Acetylated Diacylglycerol 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol in Autoimmune Arthritis and Interstitial Lung Disease in SKG Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Induction of Arthritis and Interstitial Lung Disease in SKG Mice
2.2. Clinical Scoring of Peripheral Arthritis
2.3. Lung Histology
2.4. Analysis of the Serum Cytokines by a Luminex Multiplex Cytokine Assay
2.5. Immunofluorescent Staining
2.6. Statistical Analysis
3. Results
3.1. Effect of PLAG on Arthritis
3.2. Effect of PLAG on Lung Inflammation and Fibrosis
3.3. Changes of Serum Cytokines after PLAG Treatment
3.4. Citrullinated Histone 3 Expression (NETosis) in the Lung Tissue after PLAG Treatment
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Lim, D.-H.; Lee, E.-J.; Lee, H.-S.; Kim, D.H.; Lee, J.-H.; Jeong, M.R.; Hong, S.; Lee, C.-K.; Yoo, B.; Youn, J.; et al. Acetylated Diacylglycerol 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol in Autoimmune Arthritis and Interstitial Lung Disease in SKG Mice. Biomedicines 2021, 9, 1095. https://doi.org/10.3390/biomedicines9091095
Lim D-H, Lee E-J, Lee H-S, Kim DH, Lee J-H, Jeong MR, Hong S, Lee C-K, Yoo B, Youn J, et al. Acetylated Diacylglycerol 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol in Autoimmune Arthritis and Interstitial Lung Disease in SKG Mice. Biomedicines. 2021; 9(9):1095. https://doi.org/10.3390/biomedicines9091095
Chicago/Turabian StyleLim, Doo-Ho, Eun-Ju Lee, Hee-Seop Lee, Do Hoon Kim, Jae-Hyun Lee, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, and et al. 2021. "Acetylated Diacylglycerol 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol in Autoimmune Arthritis and Interstitial Lung Disease in SKG Mice" Biomedicines 9, no. 9: 1095. https://doi.org/10.3390/biomedicines9091095