Next Article in Journal
In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes
Previous Article in Journal
Specific Multiomic Profiling in Aortic Stenosis in Bicuspid Aortic Valve Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 12
Issue 2
10.3390/biomedicines12020382
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Probiotics as Potential Therapeutic Agents: Safeguarding Skeletal Muscle against Alcohol-Induced Damage through the Gut–Liver–Muscle Axis

by
Martina Sausa
1,
Alberto Fucarino
1,
Letizia Paladino
2,3,
Francesco Paolo Zummo
2,
Antonio Fabbrizio
1,
Valentina Di Felice
2,
Francesca Rappa
2,
Rosario Barone
2,
Antonella Marino Gammazza
2 and
Filippo Macaluso
1,2,3,*
1
Department of Theoretical and Applied Sciences, eCampus University, 22060 Novedrate, Italy
2
Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy
3
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(2), 382; https://doi.org/10.3390/biomedicines12020382
Submission received: 18 December 2023 / Revised: 3 February 2024 / Accepted: 5 February 2024 / Published: 7 February 2024
(This article belongs to the Section Molecular and Translational Medicine)
Browse Figures
Review Reports Versions Notes

Abstract

Probiotics have shown the potential to counteract the loss of muscle mass, reduce physical fatigue, and mitigate inflammatory response following intense exercise, although the mechanisms by which they work are not very clear. The objective of this review is to describe the main harmful effects of alcohol on skeletal muscle and to provide important strategies based on the use of probiotics. The excessive consumption of alcohol is a worldwide problem and has been shown to be crucial in the progression of alcoholic liver disease (ALD), for which, to date, the only therapy available is lifestyle modification, including cessation of drinking. In ALD, alcohol contributes significantly to the loss of skeletal muscle, and also to changes in the intestinal microbiota, which are the basis for a series of problems related to the onset of sarcopenia. Some of the main effects of alcohol on the skeletal muscle are described in this review, with particular emphasis on the “gut-liver-muscle axis”, which seems to be the primary cause of a series of muscle dysfunctions related to the onset of ALD. The modulation of the intestinal microbiota through probiotics utilization has appeared to be crucial in mitigating the muscle damage induced by the high amounts of alcohol consumed.
Keywords: alcohol; skeletal muscle; probiotics; intestinal microbiota; axis gut–muscle; axis liver–muscle alcohol; skeletal muscle; probiotics; intestinal microbiota; axis gut–muscle; axis liver–muscle

Share and Cite

MDPI and ACS Style

Sausa, M.; Fucarino, A.; Paladino, L.; Zummo, F.P.; Fabbrizio, A.; Di Felice, V.; Rappa, F.; Barone, R.; Marino Gammazza, A.; Macaluso, F. Probiotics as Potential Therapeutic Agents: Safeguarding Skeletal Muscle against Alcohol-Induced Damage through the Gut–Liver–Muscle Axis. Biomedicines 2024, 12, 382. https://doi.org/10.3390/biomedicines12020382

AMA Style

Sausa M, Fucarino A, Paladino L, Zummo FP, Fabbrizio A, Di Felice V, Rappa F, Barone R, Marino Gammazza A, Macaluso F. Probiotics as Potential Therapeutic Agents: Safeguarding Skeletal Muscle against Alcohol-Induced Damage through the Gut–Liver–Muscle Axis. Biomedicines. 2024; 12(2):382. https://doi.org/10.3390/biomedicines12020382

Chicago/Turabian Style

Sausa, Martina, Alberto Fucarino, Letizia Paladino, Francesco Paolo Zummo, Antonio Fabbrizio, Valentina Di Felice, Francesca Rappa, Rosario Barone, Antonella Marino Gammazza, and Filippo Macaluso. 2024. "Probiotics as Potential Therapeutic Agents: Safeguarding Skeletal Muscle against Alcohol-Induced Damage through the Gut–Liver–Muscle Axis" Biomedicines 12, no. 2: 382. https://doi.org/10.3390/biomedicines12020382

APA Style

Sausa, M., Fucarino, A., Paladino, L., Zummo, F. P., Fabbrizio, A., Di Felice, V., Rappa, F., Barone, R., Marino Gammazza, A., & Macaluso, F. (2024). Probiotics as Potential Therapeutic Agents: Safeguarding Skeletal Muscle against Alcohol-Induced Damage through the Gut–Liver–Muscle Axis. Biomedicines, 12(2), 382. https://doi.org/10.3390/biomedicines12020382

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop