Application of Raman Spectroscopy as Sensors for Direct in Vivo/in Situ Investigation
A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".
Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 3086
Special Issue Editor
Special Issue Information
Dear Colleagues,
Raman spectroscopy is a non-invasive/non-destructive technique that can provide qualitative and quantitative information on the chemical content of samples. Although the Raman process is exceptionally weak, the high specificity and sensitivity of the optical, non-touching, signal are of interest for both in situ and in vivo measurements. The development of lasers and time-resolved techniques has provided us with coherent anti-Stokes Raman spectroscopy (CARS), stimulated Raman scattering (SRS), terahertz Raman spectroscopy, hyper Raman spectroscopy and time-resolved Raman spectroscopy. These fast techniques can be used to monitor (bio)-chemical events in real time, opening up a wide range of applications such as in point-of-care diagnosis, in situ identification of food contaminants, and detection of narcotics and terrorism agents (viruses, explosives), surveillance of combustion processes or life observation of biomolecular action at different scales. Raman spectroscopy offers key advantages in the field of sensor development, such as sensitive and label-free identification of (bio)chemical compounds through their unique vibrational “fingerprints”, minimal sample preparation, user-friendliness, and miniaturization potential. Moreover, powerful Raman techniques, such as surface-enhanced Raman scattering (SERS), surface-enhanced resonance Raman scattering (SERRS), tip-enhanced Raman scattering (TERS) provide strong signal enhancement opening up for even more applications. The combination of Raman spectroscopy with other techniques has been shown to give exceptionally good sensitivity and specificity.
For this Special Issue, we invite both reviews and original research articles discussing novel Raman-based (bio)chemical time-resolved sensing techniques that can be applied to in situ/in vivo applications for analyte detection, quantification, surveillance, or mapping. Research articles may focus on the use of Raman-based sensors in biological analysis, medical diagnostics, illicit drug detection, combustion science, public safety, or food and water quality inspection. Raman spectroscopic applications involving biofilms, lab-on-chip and organ-on-chip, or Raman combined with other techniques are of high interest for this Special Issue. Reviews must offer a critical and up-to-date overview of the state of the art in a particular application, or discuss present and future challenges of Raman-based sensors (limit of detection, multiplexing, detection in complex matrices, time, etc.).
Should you require clarifications, or wish to discuss your submission in advance, we encourage you to contact us. We are looking forward to receiving your contribution to this Special Issue.
Prof. Dr. Kerstin Ramser
Guest Editor
Manuscript Submission Information
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Keywords
- Time-resolved Raman spectroscopy
- Stimulated Raman scattering
- Hyper Raman spectroscopy
- Coherent anti-Stokes Raman spectroscopy
- Terahertz Raman spectroscopy
- Surface-enhanced Raman spectroscopy
- Tip-enhanced Raman spectroscopy
- Lab-on-chip, organ-on-chip, in situ, in vivo, and real-time investigations
