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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Computational Studies in Epidemiology and Evolution of Pandemic Virus

edited by

Francesco Filippini

and

Irene Righetto

submission deadline 25 Apr 2025 | 1 articles | Viewed by 15814 | Submission Open

Keywords: pandemic virus; avian influenza; coronavirus; SARS-CoV-2; immune escape; structural bioinformatics; variant; mutation; antiviral design; host jump; pathogenicity shift; antivirals design; epitope identification

(This special issue belongs to the Section General Virology)

Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons

edited by Ya-Fang Chiu and Bill Sugden

submission deadline 25 Apr 2025 | 2 articles | Viewed by 4708 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

Harnessing AI and Machine Learning for Antiviral Development

edited by

X. Frank Zhang

submission deadline 25 Apr 2025 | Viewed by 362 | Submission Open

Keywords: artificial intelligence; machine learning; antiviral therapies; personalized medicine; drug discovery; drug repurposing; drug resistance

(This special issue belongs to the Section General Virology)

Advances in Endemic and Emerging Viral Diseases in Livestock

edited by

Fernando Vicosa Bauermann

and

Mayara Maggioli

submission deadline 30 Apr 2025 | 9 articles | Viewed by 22828 | Submission Open

(This special issue belongs to the Section Animal Viruses)

Animal Virus Discovery and Genetic Diversity

edited by

Ryan Troyer

submission deadline 30 Apr 2025 | 10 articles | Viewed by 12821 | Submission Open

Keywords: animal virus; evolution; genetic; diversity; richness; emerging viruses; virome; metagenomics; ecology; cross-species transmission; zoonotic

(This special issue belongs to the Section Animal Viruses)

Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses

edited by Sasan Fereidouni

submission deadline 30 Apr 2025 | 5 articles | Viewed by 10532 | Submission Open

Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission

(This special issue belongs to the Section Animal Viruses)

Emerging Zoonotic Paramyxoviruses

edited by

Glenn Marsh

and

Jennifer Barr

submission deadline 30 Apr 2025 | 4 articles | Viewed by 8991 | Submission Open

Keywords: paramyxovirus; zoonotic; bat

(This special issue belongs to the Section Animal Viruses)

Viral Infections and Immune Dysregulation 2024–2025

edited by

Ester Ballana Guix

and

Ifeanyi Jude Ezeonwumelu

submission deadline 30 Apr 2025 | 3 articles | Viewed by 8297 | Submission Open

Keywords: immune responses; immune dysregulation; autoimmunity; viral infections; immunomodulation

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

PANoptosis in Viral Infection

edited by

Thirumala-Devi Kanneganti

submission deadline 30 Apr 2025 | 4 articles | Viewed by 8238 | Submission Open

Keywords: • Viruses• Inflammation• PANoptosis• PANoptosome

(This special issue belongs to the Section General Virology)

Congenital Cytomegalovirus Infection: Volume II

edited by

Giovanni Nigro

submission deadline 30 Apr 2025 | 4 articles | Viewed by 7668 | Submission Open

Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular and Cellular Biology of Human Oncogenic Viruses

edited by

Roberta Gonnella

submission deadline 30 Apr 2025 | 5 articles | Viewed by 7457 | Submission Open

Keywords: oncoviruses; antiviral drugs; viral oncogenesis; viral infection; oncogenic pathways; epigenetics

(This special issue belongs to the Section Human Virology and Viral Diseases)

COVID-19 and Pneumonia, 3rd Edition

edited by

Javier de Miguel-Díez

submission deadline 30 Apr 2025 | 6 articles | Viewed by 6691 | Submission Open

Keywords: COVID-19; pneumonia; lung diseases; diagnosis; treatment; prognosis

(This special issue belongs to the Section Coronaviruses)

Iridoviruses, 2nd Edition

edited by

Jian Zhang

and

Thomas B. Waltzek

submission deadline 30 Apr 2025 | 5 articles | Viewed by 6625 | Submission Open

Keywords: iridovirus; viral immune evasion; anti-viral immune responses; viral vaccine; viral pathogenesis; viral epidemiology

(This special issue belongs to the Section Animal Viruses)

Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options

edited by

Bluma G. Brenner

submission deadline 30 Apr 2025 | 5 articles | Viewed by 6155 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Phage Cocktails: Promising Approaches Against Infections

edited by Jin Woo Jun

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4602 | Submission Open

Keywords: phage cocktail; phage therapy; prophylaxis; infectious diseases; veterinary medicine; agriculture; food industry; zoonoses

(This special issue belongs to the Section Bacterial Viruses)

Hepatitis B Core-Related Antigen

edited by

Kuancheng Liu

submission deadline 30 Apr 2025 | 2 articles | Viewed by 4289 | Submission Open

Keywords: hepatitis B virus; core-related antigen; HBcrAg; HBc; HBeAg; PreC; biomarker; cccDNA activity; pathogenesis; disease progression

(This special issue belongs to the Section Human Virology and Viral Diseases)

Pseudorabies Virus, Third Edition

edited by

Yan-Dong Tang

and

Xiangdong Li

submission deadline 30 Apr 2025 | 3 articles | Viewed by 4216 | Submission Open

Keywords: pseudorabies virus; viral replication; virus– host interaction; pathogenesis and immunity; novel antiviral strategies

(This special issue belongs to the Section Animal Viruses)

Nanovaccines against Viral Infection

edited by

Linzhu Ren

, Jing Qian and

Fuxian Zhang

submission deadline 30 Apr 2025 | 3 articles | Viewed by 3271 | Submission Open

Keywords: nanoparticle; nanoantibody; nanovaccine; peptide-based nanovaccine; adjuvant and nanoadjuvant; antigen; nanotechnology in virus research

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Avian Reovirus

edited by

Sunil Mor

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2968 | Submission Open

Keywords: avian reovirus; pathogenesis; reassortment; virus evolution; vaccines

(This special issue belongs to the Section Animal Viruses)

Intra-patient Viral Evolution

edited by Adam A. Capoferri and

Mary Kearney

submission deadline 30 Apr 2025 | 1 articles | Viewed by 2909 | Submission Open

Keywords: intra-patient viral evolution; drug resistance; immune escape; co-evolution; virus persistence; virus evolution

(This special issue belongs to the Section Human Virology and Viral Diseases)

EBV and Disease: New Perspectives in the Post COVID-19 Era

edited by

Xiaoming Lyu

and Dengke Li

submission deadline 30 Apr 2025 | 3 articles | Viewed by 1980 | Submission Open

Keywords: EBV; reactivation and immune dysregulation; EBV-associated malignancies; autoimmune diseases; diagnostic and therapeutic

(This special issue belongs to the Section Human Virology and Viral Diseases)

Hepatitis B Surface Antigen: A Pivotal Role in the Virus–Host Interactions

edited by Patrick Labonte and Matthieu Blanchet

submission deadline 30 Apr 2025 | 1 articles | Viewed by 1737 | Submission Open

Keywords: hepatitis B surface antigen; HBsAg; HBV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Structure-Based Antiviral Drugs and Vaccine Design

edited by

Shi-hua Xiang

and

Fengwei Bai

submission deadline 30 Apr 2025 | 2 articles | Viewed by 1323 | Submission Open

Keywords: antiviral; structure based; AI-powered; drug design; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Human Cytomegalovirus Therapeutic Strategies and Clinical Applications

edited by Ravit Arav-Boger

submission deadline 30 Apr 2025 | 1 articles | Viewed by 605 | Submission Open

Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Host Defense, Viruses and Cell Death Pathways

edited by

Pascale Krejbich-Trotot

submission deadline 30 Apr 2025 | 1 articles | Viewed by 436 | Submission Open

Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Oncogenes

edited by

Francesca Caccuri

Antonella Bugatti

and Alberto Zani

submission deadline 30 Apr 2025 | Viewed by 382 | Submission Open

Keywords: oncogenic viruses; viral oncogenesis; human oncoviruses; virus–host interactions; antiviral agents; anticancer strategies

(This special issue belongs to the Section General Virology)

Advancements in Immunotherapy for Human Papillomavirus

edited by Katharine A. Price

submission deadline 30 Apr 2025 | Viewed by 266 | Submission Open

Keywords: human papillomavirus; cancer screening; vaccination; treatment; head-and-neck cancer; oropharyngeal cancer

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Modeling the Unholy Trinity of Pandemics: Viral Infection, Immunity, and Virus Transmission 2025

edited by

Esteban A. Hernandez-Vargas

submission deadline 30 Apr 2025 | Viewed by 266 | Submission Open

Keywords: mathematical modeling; within-hosts dynamics; virus transmission; immune factors; pharmaceutical interventions (e.g.; vaccination; antiviral); viral infection

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Tackling Viral Resistance—Advances in Mechanisms, Detection, and Control

edited by

Nuno Taveira

and Claudia Palladino

submission deadline 30 Apr 2025 | Viewed by 173 | Submission Open

Keywords: viral resistance; antiviral therapies; drug resistance mechanisms; epidemiology; diagnostic advancements; clinical management

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Experimental Animal and Organoid-Based Lethal Virus Infection Models for Human, Companion Animals and Livestock

edited by

Tomomi Takano

submission deadline 30 Apr 2025 | Viewed by 148 | Submission Open

Keywords: organoid models; experimental animals; lethal virus infections; pathogenesis; vaccine development; therapeutic drugs; in vitro models; in vivo models; human viral infections; companion animal viral infections; livestock viral infections; viral infection models; ferret; hamster; transgenic mouse

(This special issue belongs to the Section General Virology)

15-Year Anniversary of Viruses

edited by

Eric O. Freed

and

Abdul A. Waheed

submission deadline 1 May 2025 | 3 articles | Viewed by 2814 | Submission Open

Keywords: diversity; innovation; and impact of modern virology research; virology across all domains; Viruses fifteenth year anniversary

(This special issue belongs to the Section General Virology)

Antiviral Immune Responses of Bat

edited by Gustavo F. Palacios and Mariano Sánchez Lockhart

submission deadline 10 May 2025 | 3 articles | Viewed by 3744 | Submission Open

Keywords: bats; antiviral immunity; viral spillover; emerging infectious diseases; molecular and cellular aspects of bat immune systems

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Recent Advances in Antiviral Natural Products 2025

edited by

Massimiliano Galdiero

Carla Zannella

Annalisa Chianese

and

Rosa Giugliano

submission deadline 15 May 2025 | 4 articles | Viewed by 12585 | Submission Open

Keywords: virus; antiviral; host-defense; natural product; drug delivery; infectious disease

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Structural Biology of Bacteriophages

edited by Junjie Zhang and Bo Hu

submission deadline 16 May 2025 | 2 articles | Viewed by 2943 | Submission Open

Keywords: phage assembly; phage host recognition; host defense against phages; phage genome delivery; phage lysis; genome packaging; host receptors

(This special issue belongs to the Section Bacterial Viruses)

Hantavirus 2024

edited by Heinz Feldmann,

David Safronetz

Bryce Warner

and Kyle Rosenke

submission deadline 16 May 2025 | 1 articles | Viewed by 933 | Submission Open

Keywords: hantavirus; hantavirus cardiopulmonary syndrome; hemorrhagic fever with renal syndrome; ecology; disease manifestations; medical intervention; vaccines; therapeutics and clinical aspects

(This special issue belongs to the Section Human Virology and Viral Diseases)

Research and Clinical Application of Adenovirus (AdV), 3rd Edition

edited by

Julia Davydova

submission deadline 25 May 2025 | 1 articles | Viewed by 1376 | Submission Open

Keywords: adenovirus; gene therapy; cancer; oncolytic; vaccine; delivery

(This special issue belongs to the Section Human Virology and Viral Diseases)

Influenza, SARS-CoV-2, RSV and Other Vaccines: Immunogenicity Parameters and Protection, 3rd Edition

edited by

Zoltan Vajo

submission deadline 30 May 2025 | 6 articles | Viewed by 11540 | Submission Open

Keywords: SARS-CoV-2; serology; cellular immune response; protection; vaccines; influenza; Respiratory Syncytial Virus (RSV)

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Emerging Microbes, Infections and Spillovers, 2nd Edition

edited by

Ravi Kant

Tarja Sironen

and

Maciej Grzybek

submission deadline 30 May 2025 | 1 articles | Viewed by 525 | Submission Open

Keywords: emerging infections; virus spillovers; microbes; cross-species transmission; virus evolution; viral disease; virus reservoirs; virus– host interaction; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Endogenous Retrovirus Proteins and Their Functions, 2nd Edition

edited by

Benoit Barbeau

submission deadline 30 May 2025 | Viewed by 354 | Submission Open

Keywords: endogenous retrovirus; ERV envelope protein; receptor; cell fusion; cancer; pre-eclampsia; obstetric disorder; diagnosis; evolutionary conservation; gene regulation

(This special issue belongs to the Section Human Virology and Viral Diseases)

Influenza B Virus: From Infection to Prevention

edited by Saira Hussain

submission deadline 30 May 2025 | Viewed by 160 | Submission Open

Keywords: influenza B viruses; epidemiology; evolution; pathogenesis; immunity; vaccine; antivirals

(This special issue belongs to the Section Animal Viruses)

Chronic Infection by Oncogenic Viruses

edited by

Christophe Nicot

submission deadline 31 May 2025 | 6 articles | Viewed by 15556 | Submission Open

Keywords: virus transmission; virus replication; virus pathogenesis; virus latency; virus– host interactions; antiviral immune responses; virus-induced cellular transformation; antiviral drugs and vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Microscopy Methods for Virus Research

edited by Krishanu Ray

submission deadline 31 May 2025 | 5 articles | Viewed by 14131 | Submission Open

Keywords: viruses; fluorescence imaging; single-molecule imaging; super-resolution imaging; intra-vital imaging; electron microscopy; Cryo-EM; Cryo-ET

(This special issue belongs to the Section General Virology)

Functional and Structural Features of Viral RNA Elements

edited by

Stefan Weger

submission deadline 31 May 2025 | 4 articles | Viewed by 9412 | Submission Open

Keywords: RNA viruses; IRES elements; cap-independent protein synthesis; translation initiation; conserved RNA motifs

(This special issue belongs to the Section General Virology)

Human T-Cell Leukemia Virus (HTLV) Infection and Treatment

edited by Cynthia A. Pise-Masison and Damian F.J. Purcell

submission deadline 31 May 2025 | 5 articles | Viewed by 7611 | Submission Open

Keywords: HTLV; HTLV-associated myelopathy/tropical spastic paraparesis; adult T-cell leukemia/lymphoma; inflammation; neurodegeneration; therapeutics; infectious dermatitis; cancer; antiviral drugs

(This special issue belongs to the Section Human Virology and Viral Diseases)

Avian Respiratory Viruses, 4th Edition

edited by

Faizal Careem

submission deadline 31 May 2025 | 3 articles | Viewed by 6029 | Submission Open

Keywords: avian influenza virus; newcastle disease virus; infectious bronchitis virus; infectious laryngotracheitis; virus evolution; pathogenesis; virus– host interaction; vaccine; innate immune response; adjuvant; avian; avian metapneumovirus (aMPV)

(This special issue belongs to the Section Animal Viruses)

Within-Host Viral Dynamics: A Window into Viral Evolution

edited by

Xiaofeng Fan

and

Mahmoud Reza Pourkarim

submission deadline 31 May 2025 | 2 articles | Viewed by 5778 | Submission Open

Keywords: virome; metagenomics; phylogenetics; viral evolution; quasispecies; infectious diseases

(This special issue belongs to the Section General Virology)

TMPRSS2 in Influenza Virus and Coronavirus Infections

edited by

Judy Wai Ping Yam

and Sze Keong Tey

submission deadline 31 May 2025 | 2 articles | Viewed by 4608 | Submission Open

Keywords: TMPRSS2; influenza virus; coronavirus; viral infection; treatment of viral diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

Measles, Mumps, and Rubella

edited by Alberto Severini

submission deadline 31 May 2025 | 2 articles | Viewed by 3536 | Submission Open

Keywords: measles; mumps; rubella; molecular epidemiology; next generation sequencing; analysis of outbreaks; vaccine preventable diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

Tick-Borne Viruses: Transmission and Surveillance, 2nd Edition

edited by

Anna Papa

submission deadline 31 May 2025 | 1 articles | Viewed by 2930 | Submission Open

Keywords: tick-borne viruses; transmissibility; vector competence; virulence; interactions; surveillance; discovery; replication; pathogenesis; vaccine development

(This special issue belongs to the Section Invertebrate Viruses)

Virus Recombination

edited by

Alexandre Hassanin

submission deadline 31 May 2025 | 1 articles | Viewed by 1841 | Submission Open

Keywords: RNA viruses; DNA viruses; inter-genomic recombination; recombination rates; virus diversity; host ranges; methods of detection; models of recombination

(This special issue belongs to the Section General Virology)

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