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Graphene-Based Sensors for Pharmaceutical and Biomedical Analysis
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Graphene-Based Sensors for Pharmaceutical and Biomedical Analysis

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 7530

Special Issue Editor

Prof. Dr. Raluca-Ioana Stefan-van Staden

E-Mail Website
Guest Editor
Head of Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, 300569 Timișoara, Romania
Interests: electrochemical sensors; chemistry; graphene; biomarkers; gastrointestinal cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmaceutical and biomedical analyses require highly sensitive and selective methods. Electrochemical sensors based on graphene materials are a very good alternative for standard methods of analysis performed in clinical and pharmaceutical laboratories. This Special Issue will emphasize new electroanalytical methods based on graphene sensors for pharmaceutical and biomedical analysis.

Prof. Dr. Raluca-Ioana Stefan-van Staden
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical sensors
  • pharmaceutical analysis
  • biomedical analysis

Published Papers (2 papers)

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12 pages, 2083 KiB  
Article
Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors
by Raluca-Ioana Stefan-van Staden, Damaris-Cristina Gheorghe, Viorel Jinga, Cristian Sorin Sima and Marius Geanta
Sensors 2020, 20(8), 2420; https://doi.org/10.3390/s20082420 - 24 Apr 2020
Cited by 12 | Viewed by 2870
Abstract
Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and [...] Read more.
Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and tumor tissue samples may save lives. Four biomarkers, p53, E-cadherin, bladder tumor antigen (BTA), and hyaluronic acid were considered for the screening tests using stochastic needle sensors. Three stochastic needle sensors, based on graphite powder and modified with three types of chitosan, were designed and characterized for the screening test. The proposed sensors showed low limits of quantification, and high sensitivity and selectivity levels. The recoveries of p53, E-cadherin, BTA, and hyaluronic acid in whole blood samples and tissue samples were higher than 95.00% with a relative standard deviation lower than 1.00%. Full article
(This article belongs to the Special Issue Graphene-Based Sensors for Pharmaceutical and Biomedical Analysis)
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13 pages, 3709 KiB  
Letter
Stone Paper as a New Substrate to Fabricate Flexible Screen-Printed Electrodes for the Electrochemical Detection of Dopamine
by Codruta Varodi, Florina Pogacean, Marin Gheorghe, Valentin Mirel, Maria Coros, Lucian Barbu-Tudoran, Raluca-Ioana Stefan-van Staden and Stela Pruneanu
Sensors 2020, 20(12), 3609; https://doi.org/10.3390/s20123609 - 26 Jun 2020
Cited by 16 | Viewed by 4217
Abstract
Flexible screen-printed electrodes (HP) were fabricated on stone paper substrate and amperometrically modified with gold nanoparticles (HP-AuNPs). The modified electrode displayed improved electronic transport properties, reflected in a low charge-transfer resistance (1220 Ω) and high apparent heterogeneous electron transfer rate constant (1.94 × [...] Read more.
Flexible screen-printed electrodes (HP) were fabricated on stone paper substrate and amperometrically modified with gold nanoparticles (HP-AuNPs). The modified electrode displayed improved electronic transport properties, reflected in a low charge-transfer resistance (1220 Ω) and high apparent heterogeneous electron transfer rate constant (1.94 × 10−3 cm/s). The voltammetric detection of dopamine (DA) was tested with HP and HP-AuNPs electrodes in standard laboratory solutions (pH 6 phosphate-buffered saline (PBS)) containing various concentrations of analyte (10−7–10−3 M). As expected, the modified electrode exhibits superior performances in terms of linear range (10−7–10−3 M) and limit of detection (3 × 10−8 M), in comparison with bare HP. The determination of DA was tested with HP-AuNPs in spiked artificial urine and in pharmaceutical drug solution (ZENTIVA) that contained dopamine hydrochloride (5 mg/mL). The results obtained indicated a very good DA determination in artificial urine without significant matrix effects. In the case of the pharmaceutical drug solution, the DA determination was affected by the interfering species present in the vial, such as sodium metabisulfite, maleic acid, sodium chloride, and propylene glycol. Full article
(This article belongs to the Special Issue Graphene-Based Sensors for Pharmaceutical and Biomedical Analysis)
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