Effects of Botulinum Toxin on Functional Recovery after Injuries of Nervous System
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 52482
Special Issue Editor
Interests: botulinum neurotoxins; neuropathic pain; peripheral nerve; motor function; functional recovery; animal model; glial cells; Schwann cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Botulinum toxins (BoNTs) are extensively used for their therapeutic efficacy in a variety of human pathologies, most of them difficult to treat with other drugs, characterized by excessive muscle contractions due to hypercholinergic dysfunctions. This effect resides in the capacity of BoNTs to block the cholinergic transmission at the neuromuscular junction. Nowadays, the list of human disorders in which treatments with BoNTs have produced, or are expected to produce, favorable results is long and continuously growing, comprising also pathologies where the expected therapeutic action is not only at the level of the neuromuscular junction, but it is also attributable to the interaction of the toxins with other structures, including peripheral nerves, spinal cord, central neurons, non-neural cells, and so on. In more recent years, a number of experimental and clinical studies provided positive evidences for the efficacy of BoNTs in facilitating motor and functional recovery after traumatic injuries of nervous systems. This Special Issue on “The Effect of Botulinum Toxin on Functional Recovery after Injuries of Nervous System” is particularly devoted to collecting the most recent research on the effects of BoNTs in all those conditions where impairments of motor function are the consequence of traumatic injuries on the nervous system. Both review and research articles are welcome, not only from animal studies but also from clinical trials or case reports. The ambitious purpose of this Special Issue is to provide an up-to-date picture of the state of art on the development of novel BoNT applications to ameliorate the functional recovery after motor impairment resulting from trauma to the brain, the spinal cord or the peripheral nerves, such as spasticity after stroke, paralysis after spinal cord injury, hemiparesis after peripheral nerves degeneration, and so on.
Dr. Siro Luvisetto
Guest Editor
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Keywords
- Botulinum neurotoxins
- Peripheral nerve injury
- Spinal cord injury
- Post-stroke spasticity
- Axonal regeneration
- Functional recovery
- Experimental models
- Clinical studies
- Rehabilitation
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