYnamique des Systèmes, (ITODYS-CNRS/UMR7086, Paris Cité University), Sorbonne University, Paris, France
Interests: nanosensors
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Special Issue Information

Dear Colleagues,

Nanosensor arrays, with their remarkable ability to detect subtle changes in complex mixtures, are revolutionizing multiple fields. In recent years, these arrays have benefited from new technologies, including molecular, bioconjugate, and nanomaterial innovations, which enhance their functionality and application scope. This technological synergy has resulted in a powerful set of tools pivotal for advancing biomedical objectives and improving quality of life.

The exceptional sensitivity and specificity of nanosensor arrays enable them to detect and measure minute quantities of substances. In medical diagnostics, these arrays can identify biomarkers indicative of diseases at their earliest stages, such as detecting early signs of cancer or infectious diseases, facilitating early intervention and significantly improving patient outcomes. Their application extends to environmental monitoring, where they play a critical role in detecting low concentrations of pollutants, thereby ensuring environmental safety and compliance with regulatory standards.

This Special Issue encompasses a comprehensive range of transductions in sensor design, including optical, electrical, and electrochemical methods, to highlight the versatility of nanosensor arrays. Additionally, the issue aims to address the application of nanosensor arrays in gas sensing, emphasizing their role in identification and quantification of various gas molecules in environmental. The description underscores the physical particularities of sensors at the nanoscale, such as high surface area-to-volume ratio, electrical conductivity, unique magnetic properties, and quantum effects, which can significantly impact the performance and sensitivity of bulk materials used in sensor applications.

This Special Issue seeks innovative works on a wide range of research topics, spanning both the fundamental design of sensor arrays and novel applications of nanosensors, including results from industry and academic/industrial collaborations. Topics of interest include, but are not limited to, the following:

  • Design of nanosensor arrays;
  • Nanosensor arrays in biomedical applications;
  • Nanosensor arrays in medical diagnoses;
  • Nanosensor arrays for high-throughput screening;
  • Nanosensor arrays in microfluidics;
  • Nanosensor arrays in environmental monitoring;
  • Nanosensor arrays for cell phenotyping;
  • Nanosensor arrays in drug discovery.

Dr. Yingying Geng
Dr. Abdelhafed Taleb
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanosensor
  • biomedical
  • environmental monitoring
  • cell phenotyping
  • drug discovery

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Published Papers (2 papers)

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Research

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15 pages, 2633 KB  
Article
A Sensitive Multichannel Fluorescent Polymer Sensor Array for the Detection of Protein Fluctuations in Serum
by Junwhee Yang, Colby Alves, Kanwal Nazir, Mingdi Jiang, Nicolas Araujo and Vincent M. Rotello
Sensors 2026, 26(8), 2308; https://doi.org/10.3390/s26082308 - 9 Apr 2026
Viewed by 837
Abstract
Serum contains diverse proteins whose concentrations vary with pathological conditions such as cancer, liver disease, neurological disorder, and infections. Conventional methods like serum protein electrophoresis (SPEP) and enzyme-linked immunosorbent assay (ELISA) are gold standards for protein identification; however, they are time-consuming and can [...] Read more.
Serum contains diverse proteins whose concentrations vary with pathological conditions such as cancer, liver disease, neurological disorder, and infections. Conventional methods like serum protein electrophoresis (SPEP) and enzyme-linked immunosorbent assay (ELISA) are gold standards for protein identification; however, they are time-consuming and can miss abnormal serum protein levels. Inspired by chemical nose sensing based on selective sensor–analyte interactions, we synthesized five pyrene-conjugated fluorescent polymers (PFPs) with distinct side-chain head groups to construct a multichannel fluorescence sensor array. These polymers were screened for sensitivity to changes in serum protein levels using linear discriminant analysis (LDA), a machine learning method. This process led to the successful discovery of two PFPs that effectively detect protein level fluctuations. These PFPs provided a sensitive sensor array capable of generating a high-content response pattern (fingerprint) with six fluorescence channels. This sensor array successfully discriminated protein level fluctuations in serum with 98% jackknife classification accuracy and 95% unknown identification accuracy. This polymer sensor array holds strong potential as a diagnostic tool for serum-based samples and can be extended to other applications related to protein identification. Full article
(This article belongs to the Special Issue Design and Application of Nanosensor Arrays)
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Review

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34 pages, 4478 KB  
Review
A Review on Hierarchical Nanostructures for Electrochemical Sensors
by Safia Dassallem, Khalid Nouneh, Yanpeng Xue, Domenica Tonelli and Abdelhafed Taleb
Sensors 2026, 26(1), 73; https://doi.org/10.3390/s26010073 - 22 Dec 2025
Cited by 1 | Viewed by 1327
Abstract
In recent years, researchers have significantly increased their exploration of nanomaterials, primarily due to their exceptional and distinctive electrochemical properties. Hierarchical nanostructured materials have become a prevalent component in electrochemical sensors owing to their numerous advantages, including abundant open diffusion channels, diverse junction [...] Read more.
In recent years, researchers have significantly increased their exploration of nanomaterials, primarily due to their exceptional and distinctive electrochemical properties. Hierarchical nanostructured materials have become a prevalent component in electrochemical sensors owing to their numerous advantages, including abundant open diffusion channels, diverse junction interfaces, and a highly exposed surface area. This review provides a comprehensive overview of the potential of hierarchical nanomaterials as electrode modifiers, highlighting their capacity to enhance device performance. The introduction section sets the context by addressing the challenges and recent advancements in the field of hierarchical nanomaterials, emphasizing their promise for electrochemical sensor applications, and outlining the diverse research directions that are currently being explored. In the following section, a range of strategies and techniques for synthesizing hierarchical nanomaterials are outlined, with an emphasis on the impact of various parameters on their properties. Subsequently, the characteristics and performance of diverse hierarchical nanomaterials as electrode modifiers for electrochemical sensor applications are examined. Ultimately, the primary aspects and challenges of hierarchical nanomaterials in the domain of electroanalysis are reported, followed by a discussion of their future development. Full article
(This article belongs to the Special Issue Design and Application of Nanosensor Arrays)
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