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Microfluidic Systems for Global Health and Point of Care Testing

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2728

Special Issue Editor


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Guest Editor
Department of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221, USA
Interests: microfluidics; frugal science

Special Issue Information

Dear Colleagues,

The recent global pandemic (COVID-19) has exposed some of the key limitations in our current health management system. Existing approaches rely on the use of bulky, power-intensive, complex, and expensive instrumentation that restricts the scale-up required for widespread and rapid testing. This introduces a considerable time lag between sample collection, diagnosis, and the implementation of countermeasures. A need, therefore, exists for inexpensive and robust tools that can be broadly deployed to accelerate diagnosis and provide real-time data to better inform decision making. Microfluidic technology enables the miniaturization and automation of several analytical processes that would conventionally require bulky and expensive benchtop laboratory instruments. It has enabled researchers to perform numerous parallel experiments rapidly while consuming minimal reagents in an extremely portable form factor with significant energy and cost savings. This has led to the emergence of the so-called “lab-on-chip” devices, making significant strides in diverse areas ranging from grand challenges such as water purification to fundamental research such as genetic analysis, organ on a chip, electrophoresis, molecular analysis, and pathogen detection. In this Special Issue, we seek original research papers, short communications, and review papers centered around the recent developments in microfluidics for global health and point of care testing.

Dr. Aashish Priye
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • microfluidics
  • lab-on-a-chip
  • point-of-care diagnostics
  • nucleic acid amplification tests
  • paper microfluidics
  • polymerase chain reaction (PCR)
  • loop-mediated isothermal amplification (LAMP)
  • biomarkers
  • single-cell analysis

Published Papers (1 paper)

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Research

9 pages, 1229 KiB  
Communication
Simulating the Effect of Gut Microbiome on Cancer Cell Growth Using a Microfluidic Device
by Ekansh Mittal, Grace Cupp and Youngbok (Abraham) Kang
Sensors 2023, 23(3), 1265; https://doi.org/10.3390/s23031265 - 22 Jan 2023
Cited by 1 | Viewed by 2321
Abstract
The imbalance in the gut microbiome plays a vital role in the progression of many diseases, including cancer, due to increased inflammation in the body. Since gut microbiome-induced inflammation can serve as a novel therapeutic strategy, there is an increasing need to identify [...] Read more.
The imbalance in the gut microbiome plays a vital role in the progression of many diseases, including cancer, due to increased inflammation in the body. Since gut microbiome-induced inflammation can serve as a novel therapeutic strategy, there is an increasing need to identify novel approaches to investigate the effect of inflammation instigated by gut microbiome on cancer cells. However, there are limited biomimetic co-culture systems that allow testing of the causal relationship of the microbiome on cancer cells. Here we developed a microfluidic chip that can simulate the interaction of the gut microbiome and cancer cells to investigate the effects of bacteria and inflammatory stress on cancer cells in vitro. To test the microfluidic chip, we used colorectal cancer cells, as an increased microbiome abundance has been associated with poor outcomes in colorectal cancer. We cultured colorectal cancer cells with Bacillus bacteria or lipopolysaccharide (LPS), a purified bacterial membrane that induces a significant inflammatory response, in the microfluidic device. Our results showed that both LPS and Bacillus significantly accelerated the growth of colorectal cancer cells, therefore supporting that the increased presence of certain bacteria promotes cancer cell growth. The microfluidic device included in this study may have significant implications in identifying new treatments for various cancer types in the future. Full article
(This article belongs to the Special Issue Microfluidic Systems for Global Health and Point of Care Testing)
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