Looking Towards 2030: Strengthening the Environmental Health in Childhood–Adolescent Cancer Survivor Programs
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Collection
2.2. Environmental and Community Health Program for Longitudinal Follow-Up of Childhood and Adolescent Cancer Survivors
2.3. Pediatric Environmental History of Child and Adolescent Cancer Survivors
2.4. Descriptive and Geospatial Study
2.5. Spatial and Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Name | When? | Description |
---|---|---|
Individual Carbon Footprint | At diagnosis |
|
Green Page | At the time of diagnosis |
|
Risk Assessment | 1–4 months after diagnosis |
|
Transition Report “green passport” | At the end of the treatment |
|
Long-Term Follow-Up Plan | During the CACS’ lifespan |
|
% Survival (Typical Error) | |||||||
---|---|---|---|---|---|---|---|
2 Years | 5 Years | 10 Years | p-Value * | ||||
Sex | |||||||
Male | 82.8 | (1.8) | 82.0 | (1.9) | 81.2 | (1.9) | 0.651 |
Female | 86.3 | (1.8) | 83.3 | (2.0) | 81.6 | (2.1) | |
Income | |||||||
<2000 | 87.6 | (1.6) | 86.5 | (1.6) | 85.3 | (1.8) | 0.581 |
2000–3500 | 86.7 | (2.8) | 85.0 | (3.0) | 83.9 | (3.1) | |
>3500 | 90.9 | (4.3) | - | - | - | - | |
Family history of cancer 1st degree | |||||||
Yes | 89.0 | (4.7) | - | - | - | - | 0.759 |
No | 87.3 | (1.3) | 85.9 | (1.4) | 84.7 | (1.5) | |
Family history of cancer 1st degree or 2nd degree (younger than 55 years old) | |||||||
Yes | 90.4 | (2.8) | 88.3 | (3.1) | 86.9 | (3.3) | 0.465 |
No | 86.8 | (1.5) | 85.4 | (1.5) | 84.4 | (1.6) | |
Likert scale of air pollution in address at the time of diagnosis | |||||||
Acceptable | 85.7 | (2.5) | 83.4 | (2.7) | 81.8 | (2.9) | <0.05 |
Moderate | 89.3 | (1.8) | 87.9 | (2.0) | - | - | |
Very bad | 77.0 | (5.0) | - | - | - | - | |
Exposure to pesticides inside the residence | |||||||
Yes | 86.9 | (1.7) | 85.7 | (1.8) | 84.4 | (1.9) | 0.57 |
No | 88.0 | (2.0) | 86.6 | (2.2) | - | - | |
Contact with nature | |||||||
Every day | 88.7 | (1.8) | 87.5 | (1.9) | 87.0 | (2.0) | 0.937 |
Once a week | 88.6 | (1.9) | 86.7 | (2.1) | 85.2 | (2.3) | |
Once a month | 87.9 | (5.1) | - | - | - | - | |
Only in vacations | - | - | - | - | - | - | |
Never | - | - | - | - | - | - | |
Physical activity frequency | |||||||
Never | 90.0 | (3.4) | 88.5 | (3.6) | - | - | 0.283 |
1–2 days/week | 90.1 | (1.8) | 88.9 | (1.9) | - | - | |
3–4 days/week | - | - | - | - | 91.7 | (2.7) | |
> 5 days/week | 96.3 | (2.6) | - | - | - | - | |
Maternal smoking during pregnancy | |||||||
Yes | 88.1 | (1.9) | - | - | 85.2 | (2.2) | 0.824 |
No | 86.8 | (1.8) | 85.7 | (1.9) | - | - | |
Paternal smoking during pregnancy | |||||||
Yes | 86.1 | (1.8) | 84.8 | (1.9) | 83.4 | (2.0) | 0.231 |
No | 89.0 | (1.9) | 88.2 | (1.9) | - | - | |
Maternal smoking at diagnosis | |||||||
Yes | 85.9 | (2.4) | 85.3 | (2.5) | 83.5 | (2.7) | 0.352 |
No | 88.9 | (1.5) | 87.5 | (1.7) | - | - | |
Paternal smoking at diagnosis | |||||||
Yes | 85.9 | (2.2) | 85.0 | (2.3) | 83.6 | (2.4) | 0.327 |
No | 88.5 | (1.7) | 87.1 | (1.8) | - | - |
Cases by Period | CR/ASRw | SIR (CI 95%) by Type and Period | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
98–03 | 04–09 | 10–15 | 16–20 | Total Periods | % | MACAPE MUR 98-20 | Spain 00–16 | S. Europe 01-10 a | 1998–2003 | 2004–2009 | 2010–2015 | 2016–2020 | ||
Leukemia | 43 | 64 | 72 | 62 | 241 | 29.2 | 43.8 | 46.4/47.5 | /51.1 | 0.81 (0.62–1.05) | 1.01 (0.81–1.24) | 1.04 (0.85–1.26) | 1.12 (0.90–1.39) | |
ALL | 33 | 51 | 56 | 47 | 187 | 34.0 | 36.4/37.4 | --- | 0.81 (0.59–1.08) | 1.04 (0.81–1.31) | 1.04 (0.82–1.30) | 1.10 (0.85–1.40) | ||
AML | 8 | 11 | 12 | 12 | 43 | 7.8 | 8.0/8.1 | --- | 0.84 (0.42–1.51) | 0.97 (0.55–1.61) | 0.98 (0.56–1.58) | 1.22 (0.70–1.97) | ||
Lymphomas | 21 | 12 | 33 | 19 | 85 | 10.3 | 15.4 | 20.2/19.7 | /21.6 | 1.08 (0.73–1.56) | 0.56 (0.32–0.91) | 1.38 (1.01–1.85) | 0.93 (0.61–1.37) | |
HL | 9 | 5 | 9 | 12 | 35 | 6.4 | 7.4/7.0 | --- | 1.12 (0.59–1.08) | 0.57 (0.81–1.31) | 0.92 (0.82–1.30) | 1.43 (0.85–1.40) | ||
NHL | 12 | 7 | 24 | 7 | 50 | 9.1 | 6.8/6.7 | --- | 1.06 (0.58–1.95) | 0.56 (0.22–1.20) | 1.70 (1.09–2.54) | 0.59 (0.82–2.31) | ||
CNST | 41 | 47 | 65 | 42 | 195 | 23.7 | 35.4 | 35.8/36.1 | /37.6 | 0.95 (0.72–1.23) | 0.92 (0.71–1.18) | 1.16 (0.94–1.43) | 0.93 (0.71–1.21) | |
SNST | 14 | 13 | 27 | 16 | 70 | 8.5 | 12.7 | 13.1/14.0 | /14.5 | 0.92 (0.56–1.44) | 0.68 (0.40–1.08) | 1.33 (0.94–1.84) | 1.04 (0.66–1.59) | |
Others | 44 | 60 | 72 | 57 | 233 | 28.3 | 42.3 | 41.4/ | --- | --- | --- | --- | --- | |
TOTAL | 163 | 196 | 269 | 196 | 824 | 100 | 149.6 | 157.0/159.4 | --- | 0.89 (0.78–1.01) | 0.91 (0.80–1.02) | 1.14 (1.03–1.26) | 1.03 (0.92–1.16) | |
CR | 131.3 | 157.9 | 216.7 | 157.9 | 149.6 |
Incidence Cohort | % Survival (Typical Error) | ||||
---|---|---|---|---|---|
1 Year | 3 Years | 5 Years | 10 Years | ||
All Cancer (n = 733) | 98–03 | 84.7 (2.8) | 79.1 (3.2) | 76.1 (3.3) | 76.1 (3.3) |
04–08 | 83.5 (2.9) | 80.4 (3.2) | 80.4 (3.2) | 79.1 (3.2) | |
09–13 | 86.2 (2.3) | 82.5 (2.6) | 82.0 (2.6) | 79.7 (2.8) | |
14–18 | 91.8 (2.0) | 87.6 (2.4) | 85.5 (2.6) | --- | |
98–18 | 86.8 (1.3) | 82.7 (1.4) | 81.3 (1.4) | 80.1 (1.5) | |
Leukemia (n = 207) | 98–03 | 83.7 (5.6) | 79.1 (6.2) | 76.7 (6.4) | 76.7 (6.4) |
04–08 | 92.2 (3.8) | 92.2 (3.8) | 92.2 (3.8) | 92.2 (3.8) | |
09–13 | 83.9 (4.7) | 80.6 (5.0) | 79.0 (5.2) | 75.8 (5.4) | |
14–18 | 94.1 (3.3) | 90.2 (4.2) | 90.2 (4.2) | --- | |
98–18 | 88.4 (2.2) | 85.5 (2.4) | 84.5 (2.5) | 83.3 (2.6) | |
CNST (n = 79) | 98–03 | 78.0 (6.5) | 73.2 (6.9) | 68.3 (7.3) | 68.3 (7.3) |
04–08 | 71.1 (7.4) | 71.1 (7.4) | 71.1 (7.4) | 68.4 (7.5) | |
09–13 | 79.6 (5.5) | 77.8 (5.7) | 77.8 (5.7) | 71.6 (6.9) | |
14–18 | 87.0 (5.0) | 78.2 (6.1) | 78.2 (6.1) | --- | |
98–18 | 78.0 (6.5) | 73.2 (6.9) | 68.3 (7.3) | 68.3 (7.3) | |
Lymphoma (n = 79) | 98–03 | 81.0 (8.6) | 81.0 (8.6) | 81.0 (8.6) | 81.0 (8.6) |
04–08 | 85.7 (13.2) | 85.7 (13.2) | 85.7 (13.2) | 85.7 (13.2) | |
09–13 | 91.3 (5.9) | 91.3 (5.9) | 91.3 (5.9) | 91.3 (5.9) | |
14–18 | 96.4 (3.5) | 92.7 (5.0) | 92.7 (5.0) | --- | |
98–18 | 89.9 (3.4) | 88.6 (3.6) | 88.6 (3.6) | 88.6 (3.6) |
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Cabrera-Rivera, L.T.; Sweetser, B.; Fuster-Soler, J.L.; Ramis, R.; López-Hernández, F.A.; Pérez-Martínez, A.; Ortega-García, J.A. Looking Towards 2030: Strengthening the Environmental Health in Childhood–Adolescent Cancer Survivor Programs. Int. J. Environ. Res. Public Health 2023, 20, 443. https://doi.org/10.3390/ijerph20010443
Cabrera-Rivera LT, Sweetser B, Fuster-Soler JL, Ramis R, López-Hernández FA, Pérez-Martínez A, Ortega-García JA. Looking Towards 2030: Strengthening the Environmental Health in Childhood–Adolescent Cancer Survivor Programs. International Journal of Environmental Research and Public Health. 2023; 20(1):443. https://doi.org/10.3390/ijerph20010443
Chicago/Turabian StyleCabrera-Rivera, Laura T., Brittney Sweetser, José L. Fuster-Soler, Rebeca Ramis, Fernando A. López-Hernández, Antonio Pérez-Martínez, and Juan A. Ortega-García. 2023. "Looking Towards 2030: Strengthening the Environmental Health in Childhood–Adolescent Cancer Survivor Programs" International Journal of Environmental Research and Public Health 20, no. 1: 443. https://doi.org/10.3390/ijerph20010443