Detection and identification of biological toxins in international proficiency tests
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (30 June 2015) | Viewed by 112015
Special Issue Editors
Interests: botulinum neurotoxin; ricin; tetanus neurotoxin; Clostridium perfringens; Clostridium botulinum; Staphylococcus aureus enterotoxin (SE)
Special Issues, Collections and Topics in MDPI journals
Interests: botulinum neurotoxins, ricin, abrin and other protein biotoxins; variability and functionality of biotoxins; (multiplex-) detection of biotoxins; antibodies for research and therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Based on their characteristics, biological toxins are at the interface of classical biological and chemical agents: ricin and saxitoxin are prohibited substances under both, the Chemical Weapons Convention, and the Biological Weapons Convention, the latter one also prohibits bacterial toxins, such as botulinum neurotoxins (BoNT) and staphylococcal enterotoxins (SET). Generally, biological toxins are relevant in the security, health and food sectors. The relative ease in preparing some of the mentioned toxins and the worldwide availability of the biological sources constitutes them as potential agents of bioterrorism. However, biological toxins are also linked with natural intoxications, and some of them cause severe and recurrent diseases worldwide.
Although different technologies for toxin detection and analysis are in use, hardly any universally agreed upon “gold standard” methods, as well as no qualified reference materials, are available, and basic questions regarding standardized detection of these molecules are unresolved. While the importance of the mentioned biological toxins as potential agents of bioterrorism and as source of natural intoxications has been recognized, it is not clear, how well prepared laboratories are with respect to detection and identification of these toxins.
The European Union funded consortium EQuATox focuses, in-depth, on biological toxins and their intricacies with respect to detection, identification, structure, and function. The EQuATox project has, for the first time, gathered expert laboratories from the security, verification, health and food sectors to work on biological toxins. The project obtained highly important results with respect to reference materials, standardized detection and best practices in four proficiency tests focusing on ricin, saxitoxin, staphylococcal enterotoxin B and botulinum neurotoxins. The results will be highlighted in a series of articles in the Toxins Special Issue "Detection and identification of biological toxins in international proficiency tests".
Dr. Andreas Rummel
Dr. Brigitte G. Dorner
Guest editors
Note added by the Publisher: the Guest Editors were not involved in the editorial process for manuscripts on which they are authors. In this case, the editorial decisions were done by independent editorial board members.
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Keywords
- bacterial protein toxins
- proficiency test
- best practices
- ricin
- saxitoxin
- staphylococcal enterotoxin B
- botulinum neurotoxin
- reference material
- standardised detection
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