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Recent Advances in High Sensitive Point-of-Care (POC) Diagnostics
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Recent Advances in High Sensitive Point-of-Care (POC) Diagnostics

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (15 March 2020) | Viewed by 7889

Special Issue Editor

Prof. Dr. Jeong Hoon Lee

E-Mail Website
Guest Editor
Electrical Engineering, Kwangwoon University, Seoul 01897, Republic of Korea
Interests: bioelectronics; sensor; nanotechnology; paper-based diagnostics (U-Pad)

Special Issue Information

Dear Colleagues,
Point-of-care (POC) diagnostics have unique advantages in terms of portability and ease of use; therefore, POC diagnostics are considered the best candidates that meet the purpose of on-site diagnostics where medical diagnostic testing needs. Especially, if high sensitive POC device can be realized, one can apply POC device more widely for medical diagnosis, virus detection, food safety and environmental monitoring, etc.
This Special Issue aims to promote exchanges of ideas and knowledge about recent POC diagnostics, focusing on materials, devices and applications.
This Special Issue includes, but is not limited to, the following:
  • Novel point-of-care (POC) materials
  • Digital microfluidics
  • High sensitive electrical devices
  • High sensitive MEMS devices
  • Novel sample preparation devices
  • Acoustic based sample separations
  • Device platform using non-invasive human samples (urine/saliva/sweat)
  • Wearable devices for POCT
  • Chemical sensing applications using POCT
  • Biosensing applications using POCT
  • Novel target marker for POCT

Prof. Dr. Jeong Hoon Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Point-of-care testing 
  • Biosensor
  • Chemical sensor
  • Digital microfluidics
  • Wearable devices

Published Papers (2 papers)

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Research

12 pages, 2489 KiB  
Article
Highly Sensitive Micropatterned Interdigitated Electrodes for Enhancing the Concentration Effect Based on Dielectrophoresis
by Hye Jin Kim, Heeju Ahn, David S. Lee, Dongsung Park, Jae Hyun Kim, Jinsik Kim, Dae Sung Yoon and Kyo Seon Hwang
Sensors 2019, 19(19), 4152; https://doi.org/10.3390/s19194152 - 25 Sep 2019
Cited by 8 | Viewed by 3153
Abstract
The concentration effect of dielectrophoresis (DEP) enables detection of biomolecules with high sensitivity. In this study, microstructures were patterned between the interdigitated microelectrodes (IMEs) to increase the concentration effect of DEP. The microstructures increased the electric field gradient ( [...] Read more.
The concentration effect of dielectrophoresis (DEP) enables detection of biomolecules with high sensitivity. In this study, microstructures were patterned between the interdigitated microelectrodes (IMEs) to increase the concentration effect of DEP. The microstructures increased the electric field gradient ( ∇ | E 2 | ) between the IMEs to approximately 6.61-fold higher than in the bare IMEs with a gap of 10 μm, resulting in a decreased optimal voltage to concentrate amyloid beta 42 (Aβ42, from 0.8 Vpp to 0.5 Vpp) and tau-441 (from 0.9 Vpp to 0.6 Vpp) between the IMEs. Due to the concentration effect of DEP, the impedance change in the optimal condition was higher than the values in the reference condition at 2.64-fold in Aβ42 detection and at 1.59-fold in tau-441 detection. This concentration effect of DEP was also verified by counting the number of gold (Au) particles which conjugated with the secondary antibody. Finally, an enhanced concentration effect in the patterned IMEs was verified by measuring the impedance change depending on the concentration of Aβ42 and tau-441. Our results suggest that microstructures increase the concentration effect of DEP, leading to enhanced sensitivity of the IMEs. Full article
(This article belongs to the Special Issue Recent Advances in High Sensitive Point-of-Care (POC) Diagnostics)
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11 pages, 4160 KiB  
Article
Multiplexed Paper Microfluidics for Titration and Detection of Ingredients in Beverages
by Alisha Prasad, Tiffany Tran and Manas Ranjan Gartia
Sensors 2019, 19(6), 1286; https://doi.org/10.3390/s19061286 - 14 Mar 2019
Cited by 16 | Viewed by 4365
Abstract
Food safety and access to systematic approaches for ensuring detection of food hazards is an important issue in most developing countries. With the arrival of paper-based analytical devices (µPADs) as a promising, rapid, easy-to-use, and low-cost analytical tool, we demonstrated a simple microfluidic-based [...] Read more.
Food safety and access to systematic approaches for ensuring detection of food hazards is an important issue in most developing countries. With the arrival of paper-based analytical devices (µPADs) as a promising, rapid, easy-to-use, and low-cost analytical tool, we demonstrated a simple microfluidic-based titration study for the analysis of packaged fruit juices. Similar, to the titration experiments using traditional glassware in chemistry laboratories, in this study the titration experiments were developed using paper microfluidics for the analysis of several analytes such as pH, vitamin C, sugars, and preservatives present in the packaged fruit juices. The allergen found commonly in dairy based mixtures and the non-pathogenic biochemical component responsible for food spoilage in cider based fruit juices were also determined. The results obtained using paper microfluidics were compared with those obtained using a conventional spectrophotometric technique. Finally, a paper microfluidics based multiplexed sensor was developed for the analysis of common nutritional ingredients, an allergen, and a non-pathogenic byproduct present in packaged fruit juices on a single platform. Overall, the results presented in this study reveal that the proposed paper microfluidic assisted colorimetric multiplexed sensor offers a quick and reliable tool for on-spot routine analysis for food safety applications. Full article
(This article belongs to the Special Issue Recent Advances in High Sensitive Point-of-Care (POC) Diagnostics)
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