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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Virus-Host Interactions: From Mechanisms to Therapeutics

edited by

Leike Zhang

and

Ke Xu

submission deadline 15 Nov 2025 | Viewed by 570 | Submission Open

Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral– host interplay

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Recent Advances on Arboviruses Pathogenesis and Evolution

edited by Mariana Sequetin Cunha

submission deadline 17 Nov 2025 | 3 articles | Viewed by 5604 | Submission Open

Keywords: virus outbreaks; phylogeny; virus evolution; pathology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in Plant Virus/Viroid Detection and Identification Methods, 2nd Edition

edited by Laura Tomassoli and

Antonio Tiberini

submission deadline 28 Nov 2025 | Viewed by 204 | Submission Open

Keywords: plant viruses and viroids diagnostics; high-throughput sequencing; bioinformatics; virus taxonomy; virus/viroid– plant– vector interactions; real-time PCR; digital droplet PCR; hyperspectral imaging; machine learning; artificial intelligence; biosensors

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Molecular Mechanisms and Clinical Manifestations of Persistent Viral Infections

edited by

Anna Rosa Garbuglia

and Simone La Frazia

submission deadline 30 Nov 2025 | 7 articles | Viewed by 31212 | Submission Open

Keywords: mammalian viruses; chronic infection; latent infection; pathogenetic mechanisms; molecular pathways; oncogenic processes; episomal genome; host-integrated genome; immunity; antiviral drugs; endogenous viral element

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses

edited by

Sasan Fereidouni

submission deadline 30 Nov 2025 | 10 articles | Viewed by 22488 | Submission Open

Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission

(This special issue belongs to the Section Animal Viruses)

Advances in Rabies Research 2024

edited by

Charles E. Rupprecht

and Juan A. Montaño-Hirose

submission deadline 30 Nov 2025 | 5 articles | Viewed by 18655 | Submission Open

Keywords: rabies; zoonosis; vaccine; evolution; structural biology; viral replication; virus– host interaction; pathogenesis and immunity; clinical virology

(This special issue belongs to the Section General Virology)

Avian Reovirus

edited by

Sunil Mor

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9641 | Submission Open

Keywords: avian reovirus; pathogenesis; reassortment; virus evolution; vaccines

(This special issue belongs to the Section Animal Viruses)

Evolutionary Challenges of RNA Viruses: Insights from SARS-CoV-2 Variants and Emerging Respiratory Diseases

edited by

Ahmed El-Shamy

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5275 | Submission Open

Keywords: RNA viruses; evolution; influenza; SARS-CoV2; COVID-19; respiratory diseases

(This special issue belongs to the Section General Virology)

Research and Clinical Application of Adenovirus (AdV), 3rd Edition

edited by

Julia Davydova

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4315 | Submission Open

Keywords: adenovirus; gene therapy; cancer; oncolytic; vaccine; delivery

(This special issue belongs to the Section Human Virology and Viral Diseases)

Peste Des Petits Ruminants (PPR): Progress and Efforts Toward 2030 Eradication

edited by

Satya Parida

and

Felix Njeumi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3258 | Submission Open

Keywords: peste des petits ruminants virus (PPRV); PPR; PPR in sheep; goats; cattle; buffaloes; and wildlife; PPR vaccination strategy; diagnosis; surveillance; epidemiology; episystem; socioeconomics; transmission; pathogenesis; atypical hosts and wildlife hosts

(This special issue belongs to the Section Animal Viruses)

Human Cytomegalovirus Therapeutic Strategies and Clinical Applications

edited by Ravit Arav-Boger

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2820 | Submission Open

Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Infectious Disease Epidemiology and Transmission Dynamics: 3rd Edition

edited by

Zhanwei Du

Lin Wang

Zeynep Ertem

Jose Luis Herrera Diestra

and

Yuan Bai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2054 | Submission Open

Keywords: infectious disease epidemiology; mathematical modeling; computational epidemiology; pharmaceutical interventions (e.g.; mass testing; vaccination and antiviral); infection and fatality burden; serology; phylogenetics and phylodynamics

(This special issue belongs to the Section General Virology)

Advances in Small-Molecule Viral Inhibitors

edited by Chiara Bertagnin

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1908 | Submission Open

Keywords: small-molecule inhibitors; PROTACs; antiviral compounds; drug discovery; protein– protein interaction inhibitors; enzymatic inhibitors

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Cellular Mechanisms Regulating HIV Replication, 2nd Edition

edited by

Sergei Nekhai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 992 | Submission Open

Keywords: HIV-1; HIV-1 replication; host factors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Enveloped and Non-Enveloped Virus Assembly

edited by

Schuyler van Engelenburg

submission deadline 30 Nov 2025 | Viewed by 295 | Submission Open

Keywords: virus assembly; viral host factors; virus methodology; virus egress; membrane remodeling; cellular imaging; virus budding and release; protein-protein interactions; genome packaging; viral capsid; assembly inhibitors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section General Virology)

Virology Research in South Africa—from a Great Legacy to an Optimistic Future

edited by

Burtram C. Fielding

and

Ziyaad Valley-Omar

submission deadline 1 Dec 2025 | 9 articles | Viewed by 32497 | Submission Open

Keywords: SARS-CoV-2; other respiratory viruses; vaccines; HIV; antiviral resistance; zoonotic viruses; hepatitis viruses; enteric viruses; novel viruses/virus discovery

(This special issue belongs to the Section General Virology)

Structure-Based Antiviral Drugs and Vaccine Design

edited by

Shi-hua Xiang

and

Fengwei Bai

submission deadline 15 Dec 2025 | 3 articles | Viewed by 4408 | Submission Open

Keywords: antiviral; structure based; AI-powered; drug design; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bioinformatics and Computational Approaches in Viral Genomics and Evolution 2025

edited by Camila Malta Romano, Mariana Severo Ramundo and Nilson Coimbra

submission deadline 16 Dec 2025 | 4 articles | Viewed by 4960 | Submission Open

Keywords: bioinformatics tools; genomic surveillance; viral evolution; computational genomics; host-pathogen interactions

(This special issue belongs to the Section General Virology)

Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition

edited by

Islam Hamim

Ken Komatsu

and

Hiromitsu Moriyama

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7454 | Submission Open

Keywords: diagnosis; surveillance; molecular mechanism; viroid; subviral agents; mycoviruses; biological control; pesticide resistance; antiviral defense mechanism; population genetics; recombination; gene expressions; host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Swine Viruses: Immunology and Vaccinology

edited by

Yue Wang

and

Hongying Chen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1397 | Submission Open

Keywords: swine virology; swine immunology; vaccine development; vaccinology; viral pathogenesis; vaccine design; disease prevention; swine health

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virology in Italy 2025—9th National Congress of the Italian Society for Virology

edited by

Enzo Tramontano

Arnaldo Caruso

Massimiliano Galdiero

Luisa Rubino

and

Gabriele Vaccari

submission deadline 20 Dec 2025 | 1 articles | Viewed by 729 | Submission Open

Keywords: Italy; emerging viruses; viral subversion of host cell processes; viruses of microbes; antivirals; vaccines; emerging methods in virology; RNA in virus infection; plant viruses; antiviral innate immunity; animal viruses; mycoviruses

(This special issue belongs to the Section General Virology)

RSV Epidemiological Surveillance: 2nd Edition

edited by Emanuele Castagno and Irene Raffaldi

submission deadline 30 Dec 2025 | 5 articles | Viewed by 9045 | Submission Open

Keywords: respiratory syncytial virus (RSV); epidemiological surveillance; bronchiolitis; children; newborns; infants

(This special issue belongs to the Section Human Virology and Viral Diseases)

Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons

edited by Ya-Fang Chiu and Bill Sugden

submission deadline 30 Dec 2025 | 3 articles | Viewed by 8759 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

Immune Mechanisms Against Respiratory Viral Pathogens

edited by Telugu Akula Narasaraju and Sunil More

submission deadline 30 Dec 2025 | Viewed by 139 | Submission Open

Keywords: respiratory viral infections; innate and adaptive immunity; host– pathogen interactions; inflammatory response; therapeutic interventions

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV Reservoirs, Latency, and the Factors Responsible

edited by Yuyang Tang and

Mudit Tyagi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 25579 | Submission Open

Keywords: HIV; HIV latency; HIV persistence; HIV eradication; HIV cure; HIV vaccine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infections and Immune Dysregulation 2024–2025

edited by

Ester Ballana Guix

and

Ifeanyi Jude Ezeonwumelu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 21677 | Submission Open

Keywords: immune responses; immune dysregulation; autoimmunity; viral infections; immunomodulation

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Microscopy Methods for Virus Research

edited by Krishanu Ray

submission deadline 31 Dec 2025 | 7 articles | Viewed by 20077 | Submission Open

Keywords: viruses; fluorescence imaging; single-molecule imaging; super-resolution imaging; intra-vital imaging; electron microscopy; Cryo-EM; Cryo-ET

(This special issue belongs to the Section General Virology)

Controlling Zoonotic Viral Diseases from One Health Perspective 2025

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 31 Dec 2025 | 5 articles | Viewed by 18428 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

SARS-CoV-2, COVID-19 Pathologies, Long COVID, and Anti-COVID Vaccines

edited by

Jean-Marc Sabatier

submission deadline 31 Dec 2025 | 6 articles | Viewed by 17054 | Submission Open

Keywords: SARS-CoV-2; COVID-19; long COVID; anti-COVID vaccines; spikeopathy; renin– angiotensin system

(This special issue belongs to the Section Coronaviruses)

EBV and Disease: New Perspectives in the Post COVID-19 Era

edited by

Xiaoming Lyu

and Dengke Li

submission deadline 31 Dec 2025 | 7 articles | Viewed by 15892 | Submission Open

Keywords: EBV; reactivation and immune dysregulation; EBV-associated malignancies; autoimmune diseases; diagnostic and therapeutic

(This special issue belongs to the Section Human Virology and Viral Diseases)

Host Cell-Virus Interaction, 4th Edition

edited by

Parikshit Bagchi

and

Anupam Mukherjee

submission deadline 31 Dec 2025 | 8 articles | Viewed by 14567 | Submission Open

Keywords: virus; viral proteins; virus entry; viral replication and pathogenesis; virus assembly and egress; intracellular trafficking of virus; host cell; cellular signaling; interferon pathway; inflammasome; viral immune evasion; immune response; cell death; apoptosis; autophagy; host-virus interaction; anti-viral strategies; direct acting antivirals; broad-spectrum antiviral agents; RNAi; microRNAs; neutralizing antibodies; molecular mechanisms of antivirals; molecular mechanisms of drug-resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Preparation for the Next Potential Pandemic—Chikungunya, Dengue, Zika and Other Viruses

edited by

Zoltan Vajo

submission deadline 31 Dec 2025 | 7 articles | Viewed by 13696 | Submission Open

Keywords: chikungunya; dengue; zika; next pandemic; epidemiology; pharmaceutics; immunology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Natural, Semisynthetic, and Synthetic Antiviral Drugs Targeting HIV and SARS-CoV-2

edited by

Otávio Augusto Chaves

and

Carlos Serpa

submission deadline 31 Dec 2025 | 6 articles | Viewed by 11851 | Submission Open

Keywords: antiviral design and discovery; natural product screening; natural products as a scaffold for semisynthetic antivirals; repurposing drugs; high-throughput screening; antiviral resistance; biophysical characterization of the interaction between antivirals and targets; combination of light and photosensitizers in antiviral discovery; cell-based and in vivo assays; in silico calculations

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

H5N1 Influenza Viruses

edited by

Daniel R. Perez

submission deadline 31 Dec 2025 | 6 articles | Viewed by 11672 | Submission Open

Keywords: H5N1; avian influenza; genetic diversity; immune response; vaccines and antiviral therapies

(This special issue belongs to the Section Animal Viruses)

Molecular Biomarkers for Viral Infection

edited by

Paulina Niedźwiedzka-Rystwej

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9331 | Submission Open

Keywords: molecular biomarkers; viral infections

(This special issue belongs to the Section Animal Viruses)

Application of Genetically Engineered Plant Viruses

edited by

Tsung-Chi Chen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8388 | Submission Open

Keywords: plant virus; infectious clone; viral vector; virus-induced gene silencing (VIGS); virus-like particles (VLPs); cross-protection

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Interplay Between Influenza Virus and Host Factors

edited by

Matloob Husain

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6246 | Submission Open

Keywords: influenza virus; host factors; proviral host factors; antiviral host factors; host adaptation; virus entry; virus assembly; virus release; innate antiviral response; interferon-stimulated genes; post-translational protein modifications

(This special issue belongs to the Section Animal Viruses)

Lung Immunity to Viral Infections

edited by

Ana Paula Duarte De Souza

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5901 | Submission Open

Keywords: respiratory virus; lung immune response; vaccines to respiratory virus; microbiota and lung immune response; environmental factors and lung immune responses; virus– host interaction in the lung; immunotherapies to prevent or treat respiratory viral infection

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Porcine Viruses 2025

edited by

Guoxin Li

Lingxue Yu

and

Jin Cui

submission deadline 31 Dec 2025 | 8 articles | Viewed by 5626 | Submission Open

Keywords: epidemiology; pathogenesis; immune evasion; virus evolution; vaccine

(This special issue belongs to the Section Animal Viruses)

Advancing Hepatitis Elimination: HBV, HDV, and HCV

edited by

Federico García

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5144 | Submission Open

Keywords: hepatitis elimination; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging Microbes, Infections and Spillovers, 2nd Edition

edited by

Ravi Kant

Tarja Sironen

and

Maciej Grzybek

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5085 | Submission Open

Keywords: emerging infections; virus spillovers; microbes; cross-species transmission; virus evolution; viral disease; virus reservoirs; virus– host interaction; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Severe Fever with Thrombocytopenia Syndrome Virus 2025

edited by

Masayuki Saijo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4673 | Submission Open

Keywords: SFTS; SFTSV; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Virus–Insect Interactions, 2nd Edition

edited by Li-Long Pan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4513 | Submission Open

Keywords: plant virus-insect vector interactions; virus transmission; entomopathogenic virus-insect host interactions; insect-specific viruses; induction and suppression of immune responses

(This special issue belongs to the Section Invertebrate Viruses)

Viral Diseases of Sheep and Goats

edited by Ramsés Reina and Álex Gómez

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4128 | Submission Open

Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines

(This special issue belongs to the Section Animal Viruses)

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: 2nd Edition

edited by

Christopher U. T. Hellen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3486 | Submission Open

Keywords: virus– host interactions; IRES elements; RNA structure; translation initiation; translational control; innate immune response; RNA modification

(This special issue belongs to the Section General Virology)

Animal Virus Discovery and Genetic Diversity: 2nd Edition

edited by

Ryan Troyer

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3327 | Submission Open

Keywords: animal virus; evolution; genetic; diversity; richness; emerging viruses; virome; metagenomics; ecology; cross-species transmission; zoonotic

(This special issue belongs to the Section Animal Viruses)

Antiviral Development for Emerging and Re-Emerging Viruses

edited by

Ming-Hon Hou

and

Shih-Chao Lin

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3216 | Submission Open

Keywords: protein– protein interaction; viral– host interaction; viral replication; antiviral; human viruses; emerging infections

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Human Hepatitis Viruses and Their Animal Homologues

edited by

Bo Wang

and

Xinglou Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2812 | Submission Open

Keywords: hepatitis viruses; animal virome; genetic diversity; genomic organization; ecology and evolution; molecular biology; molecular epidemiology; zoonotic potential

(This special issue belongs to the Section General Virology)

Oncogenic Infections and Cancer: Clinical Insights and Emerging Therapeutics

edited by G. Hossein Ashrafi and Mustafa Ozdogan

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2555 | Submission Open

Keywords: oncogenesis; viral oncology; bacterial oncogenesis; human papillomavirus (HPV); Epstein– Barr virus (EBV); Kaposi’ s sarcoma-associated herpesvirus (KSHV); hepatitis B virus (HBV); hepatitis C virus (HCV); human T-lymphotropic virus (HTLV-1); Helicobacter pylori; infection-driven cancers; molecular mechanisms; tumor microenvironment; immunotherapy; viral persistence; antiviral therapies; CRISPR-based treatments; cancer prevention; vaccine development; immune checkpoint inhibitors; diagnostic biomarkers; personalized medicine; translational oncology; therapeutic resistance; emerging therapeutics

(This special issue belongs to the Section Human Virology and Viral Diseases)

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