Botulinum Toxins: Beyond the SNAP-25 Cleavage and New Insights on Pain Relief Mechanisms
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 227
Special Issue Editors
Interests: botulism; botulinum neurotoxins; antitoxins; in vivo; ex vivo; cell based assays
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Botulinum neurotoxins (BoNTs) have become a well-established treatment option in a wide range of excessive muscle contractility disorders and as such have been routinely used since decades to treat cervical dystonia, spastic conditions, blepharospasm, hyperhidrosis, and for cosmetic purposes. BoNTs are categorized into seven toxinotypes, two of which are in clinical use, with each toxinotype being divided into multiple subtypes. With the development of bioinformatic tools, new BoNT-like toxins have been identified in non-Clostridial organisms, in addition to the expanding indications of existing formulations. The increased understanding of their molecular biology as well as the design of recombinant BoNT form the basis to develop innovative BoNT-based therapeutics as well as research tools. An overview of the diverse mechanisms of action of the BoNT family along with their impact on the nociceptive pathways, through its central and peripheral activities, the molecular mechanisms of action in neurons, and general pharmacokinetic parameters are presented in this Special Issue providing a broader understanding of its actions. This Special Issue will allow the advanced understanding of their therapeutic potential in acute and chronic pain, while further experimental and clinical research is still required to validate the mechanisms of action experimentally.
Dr. Christine Rasetti-Escargueil
Dr. Stefano Palea
Guest Editors
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Keywords
- botulinum neurotoxin
- SNAP-25
- recombinant BoNTs
- acute pain
- chronic pain
- visceral pain
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