Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction

Zhong, Jianfeng; He, Yuan; Chen, Wenjiang; Shui, Xiaorong; Chen, Can; Lei, Wei

doi:10.3390/ijms151120355

Open AccessArticle

Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction

by

Jianfeng Zhong

^1,†,

Yuan He

^2,†,

Wenjiang Chen

¹,

Xiaorong Shui

³,

Can Chen

^1,2,* and

Wei Lei

^1,2,*

¹

Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China

²

Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China

³

Laboratory of Vascular Surgery, Guangdong Medical College, Zhanjiang 524001, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2014, 15(11), 20355-20364; https://doi.org/10.3390/ijms151120355

Submission received: 14 June 2014 / Revised: 20 October 2014 / Accepted: 24 October 2014 / Published: 6 November 2014

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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Abstract

Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI.

Keywords: acute myocardial infarction; biomarkers; diagnosis; miRNA; miR-19a

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MDPI and ACS Style

Zhong, J.; He, Y.; Chen, W.; Shui, X.; Chen, C.; Lei, W. Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction. Int. J. Mol. Sci. 2014, 15, 20355-20364. https://doi.org/10.3390/ijms151120355

AMA Style

Zhong J, He Y, Chen W, Shui X, Chen C, Lei W. Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction. International Journal of Molecular Sciences. 2014; 15(11):20355-20364. https://doi.org/10.3390/ijms151120355

Chicago/Turabian Style

Zhong, Jianfeng, Yuan He, Wenjiang Chen, Xiaorong Shui, Can Chen, and Wei Lei. 2014. "Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction" International Journal of Molecular Sciences 15, no. 11: 20355-20364. https://doi.org/10.3390/ijms151120355

APA Style

Zhong, J., He, Y., Chen, W., Shui, X., Chen, C., & Lei, W. (2014). Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction. International Journal of Molecular Sciences, 15(11), 20355-20364. https://doi.org/10.3390/ijms151120355

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Circulating microRNA-19a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction

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