Aptasensors Based on Non-Enzymatic Peroxidase Mimics: Current Progress and Challenges
Abstract
:1. Introduction
2. Functional Mimics of Horseradish Peroxidase
2.1. Complex of Hemin with DNA G-Quadruplex
2.2. Nanozymes
2.3. Combination of Different HRP Mimics
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
Type of Peroxidase Mimic | Analyte | Substrate | LOD | Selectivity | Ref. |
---|---|---|---|---|---|
hemin-DNAzyme complex | ochratoxin A | TMB | 2.5 nM | ochratoxin B warfarin | [19] |
hemin-DNAzyme complex | AMP lysozyme | ABTS | 50 μM for AMP 5 pM for lysozyme | [20] | |
hemin-DNAzyme complex | AMP lysozyme | ABTS | 4 μM for AMP 0.1 pM for lysozyme | [21] | |
hemin-DNAzyme complex | ATP | ABTS | 1 μM | TTP, CTP, GTP | [22] |
hemin-DNAzyme complex | ATP cocaine | ABTS | 5 μM for ATP 1 μM for cocaine | [23] | |
hemin-GQ aptamer | VEGF | luminol | 18 nM | [24] | |
hemin-GQ aptamer | 8-OHdG | ABTS | 0.14 nM | 8-OHdG analogs (dC, dA, dU, T, dG) and metal ions (Zn2+, Hg2+, Cu2+, Ca2+, Mn2+, Al3+, Na+) | [25] |
hemin-DNAzyme complex | methamphetamine | ABTS | 0.5 nM | 15 general illicit drugs and metabolites: ketamine, norketamine, morphine, methadone, cocaine, mephedrone, cathinone, methcathinone, 3-trifluoromethylphenylpiperazine, 1-(3-tri-fluoromethylphenyl) piperazine, 3,4-methylenedioxy pyrovalerone, MDA, MDMA, EDDP, and mCPP | [26] |
hemin-DNAzyme complex | СЕА | ABTS | 5.5 pM | BSA, lysozyme, insulin, prostate-specific antigen | [27] |
hemin-DNAzyme complex | СЕА | 1,1′-oxalyldiimidazole | 0.58 ng/mL | alpha-fetoprotein, prostate-specific antigen | [28] |
hemin-DNAzyme complex | VEGF | ABTS | 1.7 pM | [29] | |
hemin-DNAzyme complex | S. aureus | luminol | 5 CFU/mL | S. epidermidis, S. warneri, P. aeruginosa; E. coli; C. Perfringens, and inactivated S. aureus | [30] |
hemin-DNAzyme complex | ATP | ABTS | [32] | ||
hemin-DNAzyme complex | cocaine | ABTS | 1 μM | chlorpromazine, diphenhydramine, promazine, scopolamine, caffeine, levamisole, lidocaine, and sucrose. minimal cross-reactivity to caffeine, chlorpromazine, promazine, and levamisole | [33] |
hemin-DNAzyme complex | MUC-1 (exosomes) | ABTS | 3.94 × 105 particles/mL | exosomes generated by normal liver cell line L-02 | [34] |
hemin-DNAzyme complex | quinclorac | TMB | 7.1 ng/mL | other quinolines and commonly used pesticides | [35] |
hemin-DNAzyme complex | MUC1 | ABTS | 5 nM | BSA, thrombin, lysozyme, IgG | [36] |
hemin-DNAzyme complex | ATP | TMB | 2.4 nM | CTP, GTP and UTP | [31] |
hemin-DNAzyme complex | Hg2+ ions thrombin sulfadimethoxine cocaine 17β- estradiol | ABTS | 4 μM for thrombine 0.5 μM for sulfadimethoxine | [37] | |
hemin-DNAzyme complex | ochratoxin A | TMB | 10 nM | other mycotoxins: aflatoxin B1, zearalenone, and ochratoxin B | [38] |
nanozyme: PtNPs | thrombin | TMB | 0.4 μM | [39] | |
nanozyme: Ag/Pt nanoclusters | thrombin | TMB | 2.6 nM | HSA, lysozyme, IgG, bovine thrombin | [40] |
nanozyme: AuNPs | kanamycin | TMB | 1.49 nM | penicillin, ampicillin, and streptomycin | [41] |
nanozyme: AuNPs | acetamiprid | TMB | 1.8 ppm | agritone, imidacloprid, and endothal | [42] |
nanozyme: AuNPs | sulfadimethoxine | TMB | 10 ng/mL | kanamycin, chloramphenicol, oxytetracycline hydrochloride | [43] |
nanozyme: AuNPs | murine norovirus | TMB | 30 particles/mL | S. aureus, E. coli, E. coli bacteriophage MS2 | [44] |
nanozyme: AuNPs | P. aeruginosa | TMB | V. cholerae, L. monocytogens, S. aureus | [45] | |
nanozyme: AuNPs | zearalenone | TMB | 10 ng/mL | aflatoxin B1, ochratoxin B, and metal ions (Ca2+, Na+, Mg2+, Zn2+) | [46] |
nanozyme: AuNPs | streptomycin | ABTS | 86 nM | tetracycline, oxytetracycline, carbamazepine, penicillin, amoxicillin, and diclofenac | [47] |
nanozyme: AuNPs | CD30+ small extracellular vesicles | TMB | 102–109 vesicles/mL | [48] | |
nanozyme: AuNPs | malachite green | TMB | 1.8 nM | sulfaguanidine, sulfanilamide, oxytetracycline hydrochloride, chloramphenicol | [49] |
nanozyme: AuNPs | sIL-2Ra | oPD | 1 pM | BSA, IL-5Ra, IL-13Ra2, IL-17Ra, CD166 | [50] |
nanozyme: AuNPs | C-reactive protein | TMB | 0.07 pM | [51] | |
nanozyme: AuNPs | retinol-binding protein 4 | luminol | 50 fM | [52] | |
nanozyme: AgNPs (tyrosine-capped) | chlorpyrifos | TMB | 11.3 ppm | diazinon, dichlorvos, phorate, monocrotophos, methamidophos, azamethiphos, aldicarb, clothianidin, captan, thiamethoxam, mancozeb | [53] |
nanozyme: Fe3O4 | S. typhimurium | TMB | 7.5 × 105 CFU/mL | [54] | |
nanozyme: Au/Pd | C. jejuni | TMB | 10 cells | H. pylori, E. coli | [55] |
nanozyme: core-shell gold nanorods | glucose insulin | TMB | 7.5 μM for glucose 0.2 pM for insulin | [56] | |
nanozyme: Au nanoclusters conjugated to BSA | S. typhimurium | TMB | 1 CFU/mL | E. coli O157:H7, S. aureus, P. aeruginosa | [57] |
nanozyme: Fe-MOF | thrombin | TMB | 0.8 nM | BSA, lysozyme, IgG, amino acids | [58] |
nanozyme: Cu-MOF | C-reactive protein | TMB | 240 pg/mL | glucose, glutathione, ascorbic acid, iron, creatinine, albumin, calcium | [59] |
nanozyme: Cu-MOF | thrombin | TMB | 360 pM | glucose, glutathione, ascorbic acid, iron, creatinine, albumin, C-reactive protein, calcium | [60] |
nanozyme: MOF | chlorpyrifos | TMB | 4.4 ng/mL | atrazine, carbaryl, diazinon, malathion, bisphenol A, imidacloprid | [61] |
nanozyme: MOG + PtNPs | fumonisin B1 | TMB | 2.7 pg/mL | ochratoxin A, ochratoxin B, aflatoxin B1, aflatoxin B2, zearalenone | [62] |
nanozyme: MOF-on-MOF | chlorpyrifos | TMB luminol | 5.3 ng/mL | Na+, K+, Mg2+, Zn2+, Cl−, NO3−, SO42−, Ac−, glucose, urea, citric acid, glyphosate, trichlorfon | [63] |
nanozyme: g-C3N4 NSs | CD63+ exosomes | TMB | 13.52 × 105 particles/μL | exosomes generated by nontumorigenic cell line | [64] |
nanozyme: SWCNTs | CD63+ exosomes | TMB | 5.2 × 105 particles/μL | exosomes generated by nontumorigenic cell line | [65] |
nanozyme: ZnFe2O4/rGO | S. typhimurium | TMB | 11 CFU/mL | S. aureus, E. coli, L. monocytogenes, V. parahaemolyticus | [66] |
hybrid: DNA nanotube/magnetic beads/ hemin-DNAzyme | insulin | TMB | 0.39 µIU/mL | [71] | |
hybrid: hemin-DNAzyme/PtNPs | thrombin | TMB | 15 pM | hemoglobin, lysozyme, BSA | [69] |
hybrid: DNAzyme + MOF + PtNPs | chloramphenicol | TMB | 0.03 pM | kanamycin, streptomycin, oxytetracycline, gentamicin sulfate, chlortetracycline, Zn2+, Ca2+, Mg2+, casein, globulin, albumin | [70] |
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Davydova, A.S.; Vorobyeva, M.A. Aptasensors Based on Non-Enzymatic Peroxidase Mimics: Current Progress and Challenges. Biosensors 2024, 14, 1. https://doi.org/10.3390/bios14010001
Davydova AS, Vorobyeva MA. Aptasensors Based on Non-Enzymatic Peroxidase Mimics: Current Progress and Challenges. Biosensors. 2024; 14(1):1. https://doi.org/10.3390/bios14010001
Chicago/Turabian StyleDavydova, Anna S., and Mariya A. Vorobyeva. 2024. "Aptasensors Based on Non-Enzymatic Peroxidase Mimics: Current Progress and Challenges" Biosensors 14, no. 1: 1. https://doi.org/10.3390/bios14010001