65 Years On from Aflatoxin Discovery—a Themed Issue in Honor of Professor John D. Groopman
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 213
Special Issue Editors
Interests: biochemical toxicology; aflatoxin carcinogenesis; glutathione-mediated biotransformation of toxic chemicals.
Interests: chemical carcinogenesis; aflatoxin; chemoprevention; hepatocarcinogenesis; reactive oxygen; Keap1; Nrf2; sulforaphane; triterpenoids; biomarkers; clinical trials
Special Issue Information
Dear Colleagues,
Aflatoxins are a group of fungal metabolites produced primarily by certain strains of the common mold, Aspergillus; these include, in particular, A. flavus and A. parasiticus. Aflatoxins were discovered in the 1960s following the outbreak of liver toxicity in turkeys (so-called ‘Turkey X disease) and a nearly simultaneous outbreak of normally rare hepatocellular tumors in hatchery-reared rainbow trout, where the diets of both species were contaminated with Aspergillus. One specific form, Aflatoxin B1 (AFB1), is now widely recognized throughout the world to be one of the most potent known human liver carcinogens. In addition to cancer, hepatotoxicity, immune suppression, stunting, and delayed development have been reported to be aflatoxin-associated outcomes in humans and animals. Aflatoxin is certainly the most researched of the mycotoxins. Current inquiries seek to better understand the mechanistic underpinnings of these toxicities in human and veterinary settings, the factors leading to the elaboration of aflatoxins in foods and feeds, along with the likely impact of climate change on these processes and their distribution across the globe. Collectively, this knowledge will better inform risk analyses that aim to guide regulatory and interventional strategies to mitigate exposures and their sequalae. The development of biomarkers of internal dose (urinary metabolites and aflatoxin–albumin adducts) and early biological effects (aflatoxin-DNA adducts in urine and tissue), pioneered by Professor John D. Groopman, has contributed greatly to our understanding of the global public health consequences of aflatoxin contamination. This Special Issue of Toxins welcomes contributions that further refine our understanding across all aspects of aflatoxin toxicology.
Prof. Dr. David L. Eaton
Prof. Dr. Thomas W. Kensler
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epidemiology
- risk assessment
- mechanisms
- chemical carcinogenesis
- hepatotoxicity
- dietary exposure
- biomarkers
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
