Nasal Immunity Against Virus Infection
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 15 May 2026 | Viewed by 127
Special Issue Editor
2. Clinical Microbiology Laboratory, Hospital of Circolo and Estabilshment Macchi, Varese, Italy
Interests: respiratory viruses; microbiology infection; SARS-CoV-2; nasal immunology; epidemiology; clinical microbiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue will address the general topic of nasal immunity, emphasizing imaging as a key tool that helps us to study the mechanisms underlying nasal immune responses. Advances in imaging technologies now enable high-resolution visualization of immune cell dynamics, tissue architecture, and molecular interactions within the nasal mucosa, offering unprecedented insight into how local immunity is organized and regulated. Topics will include the role of pattern recognition receptors (PRRs) in early viral detection, the structure and function of nasal-associated lymphoid tissue (NALT), the induction of local IgA responses and their coordination with systemic immunity, and the cytokine and chemokine signaling that shapes antiviral defence in the nasal mucosa. The issue will also examine nasal vaccination and mucosal vaccine development, including current nasal vaccines (such as those for influenza and SARS-CoV-2), their successes, challenges, and safety concerns, as well as the intranasal administration of antivirals, interferons, and RNA-based therapeutics. Emerging advances and future directions will explore tissue-resident immunity and its role in long-term nasal protection, the influence of the nasal microbiome on immune function and viral susceptibility, engineering NALT responses for universal respiratory virus vaccines, and translational and regulatory considerations for intranasal therapeutics.
Dr. Federica Novazzi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- virus–host
- viral life cycle
- viral replication
- imaging
- respiratory viruses
- nasal immunology
- type-I interferon
- type-III interferon
- proinflammatory cytokines
- age
- viral load
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