Neuroimmunology of Viral Infections
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 29
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the neuroimmunology of virus infections. Articles will address the ways viruses signal via innate immune pathways in CNS cells to produce either immune protection or, alternatively, disease in the CNS. A primary factor that drives virus-induced clinical disease is selective tropism of a particular virus for function-specific CNS cell types. Interestingly, targeted destruction of CNS cells relates more to innate immune responses to infection than to direct viral cytopathic effects. Beneficial or pathogenic responses are determined by cell-specific interactions of a virus with different innate immune receptors that generate specific outcomes involving programmed cell death and secretion of inflammatory cytokines. A wide spectrum of both neurotropic and non-neurotropic viruses that induce these responses and cause various forms of human neurologic disease are investigated in this Special Issue. Understanding the regulation of the virus–CNS cell interactions responsible for neuropathological outcomes is key to developing future therapeutic interventions.
Prof. Dr. Paul Massa
Guest Editor
Manuscript Submission Information
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Keywords
- viral neuropathogenesis
- innate immunity
- neurotropic virus
- programmed cell death
- immune response
- neurologic disease
- immunopathogenesis
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