The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer
Abstract
:1. Introduction
2. Results and Discussion
2.1. IMP2 Is Overexpressed in Precursor Lesions, PDAC and Linked to Lower Rate of Survival
2.2. IMP2 Is Involved in Metastasis
2.3. IMP2 Protein Is Overexpressed in PDAC Tissue Compared to Healthy Tissue and Associated with Lower Rate of One-Year Survival
3. Materials and Methods
3.1. Analysis of Human Gene Omnibus (GEO) Datasets
3.2. Tissue Microarray and Immunohistochemistry
3.3. Statistical Analysis
Author Contributions
Funding
Conflicts of Interest
Abbreviations
IGF2 | Insulin-like growth factor 2 |
IGF2BP2/IMP2 | IGF2 mRNA binding protein IMP2 |
NSCLC | Non-small cell lung cancer |
PDAC | Pancreatic ductal adenocarcinoma |
CTC | Circulating tumor cells |
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Positive Correlation | Negative Correlation | ||
---|---|---|---|
Gene | Correlation Coefficient R2 | Gene | Correlation Coefficient R2 |
ERO1-alpha | 0.867 | DMDL | −0.833 |
CD318 | 0.830 | CAF | −0.814 |
ARVD12 | 0.825 | SEPP1 | −0.801 |
BEN | 0.818 | AAM-B | −0.796 |
BCL-XL/S | 0.793 | ADAMTSL3 | −0.779 |
IP3R3 | 0.787 | 8B | −0.774 |
BM600-125KD | 0.783 | KIAA0922 | −0.765 |
PLEK2 | 0.781 | SEB | −0.761 |
TM9SF4 | 0.776 | GGTA1 | −0.760 |
DYT17 | 0.774 | APO-J | −0.753 |
TMCC1 | 0.772 | ADCL2 | −0.752 |
DXS1179E | 0.770 | ||
HSNOV1 | 0.764 | ||
SDC4 | 0.762 | ||
TFGA | 0.761 | ||
SMURF1 | 0.761 | ||
FAD104 | 0.760 | ||
CT31 | 0.759 | ||
FGD6 | 0.758 | ||
FBXO45 | 0.750 |
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Dahlem, C.; Barghash, A.; Puchas, P.; Haybaeck, J.; Kessler, S.M. The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer. Int. J. Mol. Sci. 2019, 20, 3204. https://doi.org/10.3390/ijms20133204
Dahlem C, Barghash A, Puchas P, Haybaeck J, Kessler SM. The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer. International Journal of Molecular Sciences. 2019; 20(13):3204. https://doi.org/10.3390/ijms20133204
Chicago/Turabian StyleDahlem, Charlotte, Ahmad Barghash, Philip Puchas, Johannes Haybaeck, and Sonja M. Kessler. 2019. "The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer" International Journal of Molecular Sciences 20, no. 13: 3204. https://doi.org/10.3390/ijms20133204