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Disposable Optical Biosensors
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Disposable Optical Biosensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 16691

Special Issue Editor

Prof. Dr. Tobias Werner

E-Mail Website
Guest Editor
Institute of Analytical Chemistry, University of Applied Science Mannheim, Mannheim, Germany
Interests: optical sensors; biosensors; analytical chemistry; clinical chemistry; fluorophores

Special Issue Information

Dear Colleagues,

Within the field of biosensor development, disposable optical devices play a growing role in certain areas, including early-stage disease diagnostics, point-of-care applications, therapeutic monitoring, environmental analysis, food and agriculture control, or in the field of bioprocess monitoring. Along with the trend to develop small and easy to handle smart analytical tools, the improvement in materials, as well as optics and electronics, have enabled the development of efficient disposable biosensors for the detection of biomolecules in different environments.

This Special Issue of Sensors entitled “Disposable Optical Biosensors” will focus on all aspects of research and development related to these topics. Both reviews and original research articles that focus on the design and experimental verification of disposable optical biosensors are welcome. In addition, the submission of papers reporting on interesting results of testing “Disposable Optical Biosensors” in the real world are highly appreciated.

Regardless of the optical measuring technique or principle that will be reported, we invite and encourage your participation in this Special Issue, if the results of your work are based on label-free or label-based sensing, immunosensing, fluorescence or luminescence, surface plasmon resonance, fiber optics, evanescent wave, interference spectroscopy, surface-enhanced Raman scattering, optical platforms such as lab-on-a-chip, and microfluidics incorporating intracellular fluorescent probes for biosensing. Further high-quality contributions from other fields of “Disposable Optical Biosensors” will also be considered.

Particular topics of interest include, but are not limited to, the following:

  • Fiber-optical biosensors
  • Optical biosensors in small devices
  • Microfluidics and optically integrated biosensor systems (lab-on-a-chip)
  • Biosensors in disposable devices such as sensors for disposable bioreactors
  • Metabolite monitoring
  • Immobilized luminophores, receptors, and proteins
  • Wearable biosensors
  • Enzyme-based biosensors
  • Biomedical analysis
  • Point of care device

Prof. Dr. Tobias Werner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fiber-optical biosensors
  • Fluorescence-based biosensors in small devices
  • Fluorescence proteins
  • Förster resonance energy transfer (FRET)
  • Microfluidics and Optical integrated biosensor systems (lab-on-a-chip)
  • Disposable devices
  • Immobilized luminophores, receptors, and proteins
  • Wearable biosensors

Published Papers (2 papers)

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Research

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15 pages, 2801 KiB  
Article
A Novel Genetically Encoded Single Use Sensory Cellular Test System Measures Bicarbonate Concentration Changes in Living Cells
by Kevin Bernhard, Cordula Stahl, Regina Martens and Manfred Frey
Sensors 2020, 20(6), 1570; https://doi.org/10.3390/s20061570 - 11 Mar 2020
Cited by 2 | Viewed by 4425
Abstract
Bicarbonate plays a central role in human physiology from cellular respiration to pH homeostasis. However, so far, the measurement of bicarbonate concentration changes in living cells has only been possible by measuring intracellular pH changes. In this article, we report the development of [...] Read more.
Bicarbonate plays a central role in human physiology from cellular respiration to pH homeostasis. However, so far, the measurement of bicarbonate concentration changes in living cells has only been possible by measuring intracellular pH changes. In this article, we report the development of a genetically encoded pH-independent fluorescence-based single-use sensory cellular test system for monitoring intracellular bicarbonate concentration changes in living cells. We describe the usefulness of the developed biosensor in characterizing the bicarbonate transport activities of anionophores—small molecules capable of facilitating the membrane permeation of this anion. We also demonstrate the ability of the bicarbonate sensory cellular test system to measure intracellular bicarbonate concentration changes in response to activation and specific inhibition of wild-type human CFTR protein when co-expressed with the bicarbonate sensing and reporting units in living cells. A valuable benefit of the bicarbonate sensory cellular test system could be the screening of novel anionophore library compounds for bicarbonate transport activity with efficiencies close to the natural anion channel CFTR, which is not functional in the respiratory epithelia of cystic fibrosis patients. Full article
(This article belongs to the Special Issue Disposable Optical Biosensors)
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Review

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42 pages, 3304 KiB  
Review
Sensing Senses: Optical Biosensors to Study Gustation
by Elena von Molitor, Katja Riedel, Mathias Hafner, Rüdiger Rudolf and Tiziana Cesetti
Sensors 2020, 20(7), 1811; https://doi.org/10.3390/s20071811 - 25 Mar 2020
Cited by 7 | Viewed by 11903
Abstract
The five basic taste modalities, sweet, bitter, umami, salty and sour induce changes of Ca2+ levels, pH and/or membrane potential in taste cells of the tongue and/or in neurons that convey and decode gustatory signals to the brain. Optical biosensors, which can [...] Read more.
The five basic taste modalities, sweet, bitter, umami, salty and sour induce changes of Ca2+ levels, pH and/or membrane potential in taste cells of the tongue and/or in neurons that convey and decode gustatory signals to the brain. Optical biosensors, which can be either synthetic dyes or genetically encoded proteins whose fluorescence spectra depend on levels of Ca2+, pH or membrane potential, have been used in primary cells/tissues or in recombinant systems to study taste-related intra- and intercellular signaling mechanisms or to discover new ligands. Taste-evoked responses were measured by microscopy achieving high spatial and temporal resolution, while plate readers were employed for higher throughput screening. Here, these approaches making use of fluorescent optical biosensors to investigate specific taste-related questions or to screen new agonists/antagonists for the different taste modalities were reviewed systematically. Furthermore, in the context of recent developments in genetically encoded sensors, 3D cultures and imaging technologies, we propose new feasible approaches for studying taste physiology and for compound screening. Full article
(This article belongs to the Special Issue Disposable Optical Biosensors)
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