Cytokines and Cytokine Receptors in Inflammation and Immunity
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: 31 July 2025 | Viewed by 63
Special Issue Editors
Interests: immunity; immunomodulation; T cells; B cells; cytokines; epitopes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cytokines are a diverse group of cell-signaling soluble factors that play a key role regulating inflammation and immunity. Cytokines can be classified by different criteria such as function, producing cells, and structure. Major functional groups of cytokines are chemokines (cell homing and migration), interferons (defense against viruses), interleukins (relay signals from and to leukocytes), tumor necrosis factors (inflammation), and colony-stimulating factors (hematopoiesis). The biology of cytokines can be very elusive since their expression is highly controlled and usually brief. Moreover, they can act at different ranges (autocrine, paracrine, and endocrine signaling) and on multiple cells with contrasting outcomes (activation, proliferation, or differentiation). Furthermore, cytokine function is strongly impacted by the cellular and molecular context. Cytokine signaling is contingent on the expression of cognate cytokine receptors in the responding cells, which are often formed by more than one polypeptide chain. Interestingly, cytokine receptor chains can be shared by different cytokines. A relevant paradigm is that of the common cytokine receptor gamma-chain, γc, which used by interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Research into cytokines and cytokine receptors has an enormous translational potential. In this Special Issue, we invite contributions on any aspect related to the biology of cytokines and cytokine receptors including, but not limited to, signaling, gene expression and regulation, structure, homeostasis, physiopathology, and clinical applications.
Dr. Pedro A. Reche
Dr. Vassili Soumelis
Guest Editors
Manuscript Submission Information
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Keywords
- cytokine
- cytokine receptors
- chemokine
- inlammation
- immunity
- signaling
- immunotherapy
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