Special Issues

Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Conquering Antiviral Drug Resistance via Development of Novel Antivirals and New Testing Methods for Drug Resistance: From Bench to Bedside
edited by , and David Hillyard
submission deadline 15 Oct 2025 | Viewed by 471 | Submission Open
Keywords: antivirals; viral hepatitis; HIV; Mpox; influenza; enterovirus; chronic viral infections; acute viral infections; diagnosis; antiviral drug resistance; antiviral drug mutations; antiviral drug development; viral evolution; treatment
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral RNA and Its Interaction with the Host
edited by and Neva Caliskan
submission deadline 24 Oct 2025 | 3 articles | Viewed by 7109 | Submission Open
Keywords: virus life cycle; host-virus interactions; viral RNA; RNA structures; RNA binding proteins; translational control; RNA modifications; immune evasion; RNA localization
(This special issue belongs to the Section General Virology)
Pestivirus 2025
edited by and Christiane M. Riedel
submission deadline 30 Oct 2025 | 3 articles | Viewed by 2573 | Submission Open
Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF
(This special issue belongs to the Section Animal Viruses)
Mosquito-Borne Encephalitis Viruses submission deadline 31 Oct 2025 | 15 articles | Viewed by 25093 | Submission Open
Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses
(This special issue belongs to the Section Human Virology and Viral Diseases)
Innate and Adaptive Immune Responses to Arbovirus Infections
edited by Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes and
submission deadline 31 Oct 2025 | 3 articles | Viewed by 11618 | Submission Open
Keywords: arbovirus; innate immunity; adaptive immunity; immunotherapeutic; immunoprophylaxis; vaccines
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viruses Associated with Gastroenteritis submission deadline 31 Oct 2025 | 6 articles | Viewed by 7134 | Submission Open
Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis
(This special issue belongs to the Section Human Virology and Viral Diseases)
HIV Neurological Disorders: 2nd Edition
edited by
submission deadline 31 Oct 2025 | 3 articles | Viewed by 6409 | Submission Open
Keywords: neuroinflammation; chronic HIV inflammation; HIV reservoir; HIV proteins; HIV receptors; HIV models; drugs of abuse; AIDS dementia complex; HIV noninfectious comorbidities; HIV healthcare disparities; HIV neuropathology
(This special issue belongs to the Section Human Virology and Viral Diseases)
HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0
edited by
submission deadline 31 Oct 2025 | 3 articles | Viewed by 6044 | Submission Open
Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities
(This special issue belongs to the Section Human Virology and Viral Diseases)
Biotechnological Applications of Phage and Phage-Derived Proteins 2025
edited by
submission deadline 31 Oct 2025 | 2 articles | Viewed by 5517 | Submission Open
Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic
(This special issue belongs to the Section Bacterial Viruses)
Viral Hemorrhagic Disease
edited by Joseph W. Golden and Aura R. Garrison
submission deadline 31 Oct 2025 | 3 articles | Viewed by 4328 | Submission Open
Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses
(This special issue belongs to the Section Animal Viruses)
Bunyaviruses 2025
edited by Natasha L. Tilston-Lunel, Kenneth A. Stapleford and Ryan F. Relich
submission deadline 31 Oct 2025 | 3 articles | Viewed by 3769 | Submission Open
Keywords: bunyaviruses; viral evolution; reassortment; vector biology; pathogenesis; animal models; vaccines and therapeutics
(This special issue belongs to the Section General Virology)
Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 2509 | Submission Open
Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure
(This special issue belongs to the Section Human Virology and Viral Diseases)
Economically Important Viruses in African Crops
edited by James Peter Legg, Stephen Winter, and
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1907 | Submission Open
Keywords: economically important viruses; african crops; cassava; banana; potato; yams; beans; cowpeas; maize; cacao; tomatoes; peppers; rice yellow mottle virus; chili; okra
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Molecular Epidemiology of Re-Emerging Arboviruses: Genetics and Ecology Insights
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1783 | Submission Open
Keywords: arboviruses; climate change; epidemic– pandemic preparedness; genomic surveillance
(This special issue belongs to the Section Animal Viruses)
Current ART, Virologic Failure and Implications for HIV Drug Resistance, 2nd Edition
edited by Susan M. Schader
submission deadline 31 Oct 2025 | 2 articles | Viewed by 1523 | Submission Open
Keywords: antiretroviral therapy (ART); HIV; AIDS; drug resistance; low level viremia (LLV); very low level viremia (VLLV); virologic failure (VF); clinical failure; viral load (VL); viral suppression; long-acting injectables (LAI); pre-exposure prophylaxis (PrEP); first-line ART; second-line ART; target detected; target not detected (TND); viral blips; novel mechanisms of HIV drug resistance; acquired genotypic drug resistance; adherence; people living with HIV (PLWH); management of people living with HIV (PLWH); risk factors; genotype; phenotype; treatment efficacy
(This special issue belongs to the Section Human Virology and Viral Diseases)
Multiscale Modeling and Forecasting of COVID-19 and Respiratory Virus Dynamics
edited by and Sunmi Lee
submission deadline 31 Oct 2025 | 2 articles | Viewed by 1474 | Submission Open
Keywords: COVID-19 modeling; respiratory virus dynamics modeling; epidemic forecasting; parameter identifiability; multiscale transmission dynamics
(This special issue belongs to the Section General Virology)
Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1142 | Submission Open
Keywords: vaccines; antiviral drugs; domestic animals; virus
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Regulation of HIV-1 Transcription and Latency, 2nd Edition
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1124 | Submission Open
Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir
(This special issue belongs to the Section Human Virology and Viral Diseases)
Emerging and Re-emerging Infections: Impact on Substances of Human Origin (SoHO) submission deadline 31 Oct 2025 | Viewed by 569 | Submission Open
Keywords: substances of human origin (SoHO); infectious diseases; emerging and re-emerging infections; transmission risk
(This special issue belongs to the Section Human Virology and Viral Diseases)
Virus Infections and Host Metabolism 2025
edited by , and Liang Cui
submission deadline 31 Oct 2025 | Viewed by 508 | Submission Open
Keywords: host– virus interactions; host response to viruses; immunometabolism; viral pathogenesis; metabolic reprogramming; metabolome; metabolism; lipidomics
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
The Immunosocial Approach to Emerging and Re-Emerging Viral Infections submission deadline 31 Oct 2025 | Viewed by 392 | Submission Open
Keywords: viral infections; immunosocial approach; public health
(This special issue belongs to the Section General Virology)
Influenza Viruses in Wildlife 2025
edited by and Wendy Blay Puryear
submission deadline 31 Oct 2025 | Viewed by 347 | Submission Open
Keywords: avian influenza; wild birds; wildlife; influenza epidemiology; surveillance; HPAI
(This special issue belongs to the Section Animal Viruses)
Vesicular Stomatitis Virus (VSV) 2025
edited by Michael A. Whitt, , Luis L. Rodriguez and
submission deadline 31 Oct 2025 | Viewed by 322 | Submission Open
Keywords: pathogenesis; innate immune evasion; virus– vector interactions; virus– host interactions; epidemiology; entry; assembly; replication; transcription; vaccine; oncolytic
(This special issue belongs to the Section Animal Viruses)
2nd Edition: How to Adjust the Action Steps for Achieving the Global Hepatitis Virus (HBV/HCV/HDV) Elimination Targets?
edited by Ferruccio Bonino
submission deadline 31 Oct 2025 | 1 articles | Viewed by 255 | Submission Open
Keywords: antivirals; chronic viral hepatitis infections; HBV; HBV; functional cure; HCV; HCV vaccine; HDV; HDV-RNA; anti-HD
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Neurocognitive Dynamics and Biomarkers in HIV
edited by Mattia Trunfio and Carmela Pinnetti
submission deadline 1 Nov 2025 | 2 articles | Viewed by 2093 | Submission Open
Keywords: HIV infection; neurodegeneration; biomarkers; neuroinflammation; cognitive performance; mood; central nervous system
(This special issue belongs to the Section Human Virology and Viral Diseases)
Opportunistic Viral Infections, 3rd Edition
edited by
submission deadline 7 Nov 2025 | Viewed by 149 | Submission Open
Keywords: epidemiology of opportunistic viral infections; immunocompromised individuals (HIV/AIDS; transplants; tumors; chemotherapeutics; biotechnological drugs; etc.); advances in diagnosis; management and treatment of opportunistic viral infections; JC virus; HPV; CMV; EBV and other herpesvirus; human T-cell leukemia virus type 1 (HTLV-1); hepatitis B virus (HBV) and hepatitis C virus (HCV); polyomavirus; new Coronavirus including SARS-CoV-2; emerging viruses (arbovirus other zoonotic virus)
(This special issue belongs to the Section General Virology)
Virus-Host Interactions: From Mechanisms to Therapeutics
edited by and
submission deadline 15 Nov 2025 | Viewed by 491 | Submission Open
Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral– host interplay
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Recent Advances on Arboviruses Pathogenesis and Evolution
edited by Mariana Sequetin Cunha
submission deadline 17 Nov 2025 | 3 articles | Viewed by 4815 | Submission Open
Keywords: virus outbreaks; phylogeny; virus evolution; pathology
(This special issue belongs to the Section Human Virology and Viral Diseases)
Emerging Concepts in SARS-CoV-2 Biology and Pathology, 3rd Edition
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 2470 | Submission Open
Keywords: SARS-CoV-2; epidemiology; virology; therapeutics; zoonoses
(This special issue belongs to the Section Coronaviruses)
Advances in Plant Virus/Viroid Detection and Identification Methods, 2nd Edition
edited by Laura Tomassoli and
submission deadline 28 Nov 2025 | Viewed by 143 | Submission Open
Keywords: plant viruses and viroids diagnostics; high-throughput sequencing; bioinformatics; virus taxonomy; virus/viroid– plant– vector interactions; real-time PCR; digital droplet PCR; hyperspectral imaging; machine learning; artificial intelligence; biosensors
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Molecular Mechanisms and Clinical Manifestations of Persistent Viral Infections
edited by and Simone La Frazia
submission deadline 30 Nov 2025 | 7 articles | Viewed by 28156 | Submission Open
Keywords: mammalian viruses; chronic infection; latent infection; pathogenetic mechanisms; molecular pathways; oncogenic processes; episomal genome; host-integrated genome; immunity; antiviral drugs; endogenous viral element
(This special issue belongs to the Section Human Virology and Viral Diseases)
Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses
edited by
submission deadline 30 Nov 2025 | 9 articles | Viewed by 19992 | Submission Open
Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission
(This special issue belongs to the Section Animal Viruses)
Advances in Rabies Research 2024
edited by and Juan A. Montaño-Hirose
submission deadline 30 Nov 2025 | 5 articles | Viewed by 16346 | Submission Open
Keywords: rabies; zoonosis; vaccine; evolution; structural biology; viral replication; virus– host interaction; pathogenesis and immunity; clinical virology
(This special issue belongs to the Section General Virology)
Avian Reovirus
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 8499 | Submission Open
Keywords: avian reovirus; pathogenesis; reassortment; virus evolution; vaccines
(This special issue belongs to the Section Animal Viruses)
Research and Clinical Application of Adenovirus (AdV), 3rd Edition
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3325 | Submission Open
Keywords: adenovirus; gene therapy; cancer; oncolytic; vaccine; delivery
(This special issue belongs to the Section Human Virology and Viral Diseases)
Evolutionary Challenges of RNA Viruses: Insights from SARS-CoV-2 Variants and Emerging Respiratory Diseases
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3197 | Submission Open
Keywords: RNA viruses; evolution; influenza; SARS-CoV2; COVID-19; respiratory diseases
(This special issue belongs to the Section General Virology)
Peste Des Petits Ruminants (PPR): Progress and Efforts Toward 2030 Eradication
edited by and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2679 | Submission Open
Keywords: peste des petits ruminants virus (PPRV); PPR; PPR in sheep; goats; cattle; buffaloes; and wildlife; PPR vaccination strategy; diagnosis; surveillance; epidemiology; episystem; socioeconomics; transmission; pathogenesis; atypical hosts and wildlife hosts
(This special issue belongs to the Section Animal Viruses)
Infectious Disease Epidemiology and Transmission Dynamics: 3rd Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 1920 | Submission Open
Keywords: infectious disease epidemiology; mathematical modeling; computational epidemiology; pharmaceutical interventions (e.g.; mass testing; vaccination and antiviral); infection and fatality burden; serology; phylogenetics and phylodynamics
(This special issue belongs to the Section General Virology)
Advances in Small-Molecule Viral Inhibitors
edited by Chiara Bertagnin
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1604 | Submission Open
Keywords: small-molecule inhibitors; PROTACs; antiviral compounds; drug discovery; protein– protein interaction inhibitors; enzymatic inhibitors
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Human Cytomegalovirus Therapeutic Strategies and Clinical Applications
edited by Ravit Arav-Boger
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1601 | Submission Open
Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy
(This special issue belongs to the Section Human Virology and Viral Diseases)
Cellular Mechanisms Regulating HIV Replication, 2nd Edition
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 669 | Submission Open
Keywords: HIV-1; HIV-1 replication; host factors
(This special issue belongs to the Section Human Virology and Viral Diseases)
Enveloped and Non-Enveloped Virus Assembly submission deadline 30 Nov 2025 | Viewed by 266 | Submission Open
Keywords: virus assembly; viral host factors; virus methodology; virus egress; membrane remodeling; cellular imaging; virus budding and release; protein-protein interactions; genome packaging; viral capsid; assembly inhibitors
(This special issue belongs to the Section Human Virology and Viral Diseases)
Functional Structures in RNA Viruses
edited by Riccardo Delli Ponti, , and Laura Broglia
submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open
Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions
(This special issue belongs to the Section General Virology)
Virology Research in South Africa—from a Great Legacy to an Optimistic Future submission deadline 1 Dec 2025 | 9 articles | Viewed by 29915 | Submission Open
Keywords: SARS-CoV-2; other respiratory viruses; vaccines; HIV; antiviral resistance; zoonotic viruses; hepatitis viruses; enteric viruses; novel viruses/virus discovery
(This special issue belongs to the Section General Virology)
Structure-Based Antiviral Drugs and Vaccine Design
edited by and
submission deadline 15 Dec 2025 | 3 articles | Viewed by 3823 | Submission Open
Keywords: antiviral; structure based; AI-powered; drug design; vaccine design
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Bioinformatics and Computational Approaches in Viral Genomics and Evolution 2025
edited by Camila Malta Romano, Mariana Severo Ramundo and Nilson Coimbra
submission deadline 16 Dec 2025 | 4 articles | Viewed by 4297 | Submission Open
Keywords: bioinformatics tools; genomic surveillance; viral evolution; computational genomics; host-pathogen interactions
(This special issue belongs to the Section General Virology)
Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition submission deadline 20 Dec 2025 | 4 articles | Viewed by 6811 | Submission Open
Keywords: diagnosis; surveillance; molecular mechanism; viroid; subviral agents; mycoviruses; biological control; pesticide resistance; antiviral defense mechanism; population genetics; recombination; gene expressions; host range
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Swine Viruses: Immunology and Vaccinology
edited by and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1229 | Submission Open
Keywords: swine virology; swine immunology; vaccine development; vaccinology; viral pathogenesis; vaccine design; disease prevention; swine health
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Virology in Italy 2025—9th National Congress of the Italian Society for Virology submission deadline 20 Dec 2025 | Viewed by 353 | Submission Open
Keywords: Italy; emerging viruses; viral subversion of host cell processes; viruses of microbes; antivirals; vaccines; emerging methods in virology; RNA in virus infection; plant viruses; antiviral innate immunity; animal viruses; mycoviruses
(This special issue belongs to the Section General Virology)
Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons
edited by Ya-Fang Chiu and Bill Sugden
submission deadline 30 Dec 2025 | 3 articles | Viewed by 7935 | Submission Open
(This special issue belongs to the Section Human Virology and Viral Diseases)
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