HIV-HCV Coinfection
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".
Deadline for manuscript submissions: closed (17 April 2021)
Special Issue Editor
Interests: HIV infection; antiretroviral therapy; immunoactivation; HCV infection; virus-related cancers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
More than 2 million HIV-positive people are infected with HCV: HIV–HCV coinfection is a multifaceted virological figure with peculiar clinical aspects.
First, an effective therapy is available for both diseases. HCV infection can definitely be cured in most but not all patients, and reinfection is possible while combination antiretroviral therapy can successfully maintain plasma HIV RNA suppression but requires lifelong treatment and, moreover, residual replication may be detected in a variable percentage of subjects despite treatment compliance.
Second, HCV is an oncogenic virus that is the primary risk factor for hepatocellular carcinoma and is also linked to extrahepatic malignancy as lymphoid cancers: while infection with HIV, in itself, is not oncogenic, it is associated with an increased risk of developing AIDS-defining cancers as well as non-AIDS-defining cancers.
With this Special Issue of Viruses, our aim is to examine numerous topics related to this main theme. For example, we wish to explore if ongoing HCV infection, liver disease severity at antiretroviral treatment start, and achievement of sustained virological response with direct-acting antiviral treatment have an influence on long-term antiretroviral therapy efficacy; to describe an updated epidemiology of hepatic and extrahepatic malignancies in patients successfully treated for HIV–HCV infections; and to report studies discussing if the therapeutical approaches and long-term prognosis for cancer patients with HIV–HCV coinfection differ with respect to patients with only HIV infection, only HCV infection, or neither.
Research articles, review articles, as well as short communications are welcome.
Dr. Monica Basso
Guest Editor
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Keywords
- antiretroviral therapy
- long-term plasma HIV RNA suppression
- direct-acting antivirals
- liver disease severity
- therapeutical approach in cancer patients with HIV–HCV coinfection
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