Foodborne Toxigenic Organisms: A Tribute to Professor Hannu Korkeala

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1322

Special Issue Editors


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Guest Editor
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland
Interests: botulism; botulinum neurotoxin; Clostridium botulinum; food safety

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Guest Editor
Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy
Interests: botulism; botulinum neurotoxins; Clostridium botulinum; BoNT-producing clostridia; food safety; food hygiene
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Special Issue Information

Dear Colleagues,

This Special Issue will focus on foodborne toxigenic organisms as a tribute to Professor Hannu Juhani Korkeala. Professor Korkeala is a distinguished Finnish veterinarian and one of the leading experts in food hygiene, epidemiology, and the prevention of foodborne diseases. His research explores a wide range of pathogens that cause food poisoning in humans. Korkeala’s groundbreaking work has advanced our understanding of genetic mechanisms, as, using molecular biology techniques, he has identified mechanisms that contribute to foodborne illness outbreaks and developed strategies to mitigate risks. His contributions have been instrumental in improving food hygiene, food safety, and epidemiology. Throughout his career, Professor Korkeala has held prestigious academic positions, including Head of the Department of Food and Environmental Hygiene at the University of Helsinki. His research has led to numerous international collaborations and projects, including work on C. botulinum and its toxins. His leadership has earned him numerous awards, including honorary memberships in the Finnish Veterinary Association and the Royal Swedish Agricultural Academy, as well as recognition from the German National Academy of Sciences Leopoldina. His work has not only shaped the field of food hygiene but also enhanced public health globally by addressing the challenges posed by pathogens in food supply within the One Health framework. With his exceptional talent for motivating others, he has attracted young researchers and students from around the world, significantly contributing to their educational programs.

Although Hannu has retired from the University of Helsinki, he remains an invaluable mentor to researchers and students entering the fields of foodborne pathogens, food hygiene, and public health.

For this Special Issue, we welcome diverse contributions, including reviews, research articles,  that present a contemporary and comprehensive overview of knowledge pertaining to strategies to enhance food hygiene and safety.

Dr. Yagmur Derman
Dr. Fabrizio Anniballi
Guest Editors

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Keywords

  • foodborne toxigenic organisms
  • foodborne pathogens
  • food safety

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Published Papers (1 paper)

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Research

13 pages, 6695 KB  
Article
Features of the First Case of Foodborne Botulism Caused by Dual-Toxin Clostridium parabotulinum Subtype A1(B5) in Spain
by Sylvia Valdezate, Mónica Valiente, Gema Carrasco, María J. Medina-Pascual, María Isabel Hurtado, Maite Ruiz de Pipaón, Noelia Garrido, Carmen Paradas, José Ramón Hernández-Bello and Pilar Villalón
Toxins 2025, 17(9), 429; https://doi.org/10.3390/toxins17090429 - 27 Aug 2025
Viewed by 731
Abstract
The neurotoxin BoNT/B2 is the predominant Clostridium parabotulinum subtype in foodborne and infant botulism cases in Spain. This study characterizes a novel case of foodborne botulism in Spain caused by a dual-toxin A1(B5) strain. A 64-year-old male presented with acute, progressive flaccid paralysis [...] Read more.
The neurotoxin BoNT/B2 is the predominant Clostridium parabotulinum subtype in foodborne and infant botulism cases in Spain. This study characterizes a novel case of foodborne botulism in Spain caused by a dual-toxin A1(B5) strain. A 64-year-old male presented with acute, progressive flaccid paralysis including diplopia, dysphagia, and respiratory failure. Although botulism was not initially suspected, the patient recovered with supportive care and without antitoxin administration. Genomic characterization confirmed the presence of both bont/A1 and silent bont/B5 genes. The bont/A1 gene was associated with an orfX+ neurotoxin gene cluster, while the silent bont/B5 gene was in an ha+ cluster. Phylogenetic analysis of both bont/A1 and bont/B5 sequences showed 100% amino acid identity, respectively, to previously reported A1(B5) strains (e.g., CDC_69094, FE9504ACG). Multi-locus sequence typing (MLST) assigned the ST10, a genotype previously undetected in Spanish botulism cases, yet found in other European countries. This case highlights the importance of considering botulism in differential diagnosis due to its varied presentation and the significance of timely laboratory confirmation for effective management. The identification of this dual-toxin BoNT/A1(B5) orfX+/ha+ ST10 strain expands our understanding of C. botulinum epidemiology and genetic diversity in Spain. Full article
(This article belongs to the Special Issue Foodborne Toxigenic Organisms: A Tribute to Professor Hannu Korkeala)
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