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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Conquering Antiviral Drug Resistance via Development of Novel Antivirals and New Testing Methods for Drug Resistance: From Bench to Bedside

edited by

Benjamin M. Liu

Jun Wang

and David Hillyard

submission deadline 15 Oct 2025 | Viewed by 469 | Submission Open

Keywords: antivirals; viral hepatitis; HIV; Mpox; influenza; enterovirus; chronic viral infections; acute viral infections; diagnosis; antiviral drug resistance; antiviral drug mutations; antiviral drug development; viral evolution; treatment

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral RNA and Its Interaction with the Host

edited by

Redmond Smyth

and Neva Caliskan

submission deadline 24 Oct 2025 | 3 articles | Viewed by 7074 | Submission Open

Keywords: virus life cycle; host-virus interactions; viral RNA; RNA structures; RNA binding proteins; translational control; RNA modifications; immune evasion; RNA localization

(This special issue belongs to the Section General Virology)

Pestivirus 2025

edited by

Benjamin J. Lamp

and Christiane M. Riedel

submission deadline 30 Oct 2025 | 3 articles | Viewed by 2562 | Submission Open

Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF

(This special issue belongs to the Section Animal Viruses)

Mosquito-Borne Encephalitis Viruses

edited by

John Mackenzie

Allison Imrie

and

Marietjie Venter

submission deadline 31 Oct 2025 | 15 articles | Viewed by 24987 | Submission Open

Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Innate and Adaptive Immune Responses to Arbovirus Infections

edited by Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes and

Rafael Freitas de Oliveira França

submission deadline 31 Oct 2025 | 3 articles | Viewed by 11590 | Submission Open

Keywords: arbovirus; innate immunity; adaptive immunity; immunotherapeutic; immunoprophylaxis; vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viruses Associated with Gastroenteritis

edited by

Celso Cunha

and

Claudia Istrate

submission deadline 31 Oct 2025 | 6 articles | Viewed by 7107 | Submission Open

Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

HIV Neurological Disorders: 2nd Edition

edited by

Frank Denaro

submission deadline 31 Oct 2025 | 3 articles | Viewed by 6382 | Submission Open

Keywords: neuroinflammation; chronic HIV inflammation; HIV reservoir; HIV proteins; HIV receptors; HIV models; drugs of abuse; AIDS dementia complex; HIV noninfectious comorbidities; HIV healthcare disparities; HIV neuropathology

(This special issue belongs to the Section Human Virology and Viral Diseases)

HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0

edited by

Sonia Moretti

submission deadline 31 Oct 2025 | 3 articles | Viewed by 6030 | Submission Open

Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities

(This special issue belongs to the Section Human Virology and Viral Diseases)

Biotechnological Applications of Phage and Phage-Derived Proteins 2025

edited by

Silvio Santos

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5510 | Submission Open

Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic

(This special issue belongs to the Section Bacterial Viruses)

Viral Hemorrhagic Disease

edited by Joseph W. Golden and Aura R. Garrison

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4314 | Submission Open

Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses

(This special issue belongs to the Section Animal Viruses)

Bunyaviruses 2025

edited by Natasha L. Tilston-Lunel, Kenneth A. Stapleford and Ryan F. Relich

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3757 | Submission Open

Keywords: bunyaviruses; viral evolution; reassortment; vector biology; pathogenesis; animal models; vaccines and therapeutics

(This special issue belongs to the Section General Virology)

Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition

edited by

Alberto Borghetti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2503 | Submission Open

Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure

(This special issue belongs to the Section Human Virology and Viral Diseases)

Economically Important Viruses in African Crops

edited by James Peter Legg, Stephen Winter,

Rudolph Rufini Shirima

and

Samar Sheat

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1897 | Submission Open

Keywords: economically important viruses; african crops; cassava; banana; potato; yams; beans; cowpeas; maize; cacao; tomatoes; peppers; rice yellow mottle virus; chili; okra

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Molecular Epidemiology of Re-Emerging Arboviruses: Genetics and Ecology Insights

edited by

Marta Giovanetti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1771 | Submission Open

Keywords: arboviruses; climate change; epidemic– pandemic preparedness; genomic surveillance

(This special issue belongs to the Section Animal Viruses)

Current ART, Virologic Failure and Implications for HIV Drug Resistance, 2nd Edition

edited by Susan M. Schader

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1507 | Submission Open

Keywords: antiretroviral therapy (ART); HIV; AIDS; drug resistance; low level viremia (LLV); very low level viremia (VLLV); virologic failure (VF); clinical failure; viral load (VL); viral suppression; long-acting injectables (LAI); pre-exposure prophylaxis (PrEP); first-line ART; second-line ART; target detected; target not detected (TND); viral blips; novel mechanisms of HIV drug resistance; acquired genotypic drug resistance; adherence; people living with HIV (PLWH); management of people living with HIV (PLWH); risk factors; genotype; phenotype; treatment efficacy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Multiscale Modeling and Forecasting of COVID-19 and Respiratory Virus Dynamics

edited by

Gerardo Chowell

and Sunmi Lee

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1471 | Submission Open

Keywords: COVID-19 modeling; respiratory virus dynamics modeling; epidemic forecasting; parameter identifiability; multiscale transmission dynamics

(This special issue belongs to the Section General Virology)

Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals

edited by

Jing Zhang

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1137 | Submission Open

Keywords: vaccines; antiviral drugs; domestic animals; virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Regulation of HIV-1 Transcription and Latency, 2nd Edition

edited by

Uri Mbonye

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1118 | Submission Open

Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging and Re-emerging Infections: Impact on Substances of Human Origin (SoHO)

edited by

Ilaria Pati

and

Simonetta Pupella

submission deadline 31 Oct 2025 | Viewed by 569 | Submission Open

Keywords: substances of human origin (SoHO); infectious diseases; emerging and re-emerging infections; transmission risk

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus Infections and Host Metabolism 2025

edited by

Kuan Rong Chan

Yaw Shin Ooi

and Liang Cui

submission deadline 31 Oct 2025 | Viewed by 507 | Submission Open

Keywords: host– virus interactions; host response to viruses; immunometabolism; viral pathogenesis; metabolic reprogramming; metabolome; metabolism; lipidomics

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

The Immunosocial Approach to Emerging and Re-Emerging Viral Infections

edited by

Yiu Wing (Jason) Kam

submission deadline 31 Oct 2025 | Viewed by 391 | Submission Open

Keywords: viral infections; immunosocial approach; public health

(This special issue belongs to the Section General Virology)

Influenza Viruses in Wildlife 2025

edited by

Rebecca Poulson

and Wendy Blay Puryear

submission deadline 31 Oct 2025 | Viewed by 347 | Submission Open

Keywords: avian influenza; wild birds; wildlife; influenza epidemiology; surveillance; HPAI

(This special issue belongs to the Section Animal Viruses)

Vesicular Stomatitis Virus (VSV) 2025

edited by Michael A. Whitt,

Chad Mire

, Luis L. Rodriguez and

Andrea Marzi

submission deadline 31 Oct 2025 | Viewed by 321 | Submission Open

Keywords: pathogenesis; innate immune evasion; virus– vector interactions; virus– host interactions; epidemiology; entry; assembly; replication; transcription; vaccine; oncolytic

(This special issue belongs to the Section Animal Viruses)

2nd Edition: How to Adjust the Action Steps for Achieving the Global Hepatitis Virus (HBV/HCV/HDV) Elimination Targets?

edited by Ferruccio Bonino

submission deadline 31 Oct 2025 | 1 articles | Viewed by 246 | Submission Open

Keywords: antivirals; chronic viral hepatitis infections; HBV; HBV; functional cure; HCV; HCV vaccine; HDV; HDV-RNA; anti-HD

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Neurocognitive Dynamics and Biomarkers in HIV

edited by Mattia Trunfio and Carmela Pinnetti

submission deadline 1 Nov 2025 | 2 articles | Viewed by 2090 | Submission Open

Keywords: HIV infection; neurodegeneration; biomarkers; neuroinflammation; cognitive performance; mood; central nervous system

(This special issue belongs to the Section Human Virology and Viral Diseases)

Opportunistic Viral Infections, 3rd Edition

edited by

Carlo Contini

submission deadline 7 Nov 2025 | Viewed by 149 | Submission Open

Keywords: epidemiology of opportunistic viral infections; immunocompromised individuals (HIV/AIDS; transplants; tumors; chemotherapeutics; biotechnological drugs; etc.); advances in diagnosis; management and treatment of opportunistic viral infections; JC virus; HPV; CMV; EBV and other herpesvirus; human T-cell leukemia virus type 1 (HTLV-1); hepatitis B virus (HBV) and hepatitis C virus (HCV); polyomavirus; new Coronavirus including SARS-CoV-2; emerging viruses (arbovirus other zoonotic virus)

(This special issue belongs to the Section General Virology)

Virus-Host Interactions: From Mechanisms to Therapeutics

edited by

Leike Zhang

and

Ke Xu

submission deadline 15 Nov 2025 | Viewed by 490 | Submission Open

Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral– host interplay

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Recent Advances on Arboviruses Pathogenesis and Evolution

edited by Mariana Sequetin Cunha

submission deadline 17 Nov 2025 | 3 articles | Viewed by 4804 | Submission Open

Keywords: virus outbreaks; phylogeny; virus evolution; pathology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging Concepts in SARS-CoV-2 Biology and Pathology, 3rd Edition

edited by

Daniele Focosi

submission deadline 28 Nov 2025 | 2 articles | Viewed by 2459 | Submission Open

Keywords: SARS-CoV-2; epidemiology; virology; therapeutics; zoonoses

(This special issue belongs to the Section Coronaviruses)

Advances in Plant Virus/Viroid Detection and Identification Methods, 2nd Edition

edited by Laura Tomassoli and

Antonio Tiberini

submission deadline 28 Nov 2025 | Viewed by 142 | Submission Open

Keywords: plant viruses and viroids diagnostics; high-throughput sequencing; bioinformatics; virus taxonomy; virus/viroid– plant– vector interactions; real-time PCR; digital droplet PCR; hyperspectral imaging; machine learning; artificial intelligence; biosensors

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Molecular Mechanisms and Clinical Manifestations of Persistent Viral Infections

edited by

Anna Rosa Garbuglia

and Simone La Frazia

submission deadline 30 Nov 2025 | 7 articles | Viewed by 28085 | Submission Open

Keywords: mammalian viruses; chronic infection; latent infection; pathogenetic mechanisms; molecular pathways; oncogenic processes; episomal genome; host-integrated genome; immunity; antiviral drugs; endogenous viral element

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses

edited by

Sasan Fereidouni

submission deadline 30 Nov 2025 | 9 articles | Viewed by 19956 | Submission Open

Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission

(This special issue belongs to the Section Animal Viruses)

Advances in Rabies Research 2024

edited by

Charles E. Rupprecht

and Juan A. Montaño-Hirose

submission deadline 30 Nov 2025 | 5 articles | Viewed by 16278 | Submission Open

Keywords: rabies; zoonosis; vaccine; evolution; structural biology; viral replication; virus– host interaction; pathogenesis and immunity; clinical virology

(This special issue belongs to the Section General Virology)

Avian Reovirus

edited by

Sunil Mor

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8480 | Submission Open

Keywords: avian reovirus; pathogenesis; reassortment; virus evolution; vaccines

(This special issue belongs to the Section Animal Viruses)

Research and Clinical Application of Adenovirus (AdV), 3rd Edition

edited by

Julia Davydova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3317 | Submission Open

Keywords: adenovirus; gene therapy; cancer; oncolytic; vaccine; delivery

(This special issue belongs to the Section Human Virology and Viral Diseases)

Evolutionary Challenges of RNA Viruses: Insights from SARS-CoV-2 Variants and Emerging Respiratory Diseases

edited by

Ahmed El-Shamy

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3163 | Submission Open

Keywords: RNA viruses; evolution; influenza; SARS-CoV2; COVID-19; respiratory diseases

(This special issue belongs to the Section General Virology)

Peste Des Petits Ruminants (PPR): Progress and Efforts Toward 2030 Eradication

edited by

Satya Parida

and

Felix Njeumi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2665 | Submission Open

Keywords: peste des petits ruminants virus (PPRV); PPR; PPR in sheep; goats; cattle; buffaloes; and wildlife; PPR vaccination strategy; diagnosis; surveillance; epidemiology; episystem; socioeconomics; transmission; pathogenesis; atypical hosts and wildlife hosts

(This special issue belongs to the Section Animal Viruses)

Infectious Disease Epidemiology and Transmission Dynamics: 3rd Edition

edited by

Zhanwei Du

Lin Wang

Zeynep Ertem

Jose Luis Herrera Diestra

and

Yuan Bai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1918 | Submission Open

Keywords: infectious disease epidemiology; mathematical modeling; computational epidemiology; pharmaceutical interventions (e.g.; mass testing; vaccination and antiviral); infection and fatality burden; serology; phylogenetics and phylodynamics

(This special issue belongs to the Section General Virology)

Advances in Small-Molecule Viral Inhibitors

edited by Chiara Bertagnin

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1600 | Submission Open

Keywords: small-molecule inhibitors; PROTACs; antiviral compounds; drug discovery; protein– protein interaction inhibitors; enzymatic inhibitors

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Human Cytomegalovirus Therapeutic Strategies and Clinical Applications

edited by Ravit Arav-Boger

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1600 | Submission Open

Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cellular Mechanisms Regulating HIV Replication, 2nd Edition

edited by

Sergei Nekhai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 666 | Submission Open

Keywords: HIV-1; HIV-1 replication; host factors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Enveloped and Non-Enveloped Virus Assembly

edited by

Schuyler van Engelenburg

submission deadline 30 Nov 2025 | Viewed by 265 | Submission Open

Keywords: virus assembly; viral host factors; virus methodology; virus egress; membrane remodeling; cellular imaging; virus budding and release; protein-protein interactions; genome packaging; viral capsid; assembly inhibitors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section General Virology)

Virology Research in South Africa—from a Great Legacy to an Optimistic Future

edited by

Burtram C. Fielding

and

Ziyaad Valley-Omar

submission deadline 1 Dec 2025 | 9 articles | Viewed by 29871 | Submission Open

Keywords: SARS-CoV-2; other respiratory viruses; vaccines; HIV; antiviral resistance; zoonotic viruses; hepatitis viruses; enteric viruses; novel viruses/virus discovery

(This special issue belongs to the Section General Virology)

Structure-Based Antiviral Drugs and Vaccine Design

edited by

Shi-hua Xiang

and

Fengwei Bai

submission deadline 15 Dec 2025 | 3 articles | Viewed by 3808 | Submission Open

Keywords: antiviral; structure based; AI-powered; drug design; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bioinformatics and Computational Approaches in Viral Genomics and Evolution 2025

edited by Camila Malta Romano, Mariana Severo Ramundo and Nilson Coimbra

submission deadline 16 Dec 2025 | 4 articles | Viewed by 4283 | Submission Open

Keywords: bioinformatics tools; genomic surveillance; viral evolution; computational genomics; host-pathogen interactions

(This special issue belongs to the Section General Virology)

Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition

edited by

Islam Hamim

Ken Komatsu

and

Hiromitsu Moriyama

submission deadline 20 Dec 2025 | 4 articles | Viewed by 6801 | Submission Open

Keywords: diagnosis; surveillance; molecular mechanism; viroid; subviral agents; mycoviruses; biological control; pesticide resistance; antiviral defense mechanism; population genetics; recombination; gene expressions; host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Swine Viruses: Immunology and Vaccinology

edited by

Yue Wang

and

Hongying Chen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1224 | Submission Open

Keywords: swine virology; swine immunology; vaccine development; vaccinology; viral pathogenesis; vaccine design; disease prevention; swine health

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virology in Italy 2025—9th National Congress of the Italian Society for Virology

edited by

Enzo Tramontano

Arnaldo Caruso

Massimiliano Galdiero

Luisa Rubino

and

Gabriele Vaccari

submission deadline 20 Dec 2025 | Viewed by 352 | Submission Open

Keywords: Italy; emerging viruses; viral subversion of host cell processes; viruses of microbes; antivirals; vaccines; emerging methods in virology; RNA in virus infection; plant viruses; antiviral innate immunity; animal viruses; mycoviruses

(This special issue belongs to the Section General Virology)

Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons

edited by Ya-Fang Chiu and Bill Sugden

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7916 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

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